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Biomedical subjects

V K Frolov

Publications and source records attributed to V K Frolov.

At least 19 recordsLinked to original sources
PubMed1986

Pathogenetic and functional characterization of lymphocytes in influenza patients.

The kinetics of acrocentric chromosome associations and chromosome aberrations in peripheral blood and pleural exudate lymphocytes has been studied in 25 influenza patients and 7 exudative pleurisy patients. Lymphocytes without associations and with 2 associated acrocentric chromosomes were activated in the body, since their frequency appeared to be positively correlated with the immunoresponsiveness indices and with clinical symptoms. The number of these lymphocytes in pleural exudate was 2.5 times higher than in the peripheral blood. When comparing the frequency of chromosome aberrations in the patients' lymphocytes to the level of immunity, cytogenetic changes corresponded to the indices of cellular rather than humoral immunity.

Adolescent↗
PubMed1984

[Methodological and clinical aspects of radionuclide diagnosis of thyroid diseases].

A multimodality radionuclide study including thyroscintigraphy, thyroprofilography, radioimmunoassay to determine the levels of thyroid hormones and TSH in the blood serum, and a new method of radionuclide thyrochronoscopy, was conducted in 32 patients with diffuse and nodular enlargement of the thyroid and in 5 patients of the control group. Thyrochronoscopic results were used to determine the percentage of absorption of 99mTc-pertechnate by the thyroid on the 20th minute, exponential index of absorption and clearance index. Their values turned out elevated in the patients with hyperthyroidism and suspicion for hyperthyroidism. Three degrees of marked compensatory capabilities of the thyroid tissue were singled out in the patients with the euthyroid status. The study showed the diagnostic value of thyrochronoscopic findings in examining thyroid function. In this view the use of cross-sectional scanning proved to be less informative. Not in all the patients did the levels of thyroid hormones and TSH correlate with thyrochronoscopic findings because they make it possible to reveal the disturbance of the compensatory capabilities of the thyroid before the development of hormonal changes. The use of radionuclide thyrochronoscopy enhances the diagnostic efficacy of a comprehensive study of the thyroid.

Diagnosis, Differential↗
PubMed1977

The mechanism of group differences in the character of the vaccinal process in immunization against natural smallpox.

The effect of antigenic polymorphism of the ABO-system blood groups on the character of the vaccinal process after immunization against natural smallpox was investigated. The increased susceptibility of persons possessing A antigen to the harmful effect of smallpox vaccine virus is due to hereditary rather than to acquired factors. The leukocytes of peripheral blood of these persons showed a poorer binding capacity with respect to the smallpoxvaccine virus; they also exhibited a high rate of chromosomal aberration after vaccination, resulting to some extent from increased proliferative ability of the cells.

ABO Blood-Group System↗
PubMed1975

[Frequency of acrocentric chromosomal associations in children immunized with smallpox vaccine].

The frequency of associations of acrocentric chromosomes (AAC) diminished on the 7th day after vaccination in children primary vaccinated, primary revaccinated and secondary revaccinated against smallpox. This decrease reached its maximum by the 30th day and returned to its starting point after 6th months after vaccination. The degree of reduction of the frequency of AAC in every immunized children group correlated with the degree of increasing of antihemagglutinin titre. The relation of the number of group D chromosomes involved in AAC to the number of group G chromosomes varied in various individuals, these variations remaining after immunization. It was supposed that in PHA-stimulated lymphocyte cultures the degree of reduction of AAC frequency after vaccination against smallpox is a cytochemical marker of proliferation intensity of T-lymphocytes induced for immunopoiesis.

Antibodies, Viral↗
PubMed1975

Polymorphism of human blood groups and incidence of influenza A/Hong Kong (H3N2).

During three epidemics of influenza A/Hong Kong (H3N2) and experimentally in vaccines, the relation between influenza infection and ABo, Rh and MN blood groups was studied. Examinations of 2760 patients with laboratory-confirmed diagnosis of influenza and 749 persons vaccinated with live influenza vaccine showed that individuals of blood groups O and B were susceptible to influenza 1.67 and 1.20 times more, respectively, than individuals of blood group A. The difference in incidence was most manifested in first attacks and decreased in subsequent epidemics. The increased incidence in individuals of blood groups O and B as compared to those of blood group A was not associated with factors of specific (antibody) and nonspecific (interferon) resistance to influenza but was related to a greater capacity of leukocytes from these individuals to adsorb the virus. No relation between blood groups Ph and MN and incidence of influenza A/Hong Kong (H3N2) was established.

ABO Blood-Group System↗
PubMed1975

[Connection between the group factors of the blood systems ABO, MNSs, and rhesus and peculiarities of the vaccination process in children immunized against smallpox].

The ahthors present new data on the character of the vaccine process in children associated with the characteristics of the blood group ABO, MNSs and Rh systems. The greater frequency of occurrence and more manifest reactions were noted in children with blood groups A, B, AB, M and Rho (D) - in comparison with those having blood groups O, Rho (D) +, MN and N. There was a significant prevalence of chromosomal aberrations in the primarily immunized children with blood groups A in comparison with groups O, B and AB. The data obtained pointed to the negative effect of the mimi-rating antigens of the smallpox virus on the immunogenesis in smallpox. Search for methods of releasing the vaccine of these antigens is necessary for reduction of the reactogenic properties and increase of immunogenecity of the smallpox vaccines.

ABO Blood-Group System↗
PubMed1975

[Cytogenetic study of blood lymphocytes in children revaccinated against smallpox].

As the result of primary re-immunization with small-pox vaccine of eight years' old children chromosome aberrations were observed in their peripheral blood lymphocytes, the frequencies being 5.3% and 7.9% on the seventh day and in a month after the reimmunization respectively. Chromosome aberrations were significantly more rare in children with a high level of immunity retained after the preceding immunization as compared to those whose immunity was weakened with time. After the elapse of 6 months following the re-immunization the frequency of chromosome aberrationd did not exceed the initial level. The changes observed in the chromosome apparatus of lymphocytes are not specific for the small-pox vaccine alone, but are the evidence of the disturbance of homeostasis of the microorganism as the result of the effect of an alien antigen.

Child↗