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Biomedical subjects

V J Davies

Publications and source records attributed to V J Davies.

4 recordsLinked to original sources
PubMed1992

Transfusion of frozen thawed blood stored at -20 degrees C to -25 degrees C.

OBJECTIVE: To determine the clinical efficacy of transfusion of frozen-thawed (FT) red cells using a 5-bag system for freezing (at -20 degrees C to -25 degrees C), storage and reconstitution. DESIGN: A prospective, controlled, non-randomised clinical trial was undertaken with two groups of orthopaedic surgical patients. Nine patients received FT homologous blood and a control group of 10 patients received homologous blood stored in liquid form at 4 degrees C. Five transfusion-dependent patients with medical conditions were also studied. OUTCOME: Thirty-three FT units were transfused without incident to 14 patients. In addition to clinical assessment, haematological and biochemical parameters were monitored after transfusion. There were no clinical side effects and laboratory data were consistent with those after recent surgery or for pre-existing medical conditions and subsequent blood transfusion. On the practical side certain technical difficulties were encountered which improved with experience. CONCLUSIONS: One of the major advantages of the system is the 35-day shelf-life at 4 degrees C after reconstitution. This system has potential for pre-deposit autologous collection, especially where large volume replacement may be required.

Aged↗
PubMed1989

Haemolysis induced by intravenously-administered immunoglobulin.

Two concurrent cases of haemolysis that was induced by intravenously-administered gamma-globulin are reported. Haemolysis, predominantly as a result of passively-acquired anti-A antibodies, occurred twice in one patient; anti-D antibodies also were incriminated in the first haemolytic episode. Passively-acquired anti-D antibodies that were found in the same batch of gamma-globulin contributed to the haemolytic episode in the second patient. These adverse reactions could have been prevented if a minor crossmatch procedure had been performed before the commencement of intravenous gamma-globulin therapy. It is considered important that manufacturers of intravenously-administered gamma-globulin preparations decide safe titres of these alloantibodies, and that suitable volumes be dispatched with each batch to enable a minor crossmatch procedure to be performed.

Adult↗
PubMed1989

High-grade non-Hodgkin's lymphoma complicating polypoid nodular lymphoid hyperplasia and multiple lymphomatous polyposis of the intestine.

Three patients with multiple lymphoid polyps of the small intestine--two with nodular lymphoid hyperplasia and one with multiple lymphomatous polyposis--developed high-grade B-cell lymphomas. A literature search has revealed only 10 previous cases of nodular lymphoid hyperplasia complicated by lymphoma and none of an association between multiple lymphomatous polyposis and high-grade lymphoma.

Adult↗