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Biomedical subjects

V Järvinen

Publications and source records attributed to V Järvinen.

At least 19 recordsLinked to original sources

Bulimia and tooth erosion.

Eating disorders are often associated with regurgitation of gastric contents into the mouth and dental erosion. In this study the dental status was evaluated in bulimic patients. Thirty-five bulimics, diagnosed in the Outpatient Departments of Psychiatry and Adolescent Psychiatry of the University Central Hospital in Helsinki, and 105 controls matched for age, sex, and educational level were examined clinically, and the factors associated with dental erosion and caries were evaluated in an interview. Severe dental erosion and dental caries were significantly commoner among bulimics than controls. Bulimics commonly had a low salivary flow rate, but other apparent risk factors of dental erosion did not differ from those of controls. A feeling of dry mouth was commoner among bulimics than controls, and bulimics had an increased tooth sensitivity to cold and touch. More should be done to protect teeth from dental erosion among bulimics, because loss of tooth tissue remains even if the eating disorder disappears.

Adult↗

Bilateral diaphragmatic weakness: a late complication of radiotherapy.

Brachial plexus neuropathy is an unfortunate complication that sometimes follows radiotherapy to the axillary and supraclavicular regions. A patient is described who, 30 years after radiotherapy for Hodgkin's disease and more than 10 years after the development of radiation-induced bilateral brachial plexus neuropathy, presented with bilateral diaphragmatic weakness secondary to bilateral phrenic nerve weakness. Previous radiotherapy was the most probable cause of the condition.

Aged↗

Assessment of right and left atrial function in patients with transplanted hearts with the use of magnetic resonance imaging.

BACKGROUND: The purpose of this study was to determine the volumes and cyclic volume changes of the cardiac atria after heart transplantation in physically healthy recipients. METHODS: Ten heart transplant recipients (New York Heart Association grade I) entered the protocol. All operations had been made with classic biatrial anastomoses. Eight healthy volunteers were studied as controls. To measure the volumes of both atria and left ventricular cavity, we used a gradient-echo cine sequence. The 10 mm slices covered both atria over the total cardiac cycle. Images were planimetered, and simultaneous volumes were totalled to give the cavity volume at each time phase. RESULTS: The heart rate of the heart transplant recipients was faster than in controls, which resulted in higher cardiac output. The atrial minimum volumes were significantly larger, and fractional emptying was smaller in transplanted hearts when compared with controls. Reservoir and stroke volumes were smaller and conduit volumes were larger in transplanted hearts than in controls. The atrial filling and emptying rates were lower in heart transplant recipients than in controls. CONCLUSIONS: The classic surgical technique used in heart transplantation results in large atria with decreased volume changes and filling rates even in physically healthy transplant recipients. Magnetic resonance imaging is a reliable tool in assessment of atrial volumes and cyclic function after heart transplantation.

Adult↗

Skewness of instantaneous mitral transannular flow-velocity profiles in normal humans.

The spatial distribution of instantaneous diastolic flow velocities across the mitral annulus was studied with cardiac gated cine magnetic resonance imaging in 10 healthy persons aged 26-46 yr. Velocity encoding used two interleaved gradient echo pulse sequences with velocity sensitivity in the direction of flow perpendicular to the annular imaging plane. Velocity maps were reconstructed at 30- to 43-ms intervals throughout diastole. Velocity-time curves and mean flow rates were determined in five regions of the mitral annulus using a 0.6-cm2 measurement area. The spatial velocity minimum was consistently in the anterolateral commissural area, whereas the maximum was in the anterior annulus in early diastole shifting posteromedially in late diastole. The mean flow rate (+/- SD) averaged 18.4 +/- 8.1 ml.s-1.cm-2 of annular area centrally, 18.3 +/- 7.2 ml.s-1.cm-2 anteriorly, 16.9 +/- 7.4 ml.s-1.cm-2 posteriorly, 13.0 +/- 7.7 ml.s-1.cm-2 in the anterolateral commissural area, and 23.0 +/- 7.3 ml.s-1.cm-2 in the posteromedial commissural area (P < 0.001). We conclude that mitral transannular flow shows marked spatial inhomogeneity in normal humans. The skewness of flow profiles compromises the use of local velocity measurements as indexes of left ventricular filling.

Adult↗

Occupational syrup-tasting and dental health.

In the sugar industry the quality of a syrup is judged by taste. The aim of this study was to investigate whether tasting affected the taster's teeth. Seven technicians who had tasted syrups for at least 2 years and 21 age-matched controls working in the same factory were investigated. Dental, medical, and dietary histories were obtained, and salivary and intra-oral examinations were undertaken. The tasters had similar DMFS indices to but more decayed surfaces than the controls (3.4 versus 1.0; p < 0.05), especially on proximal surfaces (2.0 versus 0.7; p < 0.05). The tasters had also higher visible plaque index and gingival bleeding index than the controls (23% versus 11% and 23% versus 10%; p < 0.05). We conclude that frequent exposure to syrup may increase caries activity, despite the various preventive measures commonly adopted. It is concluded that those selected for tasting should be carefully examined for general health and oral status and that preventive dental measures be emphasized.

Adult↗

Location of dental erosion in a referred population.

The aim of the study reported here was to determine locations of dental erosion and whether or not it is possible to decide the cause of erosion from the location. One hundred and six patients with dental erosion, 54 men and 52 women, mean age of 33.6 years, were studied. Erosion was classified as one of three grades on buccal, lingual or occlusal/incisal surfaces. Dietary and gastric causes of erosion were identified by means of a questionnaire. Erosion was observed on all teeth, but was commonest on the upper incisors, canines and premolars, and severest on palatal surfaces. In both groups, in which erosion had gastric and dietary causes, there were cases of buccal, lingual and occlusal erosion, but the risk of lingual erosion was 1.9 times greater in the group in which erosion had a gastric cause than in the group in which erosion had a dietary cause. Our findings indicate, however, that the cause of dental erosion cannot reliably be identified by location of the lesion.

Adolescent↗

Experimental sports drinks with minimal dental erosion effect.

The effects of new experimental sports drinks on dental enamel were studied in vitro using bovine tooth specimens. Profilometric analysis was used to measure the loss of tooth material after immersion of the specimens in the drinks. Thereafter the specimens' surface hardness was measured and scanning electron microphotographs were taken. In addition, 13 commercial sports drinks and experimental drinks containing either citric acid or malic acid were tested for their capacity to dissolve hydroxyapatite in vitro. The erosive effect increased markedly with decreasing pH. The citric acid containing drinks were more erosive than malic acid containing drinks. No erosion was observed with the malic acid containing drink (pH 5.90) but the drink of similar composition containing citric acid caused an erosion 1.3 +/- 1.1 microns deep and a commercial citric acid containing drink caused a lesion 12.3 +/- 4.5 microns deep after 120 min immersion. Softening of enamel was greater in specimens immersed in citric acid than in those immersed in malic acid containing drink. The in vitro hydroxyapatite dissolving effect of the commercial sports drink samples studied (all having a pH under 4.22) was markedly greater (0.48-4.38 mmol/l) than that of the malic acid containing experimental drink (pH 5.50, Ca++ concentration in the supernatant 0.19 mmol/l) and of the similar citric acid containing drink (0.35 mmol/l). The hydroxyapatite dissolving effect of both drinks started to be marked at a pH level of about 5.0 but increased thereafter exponentially with decreasing pH. At pH levels above 4.0 the hydroxyapatite dissolving effect of citric acid containing drinks was greater than that of malic acid containing drinks.

Animals↗

Dental erosion and upper gastrointestinal disorders.

The orodental status, particularly dental erosions, of 109 patients with upper gastrointestinal symptoms was examined. In 44 patients, the underlying pathosis was associated with increased acid output in the stomach (reflux esophagitis or duodenal ulcer), while in 48 patients who underwent cholecystectomy, the duodenogastric reflux was alkaline. In 17 patients with gastric ulcer, the gastric secretion was usually normal. The diagnoses were made with gastroscopy. Seven patients with dental erosion were found, and they all came from the group of 35 dental patients with reflux esophagitis or duodenal ulcer. No erosions were seen in the other diagnostic groups (F = 0.02). Thus, gastrointestinal disorders with increased output of gastric acid may be linked with dental erosions. The finding emphasizes the need for accurate diagnosis and appropriate treatment of patients with upper gastrointestinal symptoms in order to avoid irreversible lesions in the teeth.

Adult↗

Lead content of deciduous molar enamel in Finland, as measured by proton-induced X-ray emission.

The lead content of deciduous molar enamel was measured with an accurate physical technique based on proton-induced X-ray emission. The absolute values were calibrated according to the animal bone standard of the International Atomic Energy Agency. The results obtained from five different communities indicated little difference between communities in the lead content of the deciduous molar enamel of children born in 1960-1975. The overall mean for all samples analyzed was 3.2 (SD 1.6) micrograms/g (N = 120); the highest individual value measured was 10.0 micrograms/g. Judging from the lead content of the teeth, the general population in Finland does not yet seem to be exposed to detectably higher amounts of artificially occurring environmental lead, neither in urban nor in rural areas. It would seem that naturally occurring environmental lead still plays a decisive role in the integrated long-term exposure in Finland.

Child↗

44-year dental health survey of Helsinki schoolchildren.

The purpose of the present study was to establish whether the number of intact teeth in Helsinki schoolchildren aged 7-13 years was rationally correlated with the wartime reduction in sugar consumption and, later, with dental health education programs in Finland. The period covered is 44 years. The results show that dental health education is effective in caries prevention and that enforced programs can lead to an improvement similar to that seen during the war.

Adolescent↗

Variation in caries recording and restorative treatment plan among university teachers.

Ten voluntary dental students were examined by 12 teachers at the same dental clinic. Eleven items of data were subjected to a two-way analysis of variance: missing teeth, filled teeth, filled teeth surfaces, DMF and DMFS index scores, decayed surfaces (first (C 1) and second (C 2) degree caries), decayed surfaces (C 2 only), decayed approximal surfaces (C 2), decayed occlusal surfaces (C 2), decayed smooth surfaces (C 2), and teeth considered to require treatment. Significant differences were found between the subjects for all 11 items assessed. The differences between the examiners were not significant for missing teeth, filled teeth, filled surfaces, and decayed smooth surfaces, but for the other items the between-examiner variation was significant at the level P less than 0.01. In particular, great variation was found in the plans for reparative care. It is suggested that teachers should undergo a special training program in order to make more consistent clinical judgments and hence to reduce the between-dentist variation in postgraduate clinical practice. This would probably be beneficial to the patients.

Adult↗