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Biomedical subjects

V Ia Levina

Publications and source records attributed to V Ia Levina.

6 recordsLinked to original sources
PubMed1990

[Modifying effects of ascorbic acid on nitrosodimethylamine-induced carcinogenesis].

In chronic experiments, albino noninbred rats were fed 20.0, 2.0 or 0.2 mg/l nitrosodimethylamine and 1000 or 100 mg/l ascorbic acid (average daily dose 100 or 10 mg/kg body weight). The study established the modifying effect of ascorbic acid on nitrosodimethylamine -- induced carcinogenesis. A decrease in tumor incidence was observed, particularly, at high level of the carcinogen. High dose ascorbic acid did not affect tumor incidence in intact animals; however, time to detection of the first tumor and mean duration of tumor development proved longer.

Animals↗
PubMed1985

[Carcinogenic effect of N-nitrosodimethylamine after application to rat skin].

A pronounced carcinogenic action was detected after ten-fold application of nitrosodimethylamine in 3 doses (calculated doses equal 10.0; 5.0; 1.0 mg per rat). The tumour incidence in groups is equal to 93.3%, 20.0%, 6.6% and 3.3% (in control). No morphological changes were found in the place of application. Induced tumours localized in the liver, lungs and kidneys.

Administration, Topical↗