Plastic reconstruction of longitudinal bone defects by means of compression and subsequent distraction.
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Biomedical subjects
Publications and source records attributed to V K Kamerin.
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Intensive synthesis of collagen, which constitutes the basis of organic matrix in bone tissue, was observed in the regenerate developed during compression-distractional osteoxynthesis. The organic matrix of the regenerate was quickly mineralized; after termination of the distraction it contained more than a half of calcium as compared with the mature bone of healthy animals. Relatively low accumulation of mucopolysaccharides in the regenerate appears to depend on development of favourable conditions of its blood supply together with suitable fixation of bone fragments.
Mature solid bone of dogs before an after substitution of diaphyseal defect using monolocal distraction osteosynthesis by Ilizarov as well as the growth zone and the ossified fragments of the regenerate produced were studied. In reparative osteogenesis proteoglycans and sialoproteins participated sequently in the management of calcification, as shown by analysis of specific correlations between mineral (calcium, phosphorus, carbonate and citrate) and organic components (collagen, non-collagenous proteins, hexuronic and sialic acids) in demineralized bone as well as in zones of the primary mineral deposition and crystallization, Solubilization of the complex of non-collagenous proteins and calcium phosphate might be important in demineralization of intact bone tissue of the animals studied.