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Biomedical subjects

V Jagadeesan

Publications and source records attributed to V Jagadeesan.

14 recordsLinked to original sources
PubMed1991

Effect of administration of Aroclor 1254 on the activities of hepatic drug metabolizing enzymes in zinc deficiency.

In order to understand the mechanisms of carcinogenesis in zinc deficiency, a study was conducted in experimental animals to investigate the effect of administration of an inducer. After the production of zinc deficiency in NIN/Wistar strain of rats by feeding an egg albumin-starch based diet almost devoid of zinc, the animals were administered a potent inducer of mixed-function oxidases: Aroclor 1254 and various Phase I and Phase II enzymes of drug metabolism like benzo[a]pyrene hydroxylase, microsomal epoxide hydrolase, cytosolic epoxide hydrolase, and cytosolic glutathione-S-transferase studied in liver tissues. Control and pair-fed groups were also run alongside. The results showed that while the activities of various enzymes studied were low in the uninduced basal condition, these activities increased many-fold after induction. This induction was observed not only in the control group, but in the pair-fed and deficient groups as well. These results suggest that the ability to respond to a carcinogenic insult, though initially present in zinc deficiency, may not be adequate to counteract an excess or chronic exposure to carcinogen in the long run.

Animals↗
PubMed1989

Effect of food restriction on benzo(a)pyrene binding to DNA in Wistar rats.

A study was carried out to assess the binding of the carcinogen benzo[a]pyrene to DNA in different tissues under in vivo and in vitro conditions in Wistar rats which have been subjected to different levels of food restriction. The results showed that there was a significant increase in the binding of benzo[a]pyrene to hepatic DNA in food restricted animals in in vivo experimentation although this was not observed under in vitro conditions. There was a decrease in binding to pulmonary DNA and no change for renal DNA.

Animals↗
PubMed1989

Study of activating and conjugating enzymes of drug metabolism in zinc deficiency.

A study was undertaken to investigate the activities of certain enzymes of drug metabolism in zinc deficiency. For this purpose, an experimental model for zinc deficiency was produced in a NIN/Wistar strain of rats by feeding an egg albumin-starch based diet. Of the two enzymes of Phase I pathway of drug metabolism studied, Benz (alpha) pyrene hydroxylase was altered in zinc deficiency and food restriction; the other one microsomal epoxide hydrolase was unchanged. The activity of glutathione-S-transferase, a key enzyme in conjugation reaction was significantly lowered in zinc deficiency as well as food restriction. These alterations in the activities of xenobiotic metabolising enzymes are discussed with reference to toxicity manifestation in zinc deficiency.

Animals↗
PubMed1988

Serum complement levels in normal pregnancy and pregnancy-induced hypertension.

Serum complement assay (CH50) was carried out in urban low-income women belonging to the following groups: (i) non-pregnant and non-lactating women; (ii) pregnant women in different periods of gestation; (iii) women suffering from pregnancy-induced hypertension. Serum CH50 titers showed significant increase in the second and third trimester pregnancies as compared to non-pregnant, non-lactating women. There were no differences in CH50 levels between women suffering from pregnancy-induced hypertension and those with normal pregnancy of comparable period of gestation. Nutritional status did not seem to have any influence on complement titers.

Complement System Proteins↗
PubMed1988

Effects of dietary zinc deficiency on the activity of enzymes associated with phase I and II of drug metabolism in Fischer-344 rats: activities of drug metabolising enzymes in zinc deficiency.

A study was undertaken to assay the various phase I and phase II drug metabolising enzymes in zinc deficiency. Male weanling Fischer rats were subjected to zinc deficiency for a period of 7 weeks. Zinc levels in the control and deficient diets were 30 mg and 1.1 mg/kg diet, respectively. At the end of the experimental period, the activities of various hepatic cytosolic and microsomal enzymes were estimated. It was observed that the activities of microsomal epoxide hydrolase (with benz(a)pyrene 4-5 oxide as substrate), uridine diphospho glucuronyl transferase (with 1-naphthol as substrate) and cytosolic glutathione-S-transferase (with chlorodinitrobenzene as substrate) were altered exclusively due to zinc deficiency. There was a change in the activities of the following enzymes, which could be due either to zinc deficiency and/or food restriction: 1) aryl hydrocarbon hydroxylase; 2) cytochrome b; 3) cytochrome c; and 4) cytochrome b5. Other enzymes studied, i.e., cytosolic epoxide hydrolases, microsomal EHSTO, and UDPGT testosterone were not different in the control and experimental groups. The results are discussed in relation to the activation of carcinogens and neoplastic formation in zinc deficiency.

Animals↗
PubMed1985

Drug binding in the undernourished: a study of the binding of propranolol to alpha 1-acid glycoprotein.

The binding of propranolol, a drug commonly used in cardiovascular disorders, to alpha 1-acid glycoprotein (AGP) was studied in vitro in malnutrition. Compared to normal and hospital controls, the level of AGP was found to be elevated in undernourished subjects with and without infection. In the same patients the free drug percentage was significantly diminished. A significant inverse relationship was observed between the percentage of free drug and the level of AGP. The finding suggests that there may be need for an altered dosage regimen in the undernourished.

Humans↗
PubMed1979

Immune studies in oral contraceptive users.

Some of the parameters of immune status-percentage of B and T lymphocyte subpopulation, PHA-induced lymphocyte transformation measured by 3H-thymidine incorporation (PILT) and levels of total haemolytic complement (CH5O) were studied in Indian women from low income group who were using estrogen-progestogen combination pills. There were no differences in percentage of B and T lymphocyte subpopulation or PILT between OC users and the control group. However, CH5O levels were significantly lower in OC users. The depression in circulating complement levels in OC users is intriguing and suggests the possibility that complement system and circulating immune complexes may be altered in OC users.

Adult↗
PubMed1978

Interrelationship between vitamins E and A: a clinical study.

Plasma vitamin A and vitamin E levels were determined in 45 children. Seven normal children and 7 children with vitamin A deficiency were given daily supplements of 100 mg vitamin E for two weeks. Seven others received a placebo and served as controls. The mean levels of plasma vitamin E and A were 694 microgram/dl and 21 microgram/dl respectively. There was no correlation between plasma levels of the two vitamins. Administration of vitamin E resulted in a significant increase in plasma vitamin A concentration both in normal children and in those with vitamin A deficiency, while there was no change in the control group.

Child↗
PubMed1978

C3 in human milk.

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Complement C3↗
PubMed1977

Antimicrobial factors in human milk.

Levels of immunoglobulins, lactoferrin and lysozyme were determined in milk samples obtained from well-nourished and under-nourished Indian women at different stages of lactation. The concentration of immunoglobulins and lactoferrin was higher in colostrum than in mature milk while the lysozyme levels showed a progressive increase with the period of lactation. There were no significant differences in the levels between the two groups of women. Administration of iron did not alter either the total or percentage saturation of lactoferrin in milk. These results indicate that antibacterial factors in milk are not influenced by the nutritional status of the mother and that iron supplementation does not interfere with the bacteriostatic function of lactoferrin.

Colostrum↗
PubMed1976

Functional significance of growth retardation in malnutrition.

Various functional parameters involved in resistance to infection were investigated in children suffering from varying grades of protein-calorie malnutrition. It was observed that the phagocytic function was impaired in children whose weights were below 80% of the Indian Council of Medical Research standard, whereas the cell-mediated immune response was altered in those with weights below 70% of the standard. Antibody response to typhoid antigen was impaired in children with severe protein-calorie malnutrition, while the response to diphtheria and tetanus toxoids was normal in all. These observations suggest that malnourished children whose weights are below 80% of the Indian standard are likely to suffer from at least one functional handicap which may increase the risk of infection. In any action-oriented program, priority should, therefore, be given to this group of children.

Antibodies↗