PubMed Health⌕ Search

Biomedical subjects

V K Agarwal

Publications and source records attributed to V K Agarwal.

At least 19 recordsLinked to original sources
PubMed1992

High-performance liquid chromatographic methods for the determination of sulfonamides in tissue, milk and eggs.

In the last decade, significant research has been done to improve the existing high-performance liquid chromatographic (HPLC) methods and also towards developing simple, reliable and sensitive HPLC methods for sulfonamides in meat, milk and eggs. The replacement of solvent extraction with solid-phase extraction or matrix solid-phase dispersion techniques is a step forward. Significant improvements in sensitivity have been achieved. This review concentrates on HPLC methods for the determination of sulfonamides in foods of animal origin published after 1980. The existing methods are critically evaluated and suggestions for future research are made.

Animals↗
PubMed1992

Surgical manifestations of ascariasis in childhood.

Amongst 50 patients with surgical complications of Ascaris lumbricoides 35 patients (70%) were treated conservatively and 15 patients (30%) required surgical intervention which included squeezing of worms to distal colon, resection and anastomosis of ileum, appendicectomy and peritoneal lavage. Intestinal perforation was observed in 3 cases. Two patients (4%) died because of postoperative complications. Those presenting with subacute intestinal obstruction had no mortality or morbidity. Although a large number of roundworms were seen in the jejunum, the obstruction was generally observed in the distal ileum.

Anthelmintics↗
PubMed1990

A new procedure for the isomerization of vitamin D and its metabolites.

A new procedure for the isomerization of vitamin D and its metabolites is described. Vitamin D or its metabolites are dissolved in 100 microliters methanol and 10 M HC1 in 2-butanol is used as the reagent for isomerization. The isomerization reaction is carried out at 5 degrees C for 2-3 min which gives quantitative yields of isotachysterols down to 10 ng level without use of any carrier.

Calcifediol↗
PubMed1989

Comparative antifilarial efficacy of the N-oxides of diethylcarbamazine and two of its analogues.

The N-oxides of 1-diethyl carbamoyl-4-methyl piperazine (DEC), 3-ethyl-8-methyl, 1,3,8-triazabicyclo (4,4,0) decan-2-one (centperazine) and 1-methyl-4-(pyrrolidin-1-yl-carbonyl) piperazine (CDRI Comp. 72/70) have been evaluated against Limotosoides carinii infection in cotton rats to establish whether conversion of the three antifilarials into N-oxides would lead to exertion of better antifilarial activity. Of the three N-oxides, N-oxide of DEC showed significantly more suppressive effect on circulating microfilariae in comparison to its parent compound. However, adult worms were unaffected. It was observed that basicity of the N-CH3 group did not play major role in exertion of activity of DEC and related compounds. Nevertheless, two other N-oxides were inactive.

Animals↗
PubMed1981

Relationship of serum guanase levels with economic characters in Zebu purebred and temperate x Zebu crossbred dairy cattle.

Serum guanase levels of Indian Zebu (Hariana) cattle and its crosses with different exotic levels of temperate breeds of dairy cattle were estimated in 527 animals, and their associations with economic characters were determined. The overall mean value of serum guanase level was 13.46 +/- 0.45 IU/ml of serum. An inverse relationship between the concentration of the enzyme and the frequency of cattle falling within a definite range was observed, as over 75% of the animals possessed 1 to 20 IU/ml of serum guanase. An analysis of variance revealed significant differences (P less than 0.01) in enzyme levels among different genetic groups under study. Hariana (Zebu) purebreds had significantly higher enzyme levels (19.60 +/- 1.85) than any of the crossbred groups, whose enzyme levels ranged from 8.99 +/- 1.41 in Red Dane F1 half-breds to 14.30 +/- 1.11 in Brown Swiss F1 half-breds. The correlation and regression coefficients were significantly positive for reproductive traits such as age at first service and age at first calving, and significantly negative for production traits such as lactation yield and lactation length. These results suggest that selection of dairy cattle based on low serum guanase levels might result in correlated improvements in dairy cattle productivity.

Aminohydrolases↗
PubMed1980

Intrathecal antitetanus serum (horse) with steroid in the treatment of neonatal tetanus.

107 patients with neonatal tetanus were studied and the value of intrathecal antitetanus serum with steroid was noted. The mortality rate in a control group (68%) was significantly higher than that of the test group (37%). Furthermore, a delay in antitetanus serum administration was found to have a strong positive linear correlation with the mortality rate. In fact, the mortality rate for neonates who were given antitetanus serum 24 hours after the onset of convulsions was found to be as high as for the control group. This suggests that intrathecal antitetanus serum is ineffective unless it is administered within 24 hours of the onset of convulsions. There was no significant difference in mortality rate whether a dose of 100 units or one of 50 units antitetanus serum was given intrathecally. The mean duration in hospital for survivals of the test group (7.4 days) was significantly shorter than that for survivals of the control group (10.4 days). No complication of intrathecal antitetanus serum was observed during the study.

Animals↗