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Biomedical subjects

V I Sokolov

Publications and source records attributed to V I Sokolov.

At least 19 recordsLinked to original sources

Temperature dependences of relaxation time, adiabatic and isothermal elastic moduli in ZnSe:Ni and ZnSe:Cr crystals obtained in an ultrasonic experiment.

Theory of ultrasonic absorption and dispersion, based on the Zener equation, was used for constructing the equations, those made it possible to restore the temperature dependences of relaxation time, adiabatic and isothermal elastic moduli on the basis of experimental data on the temperature dependences of ultrasound absorption and phase velocity. This method was used for processing the experimental results obtained in single crystals of ZnSe:Ni and ZnSe:Cr.

Journal Article↗

[The histogenesis of interrenal primordium of the adrenal gland in pig (Sus domestica)].

Using light, electron microscopy and cytochemistry, the early (embryonic week 4-8) stages of adrenal gland (AG) development were studied in domestic pig. The interrelations between the cells of the fetal cortex (FC) and chromaffin cells (CC) were traced. At week 5, AG primordium is represented by FC, which consists of the epithelioid cells, with the ingrowing neural cords containing CC islets. Starting at the early embryonic period and up to fetal period, CC and interrenal cells of FC are closely interrelated with each other and sinusoidal capillaries. Both cellular types are at different stages of differentiation, including the functionally active elements. At weeks 7-8, FC cells undergo involution, while those ones, left at periphery, form definitive cortex. CC are located in the central part of the organ and form suprarenal tissue. Authors hypothesize, that CC, migrating into AG primordium, initially induce the development of interrenal primordium, and later cause the involution of FC. This, possibly, may be explained by the fact that further antenatal and postnatal development of the organism requires more corticosteroids than the amount produced by FC.

Adrenal Cortex↗

[Development of adrenal chromaffin tissue].

The purpose of the present investigation was to study the morphological peculiarities of chromaffinoblasts and to determine their interrelations with the surrounding cellular elements of the fetal cortex at the early stages (embryonic weeks 4-7) of their migration into the developing adrenal gland of a pig. At week 5 neuro-cellular cords, consisting of so-called "naked" axons, neuroblasts, lemmoblasts, undifferentiated cells, chromaffinoblast clusters and chromaffinocytes, grow into the fetal cortex from side of abdominal aorta. In fetal cortex parenchyma chromaffin elements form cords, lobes, "medullary globes", which are enveloped by a basal membrane, which is a derivative of satellitocytes. Chromaffinocytes are stained with Wood's stain, potassium bichromate and, judging by the presence of secretory granules in their cytoplasm, are capable to synthesize summary catecholamines and to release them into the blood at the early stages of development. "Medullary globes" are the centers of proliferation and differentiation of the chromaffin cells in the adrenal medulla. The problem of chromaffin tissue stem cells is discussed.

Adrenal Glands↗

Postural reactions of circulation and its regulation during simulated weightlessness.

The extention and intensification of space exploration the influence of weightlessness on human organism and the formation of a new level of adaptation. The studies of blood circulation is very important because of frequent occurrence of cardiovascular disorders in the middle age subjects. In connection with extension and intensification of space exploration the influence of weightlessness on human organism and the formation of a new level of adaptation mechanisms acquires a special significance. The data obtained in recently undertaken model experiments and also during space flights indicate that weightlessness in many ways affects various physiological systems of organism, and first of all cardiovascular system with the development of reflex, humeral and metabolic reactions. It also indicates, that the changes in functioning of cardiovascular system brings about the disruption of its regular responses, which is foremost expressed in decreased antigravitational response, which manifests itself in lowered orthostatic stability. It is worth mentioning, that the changes during previous investigations of haemodynamics were mainly carried out with the subjects under forty, therefore age related specific features of blood circulation system response are described in a few articles. The studies of the kind are especially important because of frequent occurrence of cardiovascular disorders such as heart and brain vessels atherosclerosis, hypertension in the middle age, which can to a great extent complicate and affect the "acute" period of adaptation to weightlessness and readaptation process.

Adaptation, Physiological↗