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V I Trubnikov

Publications and source records attributed to V I Trubnikov.

At least 37 records · Page 2Linked to original sources
PubMed1995

[Inheritability of personality traits measured by MMPI in families of schizophrenic patients].

The results of genetic and mathematical analysis of MMPI-measured personality traits performed on material obtained 37 families of schizophrenia-afflicted probands were outlined. The results obtained suggest that heritability of traits in schizophrenic families is higher than in the general population. The discriminant function significantly differentiating between schizophrenics' and healthy people's relatives and having high heritability was calculated.

Female↗
PubMed1995

[Clinico-genetic aspects of cutaneous melanoma. II. Interconnection and pathogenetic commonality with dysplastic nevus syndrome].

Evidence for the role of dysplastic nevi (DN) in the development of cutaneous malignant melanoma (CMM) is presented. Primary multiple foci of CMM were found considerably more frequently in individuals with DN. The frequency of primary multiple CMM was found to be 3.1% in males with DN and 0.9% in males without DN; in females, 6.8 and 0.6%, respectively. Genetic correlation analysis was performed to determine the genetic interrelation between DN and CMM. In general, the genetic correlation coefficient was 0.9; i.e., predisposition to DN and CMM is determined by common genes for 90%. The frequency and distribution of constitutive fragile sites in chromosomes of peripheral lymphocytes was studied by the method of principal components for discrete variables. The site 1p22 is responsible for variability of the traits CMM and DN for 98.5%. On the one hand, this suggests that one of the supposed genes for CMM can be located at 1p22; on the other hand, CMM and DN are likely to have a common genetic determination or to be very tightly linked. Estimates of risk for the development of CMM in patients' relatives are given with reference to the variants of CMM manifestation and presence of DN.

Chromosomes, Human, Pair 1↗
PubMed1994

[A genetic analysis of the computed tomographic traits in schizophrenia].

The authors analyze clinical and CT evidence obtained on schizophrenic families (42 probands, 70 parents and 23 siblings) versus 162 healthy volunteers. Heritability coefficients were estimated for CT-parameters. Positive and negative psychopathological symptoms and CT-parameters seem to be correlated. It was established that such CT parameters as width of the frontal horn of the left lateral ventricle in the area of nucleus caudatus, width of the central compartment of the left lateral ventricle, width of the frontal horn of the right lateral ventricle in the area of nucleus caudatus, width of the central compartment of the right lateral ventricle may be regarded as markers of predisposition to schizophrenia. The results support the hypothesis on the role of genetic predisposition in the development of neuropathological changes in schizophrenic patients. This may be utilized in medico-genetic consulting and for formulation of the disease prognostic criteria.

Adult↗
PubMed1993

[Genetic analysis of the resting EEG parameters of schizophrenics and their relatives].

The heritability of the resting EEG parameters was studied in 45 schizophrenic families. In offspring--parent pairs (N = 94) and sibs pairs (N = 27) high correlation of average power values of frequency bands between relatives was found (r > 0.5 for alpha and beta power; r 0.2 to 0.45 for delta and theta power in different electrode placement). Linear discriminate functions (LDF) to separate 1) a control group (N = 20) from healthy relatives (N = 46), 2) control group from relatives with borderline pathology (N = 36) and 3) healthy relatives from relatives with borderline pathology were obtained. True classification is possible in 79%, 81% and 76% cases, heritability coefficients of LDF are 47.7, 64.6 and 57.1% respectively.

Adolescent↗
PubMed1993

[Genotoxic effects of the complex interaction of industrial factors].

Results of genoepidemiological study of reproduction function of workers in plastic goods production are presented. Incidence of spontaneous abortions (SA) in workers' families was analyzed. Frequency of early and late SA in women working in hazard production and wives of men working in harmful production is discussed. Differences in SA incidence in hazardous risk groups and controls were discovered.

Abortion, Spontaneous↗
PubMed1992

[Clinical and genetic studies of Alzheimer-type dementia].

The families of 128 probands with Alzheimer's disease (AD) and senile dementia (SD) were studied. Genetical and mathematical analyses were employed to estimate the clinico-genealogical findings. The genetic factors were found to be likely to make some contribution to the origin of Alzheimer-type dementia (ATD). The proportion of afflicted relatives considerably exceeded that of the above dementia patients. Two genetic models (monogenic and multifactorial) were tested. The limit estimations of genetic similarity between AD and SD manifestations both in the monogenic and multifactorial models denied the fact that there is a common major gene responsible for liability to Alzheimer-type dementias. The common gene modifiers were assumed to exist in AD and SD. In addition to the differences found between the types of inheritance in patients with these disease, the following features are: an oligogenic type of inheritance in SD and a quasi-dominant one with incomplete manifestations of homo- and heterozygotes in AD. Studies into the clinical polymorphism of Alzheimer-type dementias in hereditary cases enabled the authors to establish the genetically determined signs and the environmentally induced signs. The predisposing features (premorbid characteristic traits and specific features of mnemic and intelligence) were identified, which allowed the development of Alzheimer-type dementias to be predicted in 80% of women from hereditarily aggravated families.

Aged↗
PubMed1990

[Comparative clinico-genetic studies of senile dementia and Alzheimer's disease].

The families of 128 probands with senile dementia (SD) and Alzheimer's disease (AD) were entered into the study. The correlation between the familial and sporadic cases of the disease was established. A geneticomathematic analysis was employed to estimate the clinicogenealogical findings. Two genetic models (monogenous and multifactorial) were tested. The contribution of the genetic factors to SD and AD liability was assessed. As a result of a comparative clinicogenetic study of SD and AD it was found that there is no doubt about the contribution made by the genetic factors to the origin of the Alzheimer type dementia (ATD). The rate of the afflicted relatives considerably exceeded the population rates of the investigated patterns of dementia. The limit estimations of the genetic similarity between the manifestations of AD and SD, both in the monogenous and multifactorial models, were obtained, which rejects the presence of the common major gene responsible for liability to these patterns of the ATD. It was assumed that AD and SD are characterized by the presence of the common genes modifiers. In addition, the difference was established between the types of inheritance in persons afflicted with these diseases: an oligogenic type of inheritance in SD, a quasidominant type with incomplete penetrance of homo- and heterozygotes in AD.

Adult↗
PubMed1990

[Analysis of genotoxic effects of individual factors on chemical industry workers].

The article provides data on the study of occupational and non-occupational factors relating to the prevalence of early spontaneous abortions in couples engaged in fertilizer production. A higher degree prevalence of early spontaneous abortions was detected in several groups affected by specific factors. As this degree of prevalence was found in the groups in which it was only the father that had been exposed to the specific hazardous factors, it was considered that the factors in question either hindered the mutagen tolerance or were capable of their own germ cell mutagen action. It was established that lowered mutagen tolerance related to early abortions was markedly higher in groups exposed to organic substances' compounds and industrial noise.

Abortion, Spontaneous↗
PubMed1990

[Clinical characteristics of familial and sporadic forms of Alzheimer's disease].

Twenty-one cases of familial hereditary Alzheimer's disease and 17 sporadic cases were under observation. The probands' clinical status was assessed during a number of years in accordance with the standard method (based on a unified map). The clinical parameters (dementia structure, intensity of neurologic disorders, and so forth) were correlated at the identical disease stages. The differences in the character of the initial disease manifestations and the tempo of its progression as well as definite differences in the dementia structure at the pronounced stage and in the final stage allowed a conclusion about the ++clinico-genetic heterogeneity of the hereditary and sporadic cases of Alzheimer's disease.

Adult↗
PubMed1990

[Role of genetic and environmental factors in the determination of body weight and skinfold thickness in children having different blood pressure (a familial study)].

Based on intrafamilial correlations, a component genetic analysis was used to evaluate the contribution made by genetic and environmental factors to variance in body weight and skin fold thickness in children who had various blood pressure. In children with initially elevated and normal blood pressures, the phenotypic variation in the body weight and adipopexia is largely determined by genetic factors, whereas in those with initially lower blood pressure, the phenotypic variation in the above parameters is greatly affected by environmental factors, mainly by those of occasional nature. The findings provide evidence for a differential approach to the primary prevention of hyper- and hypotension in children and adolescents.

Adolescent↗
PubMed1989

[Genetic classification of clinical forms of childhood schizophrenia].

In an analysis of 225 families of probands with different forms of the course of children's schizophrenia, a hypothesis on the degree of their genetical similarity (or dissimilarity) was tested. Malignant and slow progredient form of children schizophrenia showed major genetical similarity (correlation coefficient 1.0) with the recurrent schizophrenia occupying a separate position having no common genetical predisposition factors with nuclear forms of schizophrenia. Paroxysmal progredient schizophrenia displayed a distinct genetical relation to any other form (genetical correlation coefficient ranging in 0.5-0.7).

Adolescent↗
PubMed1989

[Role of genetic and environmental factors in determination of arterial blood pressure level].

Three groups of families with different initial levels of arterial pressure in proband children were examined. The relationship was established between the levels of arterial pressure in children and those in their relatives of the first degree of kinship. Based on intrafamilial correlations, the phenotypic dispersion of systolic and diastolic arterial pressure was analyzed. It has been shown that as compared to the genetic factors, the environmental factors play a greater role in arterial pressure variability.

Adolescent↗
PubMed1989

[Heritability of clinical forms of childhood schizophrenia].

Investigated and genetically analyzed were inheritance variants in 225 families of probands with different forms of development of child schizophrenia and 519 blood relatives as well as in 1714 relatives of the 2nd and 3rd grades. Child schizophrenia as seen from the viewpoint of the monogenic model of inheritance with total or partial penetrance of the "major" gene proved inconsistent with the characteristics of family history and population distributions in the disease. The multifactorial model appeared the most adequate to describe the susceptibility system. In the framework of this model the correlation between the susceptibility components specific for a clinical form could be derived from distinguishing between genotypic and environmental components. The data indicate that in malignant and slow progredient schizophrenia the probands were genotypically similar to a greater extent that they were in paroxysmal-progredient form, as revealed by the inheritance coefficient of the former group (28-35%) which was lower than that of the latter group (64%).

Adolescent↗
PubMed1988

[The genetics of breast cancer, population and familial research and segregation analysis].

The data on clinico-genealogy studies of 1046 probands with breast cancer and their relatives are presented. The nature of inheritance corresponded to the Mendelian model. As to other families, there is no strong evidence for the monogene model both with complete and incomplete penetrance of mutant homo- and heterozygotes. Penetrance of homozygotes was 7.9-30.5%, this being 2.0-7.3% for heterozygotes. The conclusion is drawn that it is necessary to consider the regularities of inheritance of breast cancer in the light of the multifactorial model.

Adult↗
PubMed1988

[The genetics of breast cancer. A genetic dispersion analysis and the genetic heterogeneity of breast cancer].

The multifactorial nature of breast cancer was established based on population and family study, the contribution of genetic factors being 52% (premenopausal--62 and postmenopausal--39%). Genetic heterogeneity of different coefficients of inheritance of breast cancer with the portion of common genes was shown to be 53%. The analysis of breast cancer interaction with other malignant neoplasms revealed that the development of other malignant neoplasms was the result of the influence of partially common genes. On the basis of data obtained in this study, the tables of repeated risk for the relatives have been worked out which may be used for medico-genetic consultations.

Breast Neoplasms↗