PubMed Health⌕ Search

Biomedical subjects

V K Jain

Publications and source records attributed to V K Jain.

At least 91 records · Page 5Linked to original sources
PubMed1991

Tissue level lymphocyte subpopulations in donovanosis.

Total T-, B-, T4-, and T8-lymphocyte populations were estimated in tissue sections of ulcers from 22 donovanosis patients, comprising 17 ulcerogranulomatous, four hypertrophic, and one sclerotic variants, using monoclonal antibodies and immunohistochemical technique (PAP). T- and B-lymphocytic infiltrations in the tissues were almost identical, without any significant difference in ulcerogranulomatous and hypertrophic variants. The T4:T8 ratio in ulcerogranulomatous variants, however, was 1.41, which was significantly higher than that of hypertrophic variants (1.28), indicating a greater cell-mediated immune response in the former than in the latter. This is substantiated by the documentation of a paucity of Donovan bodies, both in the tissue smear and slow (overnight) Giemsa-stained tissue sections, in the ulcerogranulomatous variant.

Aged↗
PubMed1991

Lipid-laden macrophages in bone marrow of leprosy patients.

While conducting a study to observe bone marrow cytomorphological changes in multibacillary leprosy, lipid laden macrophages as seen in sphingolipidoses were noted. The present study was planned to observe the occurrence and morphological characterization of these macrophages in various types of leprosy. Bone marrow records from 48 cases of paucibacillary and 72 cases of multibacillary leprosy were analysed. The macrophages accounting at the most for 3.5% of marrow cells were observed in 5 cases of paucibacillary and 43 cases of multibacillary leprosy with a maximum incidence being observed in patients with ENL (16/17). The lipid present in the cytoplasm of these cells could be derived from the lipid of the cell wall of Mycobacterium leprae. To the best of our knowledge, these cells have not been reported in leprosy so far.

Bone Marrow↗
PubMed1991

Fixed drug eruption of the oral mucous membrane.

Twenty-five patients with lesions of fixed drug eruption on the oral mucous membrane with or without cutaneous lesions were studied. Seventeen patients showed both cutaneous and oral mucous membrane involvement, while eight patients showed involvement of only the oral mucous membrane. Eighteen cases had bullous and erosive type of lesions while seven had lesions which were edematous and hyperpigmented with an erythematous halo. Diagnosis was confirmed in each case by provocation test. Cotrimoxazole, oxyphenbutazone and tetracycline were the most common causative drugs.

Adult↗
PubMed1991

Inadvertent penetrating injury to the globe with periocular corticosteroid injection.

We surveyed 488 physicians regarding their experience with inadvertent ocular penetration with steroid injections over a 5-year period. Sixty-six cases of ocular penetration were reported by the 209 physicians who responded. Of the 18 patients whose retinal status was known, 12 (67%) had retinal detachments resulting from the penetration. Final visual acuities in 85% of the 26 cases were worse than 20/100.

Adrenal Cortex Hormones↗
PubMed1990

Exophytic gliomas of the spinal cord.

Intradural extramedullary glial tumours of the spinal cord are rare. We report for such tumours arising from the dorsal cord. Myelography and operative findings were almost similar to that of an intradural neurofibroma. Surgical removal had resulted in rewarding neurological recovery. One of them had a recurrence after six years and was re-explored. Anterolateral attachment near the root entry zone suggests its origin probably from the spinal cord with an exophytic growth.

Adult↗
PubMed1990

Mesencephalic haematoma, successful surgical evacuation. Case report.

A case of mesencephalic haematoma is reported. Emergency surgical evacuation of haematoma was done. The patient improved and has done well for five years. Subtemporal and infratentorial supracerebellar approaches have been used earlier to remove mesencephalic haematoma. It is possible to remove caudal midbrain haematoma via a IVth ventricular approach causing minimal damage.

Brain Neoplasms↗
PubMed1990

Serum cholesterol binding reserve and its ratio to serum cholesterol in first degree relatives of patients with ischaemic heart disease.

Serum total cholesterol and serum cholesterol binding reserve (SCBR) were estimated in 50 healthy subjects and 25 cases with ischaemic heart disease (IHD) and their seventy asymptomatic first degree relatives. In normal subjects mean values of SCBR tended to expand with increasing levels of serum cholesterol, while this relationship was reversed in cases with IHD. The relatives showed a direct correlation between serum cholesterol and SCBR upto serum cholesterol level of 220 mg/dl, but the correlation was lost beyond this level. The critical levels for predicting risk of IHD were 30 mg/dl for SCBR and 8 for cholesterol: SCBR ratio. The latter was found to be a more sensitive index for predicting the risk of IHD as compared to SCBR alone.

Adult↗
PubMed1990

Right precordial mapping. Diagnostic sensitivity and specificity of leads V3R to V6R in different intercostal spaces in cases with right ventricular infarction.

Twelve lead conventional electrocardiography and right precordial mapping including precordial leads V2R to V6R in the 2nd to 5th intercostal spaces were obtained in 150 cases with acute myocardial infarction. There were 27 (18%) cases with right ventricular infarction: 24 associated with inferior wall infarction and 3 with anterior wall infarction. In the right precordial mapping, leads V3R to V6R in all intercostal spaces had equal sensitivity of 100%; 3rd intercostal space recording, however, had the maximum specificity of 92.6%.

Electrocardiography↗
PubMed1989

Intramedullary cysticercosis.

We are reporting two cases of intramedullary cysticercus cysts. Both patients presented with a clinical picture of progressive cord compression. One of them also had bilateral radicular pain. In the female patient the symptoms became exaggerated during her two consecutive pregnancies which is a rare and interesting observation. Excision of cyst resulted in significant improvement in both the patients.

Adult↗