Teratogenic risks of antiepileptic drugs.
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Biomedical subjects
Publications and source records attributed to V K Hiilesmaa.
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A series of 768 cases of primary invasive carcinoma of cervix was collected during the six years 1964--1969. This unselected material represents nearly one third of all new cases in Finland. The percentages of different stages (St) were: St I 49%, St. II 26%, St III 22% and St IV 3%. In comparison with earlier materials from our clinics an increase of St I was seen at the expense of St II. This probably results from increased use of the Papanicolau smear technique examinations. The incidence of St III and St IV was unchanged. Operative treatment combined usually with radiotherapy was used in 85% of the St I and in 38% of the St II cases. The remainder including those of St III--IV were treated by irradiation. The 5-year observed survival rates and relative survival rates (in brackets) were: St I 88% (92%), St II 51% (54%), St III 28% (31%), -t IV 0% and all stages together 63% (67%). A significant improvement in the 5-year results was found in the stages I and III when compared with the earlier material.