PubMed Health⌕ Search

Biomedical subjects

V I Stepanenko

Publications and source records attributed to V I Stepanenko.

At least 19 recordsLinked to original sources
PubMed1990

[New approaches to the combined therapy of gonorrheal infection and accelerated methods for predicting its efficacy].

The authors suggest a combined method for the treatment of new torpid and chronic gonorrheal urethritis, involving preliminary studies of the agent's cellular respiration activity, and offer the technique for predicting the efficacy of such treatment. If gonococcal cellular respiration activity is low, aerobic processes in these agents are stimulated with daily subcutaneous injections of plasmol (a biostimulant), starting from 1 ml and building up the dose by 1 ml daily, and local irrigations of the urethra with oxygen cocktails via specially designed irrigators (Authors' Certificate No. 827071 USSR); such stimulation is carried out for 4 days prior to specific therapy. This treatment modality is maintained by an Authors Certificate No. 1107867 USSR. To check up the efficacy of the antibiotic chosen for therapy, a rapid method has been developed, consisting in measurement of the patient's blood serum antibacterial activity carried out in special chambers for cell microcultivation.

Adjuvants, Immunologic↗
PubMed1990

[Experience in treating chronic urethritis in men by iontophoresis and inductothermy].

A method for therapy of chronic urethritis by exposure to ionized solutions of drugs has been developed (Authors' Certificate of the USSR No. 876138). Active electrode is placed in the flask with the drug, passive one on the external surface of the body as close to the focus of involvement as possible. Ionized solution of the drug (2.5-3.1) is introduced into the urethra via a double-lumen catheter, washes its walls and saturates the mucosa; the solution is aspirated from the urethra through the other lumen of the catheter, thus removing the inflammation products from the urethra. Current density has made up 0.01-0.03 mA/cm2, length of session 12-15 min, 6-8 sessions per course. A device for local therapy of chronic urethritis by a combination of ionophoresis and inductothermy has been suggested (Authors' Certificate of the USSR No. 1084031). This device permits a simultaneous administration of 2 drugs: one from the tube via urethral mucosa, the other from the cuvette outwardly. Current density has made up 0.01-0.03 mA/cm2, with the current of 200 mA in the inductor. Length of inductometry and ionophoresis session is 10-15 min.

Adult↗
PubMed1990

[The treatment of urethral strictures of inflammatory origin by low-frequency ultrasound].

Urethral strictures were treated by ultrasonic exposure by means of a Barvinok MT apparatus, developed by the KVANT Research and Production Amalgamation in Kiev, and special ultrasonic wave-guides. The developed method essentially reduced the time of treatment, was conducive to a complete recovery of the urethral urine-excretory function and of its anatomic and histologic structure; it ruled out the necessity of repeated examinations with a bougie, catheterization, or surgical intervention.

Adult↗
PubMed1988

[Chemotaxis of Yersinia pseudotuberculosis as a mechanism in its search for target tissues of the host organism].

Y. pseudotuberculosis cells grown at biologically low temperature have been shown capable of chemotaxis with respect to carbohydrates and amino acids. During cultivation at 36-37 degrees C Y. pseudotuberculosis cells retain this property for 10-15 hours and then lose it. The mechanism of chemotaxis makes it possible for Y. pseudotuberculosis to "find" human and animal tissues and can facilitate the realization of the pathogenicity potential of these bacteria. When administered orally to mice motile bacteria, i. e. those grown at 6-8 degrees C, have been more virulent for the animals than nonmotile ones cultivated at 36-37 degrees C.

Animals↗
PubMedDate not supplied

[Coxsackie B viral infection in the etiology and clinical pathogenesis of psoriasis].

The data submitted point to the importance of the enteroviral infection, in particular, Coxsackie' B vira in the pathogenesis of many non-infectious diseases. Our studies explore the possibility for the Coxsackie B virus involvement in the etiopathogenesis of psoriasis. 25 examined patients with psoriasis revealed in 100% of cases antibodies to the Coxsackie B virus in diagnostic titres, with a number of patients having displayed a progressive increase in the titres of the above antibodies, which fact suggest to us that there may be an association between psoriasis and Coxsackie' B vira. The major proportion of seropositive psoriatic patients (88%) have been found to have antibodies to association of two, three or four Coxsackie' B vira, which fact can be taken as further evidence for their etiopathogenic part in the development of dermatosis. Antibodies to Coxsackie B1 and B5 virus have been shown to occur more frequently among seropositive patients, this underlying their particular importance in the development of psoriasis.

Antibodies, Viral↗
PubMedDate not supplied

[Complex diagnosis of chronic prostatitis complicated by disorders in sexual and reproductive functions].

A comprehensive clinical-and-laboratory evaluation was carried out in 132 patients with chronic prostatitis, the major proportion of these presenting with concomitant urethritis. It has been ascertained that infectious agents (chlamidia, gonococci, myco- and ureaplasms, trichomonads) play an important part in the origination and development of chronic prostatitis. In the examined patients spermograms were studied, with normospermia having been recorded in 45 (34%) patients, grade I oligospermia in 41 (31%), grade II oligospermia in 29 (22%), grade III oligospermia in 13 (10%), azospermia in 4 (3%) patients. There was no relatedness of changes revealed in qualitative characteristics of the ejaculate to etiology of chronic prostatitis. A comparative study was done on those parameters characterizing local (cell-mediated, humoral) immunity of the reproductive tract in patients with chronic prostatitis of different etiological (infectious) origin. Disturbances in local immunologic vigor in varying etiology chronic prostatitis have been shown to be of unidirectional character with no statistically significant difference in place.

Adult↗
PubMedDate not supplied

[A method of obtaining material for the bacteriological diagnosis of urethral diseases].

An installation is developed for sampling the contents of urethra (A. c. USSR 980726). The installation promotes acceleration of the correct diagnosis under the torpid and chronic inflammatory processes in the urethra. The above installation permits obtaining data on distribution of the microbic flora at a different depth of mucosa of the anterior area of the male urethra. In this case the mixing of samples taken for investigation from different sites is impossible.

Chronic Disease↗
PubMedDate not supplied

[Predicting the effectiveness of antibiotic therapy in the treatment of gonorrhea].

A complex method is suggested to prognosticate the efficiency of treating gonorrheal urethritis in men with allowance for a preliminary determination of the cell respiration activity in agents. In the case of low indices of these processes, it is possible to stimulate aerobic processes in gonococci if applying for 4 days before the specific treatment daily subcutaneous injections of plasmol (a biostimulator) by the ascending scheme and local irrigation of the urethra by oxygen cocktails through irrigators of special design. The developed method has the author certificate (A. c. 1107867 USSR). Application of the method shortens significantly the terms of treatment, the number of the infection recurrences being considerably decreased. To accelerate the determination of the sensitivity to antibiotics the procedure of genococcus microcultivation in special chambers is applied which permits observing the growth and reproduction of microorganisms in the phase-contrast microscope.

Anti-Bacterial Agents↗