Biomedical subjects
Publications and source records attributed to V J Patel.
Indications and results of conventional operative closure of iatrogenic vesicovaginal fistulas (24 patients) and exclusively endoscopic fibrin sealing (6 patients) have been reported. The primary closure rate of the first mentioned method is 88 per cent, but 66 per cent in cases of endoscopic fibrin sealing. The last method is reported in detail.
We report two cases of complex renal carcinoma in which retrograde transvenous perfusion cooling (RTPC) of the kidney was used as adjunct to in situ partial nephrectomy. Definite advantages seem to favour this technique of regional renal hypothermia. We are hopeful that RTPC of the kidney will in future allow to reduce the frequency of potentially harmful extracorporeal bench surgery with autotransplantation in the conservative management of renal carcinoma. Renal RTPC is applicable whenever the kidney is approached transperitoneally with preliminary exposure of the renal vascular pedicle. Tumour cell spill has to be discussed as possible complication of this method. Both patients are alive 25 and 19 months, respectively, after surgery without evidence of haematogenous, peritoneal or retroperitoneal tumour disease.
Suspension of Tantalum dust can be used as contrast material. It helps in producing X-ray films which are rich in contrast and details. The composition of the suspension and the technique of retrograde pyelography with the suspension is described.
The effectiveness of parasympathicolytic drugs in the treatment of ureteric colics is doubtful. Bencyclane is a new myotropic substance. Its spasmolytic effect on smooth muscle is five times stronger than that of papaverine. The results of the clinical use of Bencyclane in cases of ureteric colic are described and discussed.
Differential diagnosis of small tumors of the ureter and renal pelvis is often difficult. Retrograde pyelogramm and tri-iodied contrast material is not effective in diagnosing small tumors and their surface condition. A retrograde pyelogram with a tantalum powder solution offers the following advantages: 1. Clearer representation of the tumor surface. 2. X-ray films show sharper contrast. 3. Small tumors could be seen that are not visible with routine contrast material. Preparation of tantalum solution and the technique of retrograde pyelogram are described.
It is reported on 124 patients in whom after a transvesical adenomectomy an early removal of the catheter was aspired to. A watertight closure of the urinary bladder is one of the most important prerequisites. The 5th day after operation seems to be best suited for the removal of the catheter. A temporary fistulisation lasting 2 days occurred only in one case. Secondary infection of the wound as well as epididymitis could not be observed. 96% of the patients could be discharged with sterile urine. Advantages of the early removal of the catheter: 1. Shortened hospitalisation and shortened convalesence. 2. Reduced danger of a secondary infection of the urinary tract 3. Early symptom-free subjective condition of the patient.
A rapid technique for quantitative separation of ribose-methylated nucleosides from base-methylated and non-methylated nucleosides by chromatography on DEAE-cellulose paper in the presence of borate is described. The method has been used as an assay for tRNA ribose methylases from yeast, using under methylated Escherichia coli tRNA as substrate. The main product formed with a partly purified yeast enzyme was characterized as 2'-O-methylcytidine.
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