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Biomedical subjects

V Ivanisević

Publications and source records attributed to V Ivanisević.

At least 19 recordsLinked to original sources
PubMed1991

Circadian variations of platelet aggregability and fibrinolytic activity in patients with ischemic stroke.

The purpose of this study was to determine circadian dynamics of platelet aggregability and fibrinolytic activity in patients with ischemic stroke. The study was carried out in 21 male patients, aged from 51 to 65 years in acute phase of severe hemispheric brain infarction diagnosed clinically and radiologically. The examinations showed that circadian variations of platelet aggregability and fibrinolytic activity were persistent, but the intervals and the degree of oscillation differed from those in healthy persons. The significance of these disorders for clinical purposes was discussed.

Aged↗
PubMedDate not supplied

[Risk factors in the development of bleeding peptic ulcer].

INTRODUCTION: Gastric or duodenal peptic ulcer is the most common cause of bleeding from upper parts of the alimentary tract. Although there is a great number of these patients in the clinical practice, there are some contradictory characteristics in regard to the age of patient, localization of ulcer, the diameter of ulcer and Helicobacter pylori infection as possible risk factors in development of bleeding peptic ulcer. The aim of this work is evaluation of risk factors in our patients. MATERIAL AND METHODS: During this research we examened two groups of patients: a) first group consisted of patients with acute gastric or duodenal bleeding peptic ulcer, b) the second group consisted of patients without peptic ulcer bleeding. In both groups of patients we examined the most common risk factors for development of bleeding. This research took place in the Clinic for Surgery "Dr Dragisa Misović" in the period from January to December 1997. RESULTS: In both groups we had male predominance. Patients with bleeding peptic ulcers are statistically older when compared with the non-bleeding group (52.2 +/- 7.3:65.3 +/- 8.1). In both groups the anterior wall of the duodenum is the most common localization. In the group of bleeding ulcers we had high frequency of patients with localization of ulcers in the back wall of the duodenal bulb (20%). In this group of patients there was a high percentage of penetrating ulcers (62.5%) with active arterial bleeding (Forrest I a). Ulcers on the front wall of duodenal bulb and in small bend of stomach, as most common (over 50%), gave small peptic ulcers (under l cm) with capillary bleeding (oozing-Forrest I b) without haemodynamic complications. The presence of Helicobacter pylori infection is statistically significantly higher in the group of patients with bleeding peptic ulcers. DISCUSSION: The age of patients and localization of ulcer are very important and well known risk factors for development of bleeding peptic ulcer. However, in the last ten years Helicobacter pylori infection has become one of the most important risk factors. All Helicobacter pylori positive patients were treated with three component eradicational therapy for Helicobacter pylori. In this way we restricted the number of recurrent bleeding. CONCLUSION: In our opinion the age of patient, localization of ulcer, diameter and Helicobacter pylori infection are very important risk factors for development of bleeding peptic ulcer.

Adult↗
PubMedDate not supplied

[Helicobacter pylori infection and a decrease in the pH of gastric juice as a possible cause of bleeding in erosive gastritis].

INTRODUCTION: Bleeding erosive gastritis and ulcer disease are the most common causes of bleeding from the upper parts of the alimentary tract. Over the period of the last 10 years there has been an increased number of patients where Helicobacter pylori is mentioned as the possible cause of infection. At the same time in this group of patients pH values were decreased. During our research we wanted to examine the influence of local pH value and Helicobacter pylori infection on the occurrence of bleeding erosive gastritis. MATERIAL AND METHODS: During this research we examined two groups of patients. The following parameters were examined within these two groups of patients: 1. presence of Helicobacter pylori infection; 2. histopathologic changes in mucus; 3. there were 57 patients with a bleeding form of gastritis of unknown etiology, whereas the second group consisted of 351 patients with non-bleeding form of gastritis. We examined the localization: 4. local pH. RESULTS: The presence of Helicobacter pylori infection is statistically significantly higher in the group of patients with bleeding gastritis, when compared to the non-bleeding group (72%:57%). Within the Helicobacter positive patients the most common change of mucose (over 90%) is active chronic gastritis. The presence of erosions and histopathological changes characteristic for Helicobacter pylori infection coincides with colonization of Helicobacter in the antrum. The pathogenetic action of bacteria in antrum decreases the local pH. Therefore the lowest value of local pH occurred in the group of bleeding Helicobacter pylori positive gastritis (1.72). DISCUSSION: Results of this research helped us in treatment of helicobacter pylori positive patients making a risk group for development of recurrent bleeding. We accomplished therapeutical effect in 80% of patients by using a three component eradication therapeutic protocol for helicobacter pylori. Within the group of patients who have been cured, regression of histopathological changes occurred and increase of local pH took place. In the group with persistent infection we have come across with high percentage of recurrent bleeding (37.5%). CONCLUSION: In our opinion helicobaceter pylori infection and decrease of local pH, which take place during the reaction of mucose on the presence of infection, are very aggressive factors which can cause bleeding erosions.

Adult↗
PubMedDate not supplied

[Tetrazepam in the treatment of painful muscle spasms].

The aim of the study was to examine myorelaxant and analgetic effects of tetrazepam using double-blind controlled random tests. The study comprised two groups of patients with 30 subjects in each with reflex muscle spasms in the lumbar and cervical spine. One group was treated with a nonsteroid analgetic and the another one with the combination of tetrazepam and a nonsteroid analgetic. The treatment lasted 15 days and the assessment using the standardized, graded scale was performed 0, 7 and 15 days after the onset of the treatment. More hematologic and biochemical parameters were analysed both at the beginning and completion of the treatment. The results of the study have shown that the combination of nonsteroid analgetics and tetrazepam achieved better and faster effects on pain and muscle spasms compared to nonsteroid analgetics with no significant side effects.

Adult↗
PubMedDate not supplied

[Immunochemical findings in the cerebrospinal fluid in patients with inflammatory demyelinating polyradiculoneuropathy].

The aim of the study was to check the hypothesis of involvement of the structure of the central nervous system on the basis of the analysis of the integrity of blood-brain barrier and the degree of IgG synthesis in the intrathecal space of patients with inflammatory demyelinization polyradiculoneuropathy. The study involved 27 patients with acute and 14 patients with chronic inflammatory demyelinization polyradiculoneuropathy. The analysis of liquor was performed in different stages of the disease. The results have shown that in the acute phase, in the phase of the maximal functional deficit there are signs of damaged integrity of the blood-brain barrier but without signs of increased intrathecal IgG synthesis. It has been concluded that there are no reliable signs of increased immunologic activity in the intrathecal space of patients with inflammatory demyelinization polyradiculoneuropathy.

Adult↗
PubMedDate not supplied

[Treatment of peripheral paresis-paralysis of the facial nerve using corticosteroids].

The study comprised 113 patients with Bell's paresis-paralysis of the facial nerve. This group was considered as experimental while the control group involved patients with the same disease treated with oral corticosteroids. In both groups physical therapy has been applied from the very beginning of therapy. The results of the study have shown that in the group of patients treated with local corticosteroids the complete recovery was found in 82% of cases, partial in 14% and no signs of recovery in 4%. The mean time of clinical and electrophysiologic recovery was 17 days. In the control group of patients the complete recovery was found in 50%, partial in 37.5% and no improvement in 12.5%. The significant influence on the time and degree of recovery in both groups, and especially in the first group, has the time of starting the therapy; if the therapy started in the first week after the onset of the disease, the recovery was usually complete in the first group.

Adult↗
PubMedDate not supplied

[Subfractions of high-density cholesterol lipoproteins in patients with ischemic cerebrovascular disorders].

Aiming to detect the most sensitive markers of increased risk of ischemic cerebrovascular diseases HDL, HDL2 and HDL3 cholesterol levels were examined using the ultracentrifugation method in 36 patients with acute brain infarction and 34 healthy subjects of the control group. The results of the study have shown significant reduction of the total HDL cholesterol levels in both subfractions, and especially of HDL3 in patients with brain infarction. This finding was discussed in the light of recent studies of lipid disorders in patients with ischemic cerebrovascular diseases. It has been concluded that further studies of these diseases should be directed toward apolipoproteins.

Acute Disease↗