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Biomedical subjects

V I Skvortsova

Publications and source records attributed to V I Skvortsova.

12 recordsLinked to original sources
PubMed1997

[The metabolic therapy of ischemic stroke: the use of nootropil].

54 patients were treated by notropil (pyracetam). The results of therapy were evaluated statistically according to a number of clinical scales and neurophysiologic indices (EEG and evoked potentials with mapping of bioelectric activity). The results were compared with the data about 56 patients of the control group which were treated by traditional method without application of notropil. Notropil was applied by two ways: small doses (4-12 g daily) during 5 days or high doses (10-12 g daily) during 30 days from the moment when the patient admitted to the hospital. Intravenous injections of the drug were used in all cases as well as its internal administration. It was showed either efficiency of the drug, especially in high doses, in early beginning of the treatment and its duration for at least 30 days or good tolerance of the drug. Authors supposed that application of pyracetam is not adequate in strokes with severe disorders of consciousness and cerebral edema.

Acute Disease↗
PubMed1996

[The level of autoantibodies to glutamate receptors in the blood serum of patients in the acute period of ischemic stroke].

The level of autoantibodies (aAB) to main structural component of glutamate NMDA-receptors--phencyclidin-binding protein--was measured in blood serum of 70 patients during first 3, 6, 9, 12, 24 hours, and 3, 5 days after ischemic stroke development. 200 healthy individuals formed the control group. The elevation of titers of aAB to glutamate receptors was observed in all patients with severe or moderate disease from the very first hours of stroke. It was especially pronounced by 9-12 hours after stroke. The highest increase of aAB titers was found in severe cases. The tendency to normalization of aAB titers was observed by the end of the first twenty four hours. The degree of aAB elevation had the prognostic importance. The most favourable course of stroke with good restoration of damaged functions was predicted when stable normalization of the aAB level was observed by the third day of the disease development. Patients in stupor-coma condition did not show the phenomenon of aAB level's elevation during the first days of stroke, that reflected, probably, the development of immuno-deficient state. The decrease of aAB level down to subnormal values was extremely unfavourable prognostic sign proceeding patient's death as a rule.

Acute Disease↗
PubMed1995

[A comprehensive clinico-neurophysiological study of the efficacy of the pharmaceutical preparation glycine in acute ischemic stroke].

In intensive care unit 226 patients underwent step-by-step clinical and neurophysiological investigation of glycin chemotherapy efficiency in the acute period of ischaemic stroke. Investigation included double-blind placebo controlled method, monitoring (by means of EEG, toposelective mapping of EEG, SSEP, transcutaneous cortical electric stimulation, ENMG) of changes of brain functional state after the first drug dose and course of treatment, analysis of dose-dependent action of the drug, posticchemic follow-up. It was found out, that usage of the drug glycin (daily dose 1-2 grams) in the combined intensive treatment of stroke provided for significant acceleration of regress of disorders of consciousness and other general and focal signs (in comparison with severity-matched control group), and more complete and stable restoration of function to the end of acute period of the disease.

Acute Disease↗
PubMed1995

[The basic factors affecting outcomes in strokes].

Outcomes in 1102 patients with 3 main types of stroke have been analysed to determine the significance of basic stroke outcome predictors. They are: type of the stroke, location of the focus, gravity of the patient's condition when the first aid is performed, spectrum of hospital facilities, diseases of the patient before and besides the stroke. A decrease of the mortality rate and optimal level of ADL score after stroke can be provided in cases when intensive care units-general hospitals are the first step of treatment.

Activities of Daily Living↗
PubMed1994

[The clinico-neurophysiological study of the effect of cerebrolysin on brain function in the acute and early recovery periods of hemispheric ischemic stroke].

Thirty patients with acute ischemic stroke and at early terms of postapoplectic recovery received cerebrolysin in daily doses 10, 20 and 30 ml for 5 days or 10 ml, i. v. for 10 days, respectively. The patients were examined for neurological status and cerebral function. In acute stroke the highest effect occurred in the affection of moderate severity. In severe stroke the drug stimulated recovery of impaired functions which tended to restore more quickly than in control subjects. In early convalescents cerebrolysin improved motor functions. Details of the results of the combined neurophysiological examination in the course of the treatment are discussed.

Acute Disease↗
PubMed1992

[Clinico-neurophysiological studies of the conductive affective and effective systems of the brain in the acute period of ischemic stroke].

As many as 43 patients aged 44 to 79 years with acute ischemic brain stroke of hemispheric (n = 30) and stem (n = 13) localization underwent clinical and neurophysiological examinations including noninvasive transcutaneous cortical pacing and investigation of short-latent somatosensory evoked brain potentials. This made it possible to exercise objective dynamic control over the motor and sensitive conductive brain systems. Certain common regularities were revealed in the functional reconstruction of motor (pyramid) and sensitive conductors in the acute period of brain stroke. Quantitative criteria for estimating the degree of the functional motor and sensitive defect were determined together with those for predicting its recovery.

Acute Disease↗
PubMed1988

[The genesis of early clinical forms of cerebral circulatory failure and the effectiveness of different courses of therapeutic measures].

The authors have examined 214 patients with early clinical forms of cerebral circulation insufficiency. It has been established that discirculatory encephalopathy (DE) may be formed in two ways. One way is angiogenic and it leads to DE through a stage of initial manifestations of cerebral circulation insufficiency (IMCCI), the other way is related to the neurovascular nature of the disease (vegetovascular dystonia) and may lead to DE, bypassing the stage of IMCCI. It is concluded that therapy with vasoactive drugs is the basic therapy for patients with an angiogenic origin of the disease whereas in patients with a neurovascular genesis of the disease the basic approach is the administration of metabolism-correcting drugs.

Adult↗
PubMed1986

[Electroneuromyographic characteristics of the initial manifestations of cerebral circulatory insufficiency].

A clinico-electroneuromyographic examination covered 50 patients with initial manifestations of cerebral circulation insufficiency. The results are compared with the electroneuromyographic characteristics of discirculatory encephalopathy (20 patients), transient disorders of the cerebral circulation (28 patients) and ischemic strokes (30 patients). The parameter of "the sum of maximum amplitudes of M-responses" in the musculi manus and musculi pedis upon stimulation of the median, ulnar, tibial and fibular nerves at both sides developed by the authors was found to be diagnostically effective. This parameter proved to be significantly decreased in all cases of initial manifestations of cerebral circulation insufficiency. With increasing severity of cerebral circulation insufficiency in ischemic stroke the parameter reduced to the minimal values in a step-wise manner.

Adolescent↗
PubMedDate not supplied

[Syndromology and differential treatment of secondary cochleovestibulitis in patients with early clinical forms of cerebral circulatory insufficiency].

Altogether 136 patients with cochleovestibulitis and early clinical forms of cerebral circulation insufficiency were examined. Two types of syndrome were identified that were associated with the pathogenetic development: vascular and metabolic. Different diagnostic criteria and therapeutic approaches as applied to each type of syndrome were developed.

Adult↗