Biomedical subjects

V Ianev

Publications and source records attributed to V Ianev.

12 recordsLinked to original sources

PubMed1994

[The current principles of the conservative treatment of patients with benign prostatic hypertrophy].

The etiopathogenesis, risk factors, and natural history of benign prostate hyperplasia are issues still not well enough clarified. Hormonal factors, stroma/epithelial interactions and cell mechanisms are among the underlying causes implicated. So far, no sound criteria for the choice of a conservative therapeutic approach to the condition have been worked out. The diverse treatment alternatives include hyperthermia, balloon dilatation, and administration of 5-alpha-reductase and aromatic inhibitors, as well as some phyto-preparations. Comparative assessment of the various methods point to the superiority of Finasterid administration. The latter, given at 5 mg daily dose leads to a reduction of clinical symptomatology, and decrease in prostate adenoma volume. The advantages of the method consist in preservation of the patient's libido and erectile capabilities, attributable to the normal plasma testosterone levels during prolonged drug taking. Specification of the indications for Finasterid treatment contribute to reduce operative activity in stage I of the disease.

5-alpha Reductase Inhibitors↗

PubMed1991

[The surgical and spontaneous elimination of kidney calculi--the type, incidence and treatment].

Results are reported of chemical (derivatographic and polarization microscopic) analysis of 2630 calculi removed by operation and 8607 spontaneously eliminated calculi. It was found that 82.7 per cent of the calculi removed by operation and 19.4 per cent of those eliminated spontaneously were mixed--composed of two or more components. The most common "pure" concrements were composed from oxalates and uric acid. The difference in the chemical types of the renal calculi of the two compared groups (removed by operation and spontaneously) is shown and followed up. Of interest is the different incidence of the two calcium oxalate hydrates in the two compared groups of renal calculi. Vevelite was more common in calculi removed by operation, while vedeline was the more common form in spontaneously eliminated calculi. Precision of the chemical form of the calculosis is recommended, with a view to including the genesis of stone formation for effective prophylaxis, treatment and metaphylaxis of the disease.

Adult↗

PubMed1989

[The current concept of tumor markers in oncologic urology--cytoplasmic markers].

The cells of testicular tumors and other malignant processes synthesize specific proteins which may be demonstrated intracellularly and may be quantitated in the patient serum. Of major value as markers in testicular tumors are alpha-fetoprotein and human choriongonadotropin. Radioimmune methods allow detection of minimal amounts of these substances at a moment when there are on other criteria for the presence of malignant process in the organism. This helps to establish early diagnosis and detection of relapses, precise determination of the stage and monitoring of treatment. Methods have also been developed for intracellular localization of the tumor markers, which allow precise diagnosis at cell level and retrospective studies on fixed biopsy specimens. The immunohistochemical classification which has been established and the experience being gained allowed the approach to the treatment of testicular tumors to be based in a major extent to the tumor markers.

Biomarkers, Tumor↗

PubMed1989

[The current concept of tumor markers in oncological urology--cell surface markers].

Basic problem of the diagnosis and treatment of superficial noninvasive bladder cancer is the absence of criteria for its potential invasiveness. In recent years it became clear that cell differentiation in some cancer forms essentially depends on the presence or absence of some antigens on the cell surface. These may be demonstrated by means of appropriate methods and may thus serve as marker in determining the prognosis and the stage of the disease and for monitoring the therapy in patients with bladder carcinoma. Of major value for the clinical practice are the clinical practice are the T-antigen, the ABO(H) antigens and the tumor-assisted antigens. Demonstration of T-antigen is effectuated by means of a modified erythrocyte-binding test and of the ABO(H) antigens by the Davidsohn's test. Correlation of these antigens with the pathological and clinical stage in a series of studies has demonstrated their practical significance in choosing an optimal therapeutic plan. There also exists relationship between the blood group antigens and the degree of malignancy in urothelial tumors. This allows a more precise evaluation of the indications for organ-preserving operation in some cases.

ABO Blood-Group System↗

PubMed1989

[Modern principles of the treatment of testicular tumors].

The modern principles of treatment of patients with germinative tumors of the testis are discussed. Essential are precise morphologic diagnosis and exact determination of the stage of the disease. Preference is given to the so called surgical-pathological staging, because it furnishes major objective information. Of the noninvasive methods of examination major value have computer axial tomography, measurement of the serum alpha-fetoprotein, human choriongonadotropin and SB1 levels, lymphography and pulmonary tomography. The role of tumor markers as criteria for early diagnosis of relapses and objective assessment of the effect of treatment is emphasized. The place of chemotherapy depending on the histologic variant and the stage of the process is determined. The results of modern chemotherapeutic schemes, which have shown statistically greatest effectiveness are discussed. The place of supra- and infrahilar lymph dissection as method of diagnosis and treatment is arguable. Some records (randomized) for treatment of germinative tumors of the testis, which might serve as practical guidance are presented.

Antineoplastic Combined Chemotherapy Protocols↗

PubMed1989

[The conservative treatment of Peyronie's disease with orgotein].

Results are analyzed of treatment of patients with induratio penis plastica by local application of orgotein. Fifteen patients with clinically manifest disease were the subject of this study; 4-8 mg Orgotein bulk was applied once a week in a total course of 8 to 10 injections. Criteria for the effect of treatment were: regression of the plaque consistency and size; decrease in the erectile deformity; change or disappearance of pain. Seven patients (46.7 per cent) experienced considerable improvement. Absence of effect was observed in one third of the patients. Quickest to be affected was pain and the penetration possibility, while the erectile deformity regressed at a slower rate. No side reactions or intolerance to the preparation were observed. Essential for the occurrence of therapeutic effect was the use of appliance for injection under high pressure. It this treatment fails, surgical management should be considered.

Anti-Inflammatory Agents, Non-Steroidal↗

PubMed1989

[The surgical treatment of Peyronie's disease by Nesbit's technic].

In 1965 Nesbit described an operative technique for correction of congenital penis distortions. Twenty eight patients with induratio penis plastica and marked erectile deformity were operated and followed up at the Department of Urology. All had previously received conservative therapy without effect. Indication for surgical intervention was the inability to perform coitus. The original method was applied: an elliptical opening was excised in tunica albuginea, contralateral to the distortion. In other cases compensation was performed by plication of tunica albuginea without opening the cavernous space. The result was satisfactory in 75 per cent of the patients and failure in 25 per cent. The latter was attributed to loosening of the correcting sutures or great rigidity of the plaque. The encouraging functional results and the rather uneventful postoperative period allow the authors to recommend Nesbit's operation for treatment of some forms of Peyronie's disease, which are not affected by conservative treatment.

Adult↗

PubMed1989