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V K Chopra

Publications and source records attributed to V K Chopra.

11 recordsLinked to original sources
PubMed1980

Biological damage in spleen by iodine-125 in potassium perchlorate blocked thyroid of rats.

Studies on spleen have been performed following administration of iodine-125 in perchlorate-treated rats. Although DNA levels did not change appreciably, there was a significant decrease in total RNA following incorporation of iodine-125. Associated with the changes in RNA, there was a significant rise in acid phosphatase and total as well as Mg-dependent ATPases. Increased activity of acid phosphatase seems to be related to the loss of lymphocytes, whereas the rise in ATPase appeared to be associated with cells of red pulp of spleen. It is suggested that damage to the spleen after administration of iodine-125 is due to the Auger effect.

Acid Phosphatase↗
PubMed1980

Evaluation of a simpler technique for in-vivo labelling of red blood cells with 99mTc.

The efficiency of labelling red blood cells with intravenously administered 99mTcO4, by prior oral administration of stannous chloride dihydrate, has been evaluated. Optimum labelling occurred 1 hr after the oral dose of 200 mg of SnCl2.2 H2O and 20 min after the intravenous injection of 99mTcO4. The mechanism of labelling has been shown to be diffusion of 99Tc through the cell membrane followed by binding to haemoglobin in the presence of reducing agent. The in-vivo labelling technique has been found to be useful for the diagnosis of an abdominal mass and for static perfusion studies.

Administration, Oral↗
PubMed1977

Biological damage in testis by iodine-125 in partially blocked thyroid of rats.

Degeneration of testis has been observed after administration of Iodine-125 in potassiumperchlorate treated rats. Histological damage is associated with loss of DNA, RNA, acid phosphatase, total adenosine triphosphatase (ATPase) and Na/K dependent ATPase. Iodine-125 induced atrophic testis shows higher content of sodium and lower levels of potassium as compared to control testis. Damage of testis by Iodine-125 has been compared with atrophied testis, following gamma irradiation earlier reported. Auger effect due to Iodine-125 decay and transmutation at the sites of nuclei and plasma membrane of germinal cells seems to be the possible explanation for testicular damage caused by Iodine-125.

Acid Phosphatase↗