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Biomedical subjects

V I Volkov

Publications and source records attributed to V I Volkov.

At least 19 recordsLinked to original sources
PubMed2005

[Reconstructive-restoration surgeries for nonspeciphic ulcerative colitis and colonic Crohn's disease].

Results of surgical treatment of 88 patients were presented, to whom radical surgery for nonspeciphic ulcerative colitis and Krohn's disease was performed. In 92% of observations the first-stage operation consisted of subtotal colectomy procedure with formation of separate ileostoma and sygmostoma, which was modified in the clinic. The reconstructive-restoration operation was performed in 61 (69.4%) of patients in 12 months after the first operation. The necessity to estimate the degree of the excluded colon readiness for the reconstructive-restoration operation performance was established, the terms of its application as well as the method and character of the operation were substantiated. The postoperative complications rate was (45,5+/-5,3)%. The result of reconstructive-restoration operation was considered good in 12, fair--in 61, unfair--in 15 patients. All the patients are alive.

Adult↗
PubMed2004

[Experience of laparoscopic hernioplasty in the treatment of inguinal hernia].

For 2001-2003 yrs period laparoscopic prosthesis hernioplasty was performed in 127 patients. Oblique reducible inguinoscrotal hernia had constituted the main nosological form of the disease. Peculiarities of preoperative preparation, anesthesiological support, operative procedures, complications postoperative management and medicinal securing of patients, immediate and late follow-up results of their surgical treatment were lighted on. The advantages of laparoscopic prosthesis hernioplasty were proved, such as the recurrence frequency lowering, social-economic efficacy, associated with reduction of the patients stationary stay, their labour rehabilitation and the recurrence absence.

Adult↗
PubMed2003

Electrosurface properties of poly(ethylene terephtalate) track membranes.

The electrosurface properties of track membranes made from poly(ethylene terephtalate) were determined by streaming potential (SP) and electron spin resonance (ESR) methods. The membrane pore diameters were in range from 20 to 200 nm. The pore electrical charge surface density values calculated with data obtained with methods mentioned differed dramatically. This difference was explained with the gel layer located at pore surface. The pore possesses a high large surface amassing a large electrical charge arising as a result of carboxylic groups dissociation. This charge cannot be detected with SP method due to high hydraulic resistance of the gel layer. In contrast to SP method, ESR detects all active centres parental of electrical charge at gel surface.

Electron Spin Resonance Spectroscopy↗
PubMed2002

[Proinflammatory cytokines and soluble intercellular adhesion molecule-1 in ischemic heart disease].

Blood serum levels of tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta) and soluble intercellular adhesion molecule-1 (sICAM-1) were measured by ELISA in patients with stable and unstable angina. Levels of cytokines and sICAM-1 were elevated in patients with stable and were even higher in patients with unstable angina. Among patients with stable angina those with more severe symptoms had higher serum activity of TNF-alpha and IL-1beta. Increased expression of sICAM-1 was associated with augmented systemic secretion of cytokines. This association was more pronounced in patients with unstable angina. Patients with stable angina and hyperlipidemia compared with those with normal lipids had higher levels of sICAM-1. Levels of both cytokines were similar in patients with and without hyperlipidemia. However levels of total and low density lipoprotein cholesterol increased while level of high density lipoprotein cholesterol decreased with elevation of TNF-alpha from the lowest to the highest tertile.

Adult↗
PubMed2001

Electron spin resonance studies of free radicals in gamma-irradiated soybean paste.

Free radicals in gamma-irradiated soybean paste were investigated by electron spin resonance (ESR) spectroscopy to determine the effect of temperature (77-296 K) and moisture content (1-54%) of samples irradiated at high dose (1-40 kGy). The samples were kept in liquid nitrogen (77 K) during irradiation and subsequent ESR measurements. The spectra shown at 77 K consisted of the hydrogen atom lines at low and high field and complicated symmetric spectrum. By increasing the microwave power, the line shape of ESR spectra altered, which indicated the detection of different paramagnetic centers at different microwave powers. In saturation curves, it was possible to select four types of spectra components which were different in their relaxation times. By the different irradiation doses, the change in free radical concentration showed a curvilinearly increasing relationship with irradiation dose in wet samples, whereas a proportional relationship was observed with dried samples. This might indicate that the indirect process of free radical formation was involved with the existence of free water radicals in the wet samples.

Electron Spin Resonance Spectroscopy↗
PubMed2001

[Surgical treatment of combined trans-sphincter and extra-sphincter rectal fistula].

The results of surgical treatment of 600 patients with rectal fistula were analyzed. Intrasphincter fistula was observed in 204 patients (34%), transsphinctered fistula--in 72 patients (12%), extrasphincter fistula--in 324 patients (54%). In order to decrease the rate of recurrence of fistula, during performance of plastics of internal hole of the fistula the graft of all the wall of rectum (not only its mucosa) was mobilized up to the level of anal sphincter. Post-operative complications and recurrence of fistula occurred in 4% of patients.

Anal Canal↗
PubMed2000

[Activity of the prostanoids system in inflammatory diseases of the colon].

Content of prostaglandins (PG) E2 and E2 alpha, prostacycline (PC) and tromboxane B2 (TxB2) in plasma of patient's blood with inflammatory diseases of large intestine was studied. In patients with nonspecific ulcerative colitis and Crohn's disease content of PGE2 is increased by 72.1%, PC--is decreased by 57%, TxB2--is increased by 144.8%. Detected changes have pathogenetic significance, their severity correlated with severity of the disease course. Tendency to normalization of the prostanoid system state was noted after performance of complex treatment.

Humans↗
PubMed1999

[Features of surgical rehabilitation of patients with severe inflammatory diseases of the large intestine].

The results of treatment of 354 patients with inflammatory colonic diseases were summarized. Nonspecific ulcerative colitis was diagnosed in 236, Crohn's disease--in 118 of them. There were operated on 83 (23.4%) of patients, including according to absolute indications--16 and the relative indications--67. There were elaborated and introduced an original methods of the operative interventions performance and of the postoperative guidance period. Mortality was 3.9%. Reconstructive-restoring operations were done in 24 patients, good and fair result was achieved in 16 (66.7%) of them. The poor results causes were analysed, indications and contraindications were substantiated as well as the terms of the reconstructive-restoring operations performance.

Colectomy↗
PubMed1996

Prevalence of Lyme disease spirochetes in Ixodes persulcatus and wild rodents in far eastern Russia.

Borrelia spirochetes were isolated from the adult ixodid tick (Ixodes persulcatus) in three areas of far eastern Russia, namely, Khabarovsk, Vladivostok, and Yuzhno-Sakhalinsk. Borrelia infective rates of ticks in those areas were 24.5, 41.4, and 25.1%, respectively (total rate was 26.6%). Spirochetes were also isolated from the tissues of small mammals captured at Khabarovsk (infective rate was 20.8%). Samples were classified by rRNA gene restriction fragment length polymorphism (RFLP) analysis. The isolated spirochetes from ticks were classified mainly RFLP ribotype group IV (B. garinii), followed by groups II (B. garinii), III (B. afzelii), and V (B. garinii), showing that B. garinii is a dominant species among them. Both B. garinii and B. afzelii were also found in rodents, and multiple infections with those two species were observed in some rodents. B. burgdorferi sensu stricto (group I) was not isolated from either ticks or rodents.

Animals↗
PubMed1991

[The treatment of atherosclerosis and hypertension using extracorporeal therapy methods].

Extracorporeal techniques (hemosorption, plasmapheresis, thrombocytoplasmapheresis, quantum hemotherapy) were studied for their impact on the clinical course of a disease and some hemostatic parameters in 370 patients with cardiovascular diseases (coronary heart disease, hypertensive disease, lower extremity at atherosclerosis obliterans). They were found to be effective in managing patients with atherosclerosis and arterial hypertension who are refractory to the conventional drug therapy. When there was a positive clinical action of therapy, the patients with coronary heart disease were demonstrated to show better parameters of lipid metabolism, immunological status and blood aggregation control system. The hypotensive effect of plasmapheresis in patients with arterial hypertension was followed by a decrease in pressor hormone levels and peripheral vasodilatation.

Adult↗
PubMed1990

[The content of fibronectin, fibrinogen, its degradation products and myoglobin in patients with ischemic heart disease].

ELISA using the test systems and a complex of equipment manufactured by Flow Company was employed to study over time the content of fibronectin, fibrinogen, products of its degradation and myoglobin in 178 patients suffering from coronary heart disease (stable and progressive angina pectoris, acute myocardial infarction). The concentration of myoglobin, fibronectin, fibrinogen and products of its degradation was established to depend on the gravity of coronary heart disease and the tame elapsed since the disease onset. In patients with progressive disease, there was an increased consumption of fibronectin which may be due both to its expenditure during blood coagulation and fulfillment of angioprotective function because of exacerbation of systemic atherosclerosis.

Adult↗
PubMed1990

[The prostacyclin-thromboxane system and the functional properties of the thrombocytes in patients of different ages with ischemic heart disease].

A study is presented of the reactions of prostacyclin-thromboxane system and functions of thrombocytes to physical loads inducing myocardial ischemia in patients with ischemic heart disease of different age groups. Examined were 62 patients with stable stenocardia of the II and III functional classes. Age of the patients: from 44 to 60 years. It was found that the elderly showed deterioration of the prostacyclin-thromboxane imbalance and a reduction of the sensitivity of thrombocytes to prostacyclin. The should be considered in instituting prolonged drug treatment.

Adult↗
PubMed1989

[The effect of nitrates and miskleron on the prostacyclin-thromboxane ratio and on the functional activity of the thrombocytes in stenocardia patients].

Results of treatment of patients with stable stenocardia by means of nitrates indicate that the antianginal effect was parallelled by an increase of the sensitivity of thrombocytes to prostacyclin and level of the plasma metabolite prostacyclin. The hypolipidemic effect of miscleron therapy is accompanied in patients with ischemic heart disease by reduction of the aggregation properties of thrombocytes and level of the metabolite thromboxane A2 in the plasma. The rationality of combined treatment with miscleron and nitrates is substantiated from the position of aimed effect on important links of atherogenesis and ischemic heart disease, namely functional properties of thrombocytes, prostacyclin-thromboxane ratio and level of blood lipids.

Angina Pectoris↗
PubMed1989

[The effect of a controlled physical load on the level of cyclic adenosine monophosphate in plasma and thrombocytes].

The authors studied the functional activity of thrombocytes, levels of plasma and thrombocytic cyclic AMP (cAMP) in the dynamics of a veloergometric test in patients with IHD and neurocirculatory dystonia. The revealed signs of hyperactivation of thrombocytes and absence of compensatory response of cAMP in IHD patients against the background of thresholds loads allows to improve the quality of prediction of thrombotic complications and control of treatment efficacy with agents possessing antithrombocytic activity.

Adult↗
PubMed1989

[Tick-borne encephalitis in a northern zone of coniferous and broad-leaved forests of a focal region of the Amur River basin].

The geographical variability of the population of tick-borne encephalitis (TBE) virus in the northern part of the zone of combined coniferous and broad-leaved forests was established; this variability was manifested by higher virulence and homogeneity of TBE virus strains, as shown in experiments on white mice receiving the virus extraneurally, in comparison with the southern part of the zone and by higher virus carriership of the ticks Ixodes persulcatus. With the epizootic situation remaining tense and the danger of TBE virus infection still present, TBE morbidity and mortality rates decreased in the years of the construction of the Baikal-Amur Railroad, which was due to greater attention given to measures for the prophylaxis of TBE during this period.

Animals↗