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V J Zarro

Publications and source records attributed to V J Zarro.

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Quantitative gait analysis in unilateral and bilateral total hip replacements.

By qualitative and quantitative analysis of gait we evaluated the outcomes in 41 patients after total hip arthroplasty for degenerative arthritis. Patients with unilateral and bilateral degenerative hip disease were evaluated in an effort to characterize preoperative and postoperative gait characteristics. Patients were evaluated using a subjective hip-rating scale and a gait-evaluation mat. Data were compared with those obtained from a control group of 91 patients. All patients showed a marked improvement in both subjective ratings and measured quantitative gait parameters. Patients with unilateral hip disease improved to a greater extent than those with bilateral disease after arthroplasty. We have concluded that total hip arthroplasty can greatly improve the gait characteristics of patients with degenerative arthritis, and that this improvement can be quantified, documented, and followed by using a system of gait evaluation.

Follow-Up Studies

Quantitative gait analysis after unilateral or bilateral total knee replacement.

Using a gait mat, we characterized the functional results for thirty-five patients before and after a total knee replacement for the treatment of degenerative arthritis. Preoperatively, we studied three distinct populations of patients. Group I consisted of sixteen patients who were scheduled to have a unilateral total knee replacement and who had no signs or symptoms of arthritis in the contralateral knee. Group II consisted of twelve patients who were scheduled to have a unilateral total knee replacement but who had asymptomatic degenerative arthritis in the contralateral knee. Group III consisted of seven patients who had bilateral arthritis that was to be managed by total knee replacement. The gait mat allowed us to measure stance time, step length, double-support time, swing time, swing-to-stance ratio, and velocity. A knee-rating scale was used to measure pain. The data were compared with those obtained from an age-matched control group of ninety-one subjects. Postoperatively, the gait evaluation revealed marked improvement in all of the patients. However, the patients in Group II did not improve as much as those in Groups I and III did. We concluded that even asymptomatic arthritis can impair gait, that bilateral total knee replacement can yield excellent results, and that patients tend to use the lower limbs in as symmetrical a way as possible. Gait analysis can be an important source of objective information, and it is easily performed by using a gait mat.

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Study of two acetylcholine analogs with fixed conformations.

Two acetylcholine analogs, compound M (4,4-dimethyl-2-morpholonium) and compound P (1,1-dimethyl-3-acetoxypiperidinium) which contain the N-C-C-O group of acetylcholine fixed in the gauche and trans conformations, respectively, were tested for activity on the terminal ileum of the rat, the rectus abdominis muscle of the frog, and the superior cervical ganglion of the cat. It was found that compound M stimulates the ganglion but has no affinity for receptors in either the ileum or the rectus muscle, while compound P stimulates cholinergic receptors in the ileum and in the fast fibers of the rectus muscle but acts neither on the slow fibers of the rectus muscle nor on the ganglion.

Acetylcholine