PubMed Health⌕ Search

Biomedical subjects

V J Jose

Publications and source records attributed to V J Jose.

9 recordsLinked to original sources
PubMed1989

A study of lipid levels in Indian patients with coronary arterial disease.

A detailed cross-sectional analysis of total cholesterol and triglyceride levels was studied in 1066 consecutive male patients who underwent selective coronary arteriography in our centre to confirm or exclude coronary arterial disease. There were 877 cases of coronary arterial disease and 189 patients with normal coronary arteries. Besides descriptive statistics of lipid levels in different age groups, percentile distribution was studied. Association characteristics between lipids and other risk factors was studied by multiple regression analysis. Relative risk of lipids, controlling for the confounding variable of age as well as weight was obtained using the Mantel Haenszel chi square procedure. Results revealed the occurrence of coronary artery disease with low lipid levels in our population. The 50th percentile for total cholesterol was 205 mg/dl for the cases and 186 mg/dl for controls, while for triglycerides it was 158 mg/dl for cases and 140 mg/dl for controls. Multiple regression analysis of smoking, positive family history, diabetes, hypertension, weight and age contributed a low R square value of 2.49% for cholesterol and 4.22% for triglycerides in the cases and controls. The Mantel Haenszel chi square test procedure confirmed that low lipid levels could be seen irrespective of the age or weight of individuals. It is speculated that other factors which may include ageing, metabolic or immunologic components yet to be ascertained, could contribute additionally, to atherosclerotic coronary arterial disease in our population.

Adult↗
PubMed1989

Electrocardiographic left atrial enlargement--correlation with echo.

To assess the utility of electrocardiogram in identifying left atrial enlargement, electrocardiogram of 600 consecutive patients were correlated with their M-mode echocardiographic findings. Left atrial enlargement, as reflected by P terminal force in V1 had sensitivity of 79%, specificity 91%, predictive value 85% and accuracy of 86%. Patients older than 30 years with large left atrium (greater than 5.0 cm) had atrial fibrillation more frequently than younger patients (P less than 0.001). It is concluded that P terminal force in V1 is a reliable indicator of left atrial enlargement.

Adult↗
PubMed1989

Severity of mitral regurgitation in mitral valve prolapse syndrome. A Doppler echocardiographic study.

Thirty-three consecutive patients with mitral valve prolapse with a systolic murmur were evaluated using pulsed doppler echocardiography to quantify the severity of mitral regurgitation. There were thirteen (39%) patients with mild regurgitation, twelve patients (36%) with moderate regurgitation and eight patients (24%) with severe regurgitation. It was noticed that, all the patients with severe regurgitation had posterior leaflet prolapse. In contrast, patients with anterior leaflet prolapse had either mild or moderate regurgitation only. Our results suggest that the degree of mitral regurgitation differs depending on the leaflet that shows the prolapse, which may be of importance in the followup of patients with mitral valve prolapse.

Adult↗
PubMedDate not supplied

Neonatal pulmonary flow pattern--a pulsed Doppler echo study.

The pulmonary flow pattern was analysed by pulsed Doppler in 77 normal neonates, at < 48 hours (36 subjects), 49 to 96 hours (25 subjects) and 97 to 148 hours (16 subjects). From the flow velocity spectrum, using an built in computer system, the acceleration time and the ejection time were measured, and the ratio was calculated. This ratio was 0.24 +/- 0.08 in the subjects within 48 hours whereas this ratio was 0.53 +/- 0.11 in the subjects above 97 hours; thus the ratio increased with age. We noticed that the ratio obtained from the pulsed Doppler is useful in assessing the pulmonary vascular status, even in neonates.

Blood Flow Velocity↗
PubMedDate not supplied

Right ventricular filling abnormalities in acute inferior wall myocardial infarction--a pulsed Doppler study.

Pulsed Doppler derived velocity profile of right ventricular filling was used to assess right ventricular diastolic function in 29 patients with acute inferior wall myocardial infarction. The peak velocities of the early filling wave 'E' and the atrial wave 'A' were measured. Diastolic dysfunction, defined as E/A ratio less than 1.0, was seen in 15 patients. Of these 15 patients, 9 had electrocardiographic evidence of right ventricular infarction and only 6 had clinical evidence of right ventricular failure. None of the 14 patients without right ventricular diastolic dysfunction (E/A ratio more than 1.0) had electrocardiographic evidence of right ventricular infarction or clinical evidence of right ventricular failure. Pulsed Doppler appears to be a sensitive technique in identifying hemodynamic derangements induced by right ventricular infarction.

Echocardiography, Doppler↗