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V I Smirnova

Publications and source records attributed to V I Smirnova.

57 records · Page 4Linked to original sources
PubMedDate not supplied

[Monitoring of the informative saturation of EEG: a new method for intraoperative assessment of antinociceptive defense of the organism].

EEG is the result of brain activity aimed at processing the external and internal information. Intraoperative pain (as a specific type of information) developing because of inadequate anesthesia increases the total amount of information on the EEG. A new original method is proposed for assessing the efficacy of analgesia, based on computer monitoring of information saturation of EEG in the on-line regimen during an operative intervention under combined total anesthesia. Physiological and clinical significance of the detected phenomena is discussed.

Adolescent↗
PubMedDate not supplied

[The immunogenicity and heterogeneity of Pseudomonas pseudomallei surface antigen 8].

Surface antigen 8, one of pathogenicity factors of P.pseudomallei and having an antiphagocytic action, contains glycoprotein with a mol. wt. of 200 kD and proteins with mol wt. of 25, 30 and 34 kD. According to its chemical structure, the carbohydrate part of antigen 8 is the homogeneous polymer of 6-d-D-mannoheptose, and its protein component is a collection of monomer proteins with mol. wt. of 12-120 kD. The consecutive fractionation of antigen 8 by gel and ion exchange chromatography has made it possible to isolate its individual fragments, differing by the collection of antigenic components, as well as by their antiphagocytic and protective activity. Experiments have shown that glycoprotein with a mol. wt. of 200 kD is an active immunosuppressive agent, while protein with a mol. wt. of 34 kD produces a pronounced immunogenic effect.

Animals↗