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Biomedical subjects

V K Lazutin

Publications and source records attributed to V K Lazutin.

At least 19 recordsLinked to original sources
PubMed1991

[Clinical significance of arrhythmia in patients with hypertension].

Cardiac arrhythmias were studied in patients with essential hypertension in relation to their myocardial function. It was found that the arrhythmias occurring in the early period of the disease (borderline hypertension, Stage I hypertension) were primarily functional and affected the course of the disease and hemodynamics to a small degree. The life-threatening arrhythmias recorded in early hypertension were more commonly caused by mitral prolapse. The duration and severity of hypertension, development of left ventricular myocardial hypertrophy, myocardial fiber distension in relative heart failure play a decisive role in the development of cardiac arrhythmias in patients with Stage II hypertensive disease. It is essential to make comprehensive clinical and instrumental studies to clarify the genesis of the arrhythmic syndrome and to correctly choose the management policy in these patients.

Adult↗
PubMed1990

[Effectiveness of combined use of kontrykal and nitroglycerin in the acute period of myocardial infarction].

The natural history and extension of myocardial infarction were studied from parameters of precordial ECG in 35 leads and central hemodynamic findings in 100 patients with acute myocardial infarction. The least extension of myocardial lesion areas and better central hemodynamic parameters and a sharp reduction in the frequency of complications and hospital mortality in patients receiving a combined therapy with contrykal and nitroglycerin as a continuous long-term infusion within the first 24 hours of myocardial infarction as compared with the controls and in those having these agents alone.

Aged↗
PubMed1990

[Aortocoronary bypass in progressive stenocardia].

The authors evaluate the efficacy of aortocoronary shunting in the treatment of 10 patients with progressive angina pectoris (unstable stenocardia) in follow-up periods of up to 12 months after the operation. In none of the patients did angina pectoris or myocardial infarction develop in the indicated postoperative periods.

Adult↗
PubMed1990

[Aortocoronary shunting in patients with newly developed stenocardia].

Aorto-coronary bypass were performed in 10 patients aged from 34 to 55 years 7 to 30 days after the occurrence of angina pectoris for the first time. Coronarography demonstrated stenosis (of more than 75%) of the coronary arteries in all patients. Angina pectoris disappeared and did not recur in postoperative periods of up to 12 months in all cases. Shuntography was carried out 6 weeks after the operation in one patient: the shunt was potent.

Adult↗
PubMed1989

[Aortocoronary shunting in the early period after myocardial infarction].

Fourteen patients aged 34-54 years underwent aortocoronary bypass surgery for early postinfarction angina within 30 days following myocardial infarction. In periods up to 1.5 years after surgery, angina pectoris was not detected in the patients; cases of recurrent myocardial infarction were not registered.

Adult↗
PubMed1988

[Clinical effectiveness of ethacizine in various methods of intravenous administration].

Intravenous jet injections of 50 mg ethacizine (10 mg/min) are effective in 100% of cases of ventricular extrasystoles, and paroxysms of supraventricular and ventricular tachycardia, and in 59.5% of cases of atrial fibrillation paroxysms. A relationship has been demonstrated between the magnitude of therapeutic effect and the duration of atrial fibrillation as well as the type of underlying disease. The use of the drug is not justified in paroxysmal auricular flutter. Ethacizine is effective in 82.4% of patients with acute myocardial infarction, and in 65% of patients with other diseases. A similar effect was obtained with intravenous drip injections at the rate of 1.7 mg/min, while the incidence of side effects was reduced essentially. Therefore, drip injections of ethacizine are preferable for the treatment of heart rhythm disorders, such as extrasystoles, particularly in patients with acute myocardial infarction.

Adult↗
PubMed1987

[Use of nifedipine for treating heart failure in the subacute period of myocardial infarct in patients over 60].

The efficiency of nifedipine (an average daily dose of 34.7 +/- 0.2 mg) was examined in 19 patients between 60 and 81 years of age, with myocardial infarction aggravated by heart failure. Single and repeated nifedipine doses taken for 2 weeks produced a 7% drop in arterial BP, a 25% drop in peripheral resistance and a 18% rise in the cardiac index, mostly due to a 17% increase in the stroke index. A significant prolongation of left-ventricular ejection time and an improvement of myocardial contractility were due to smaller poststress and easier left-ventricular blood ejection. Nifedipine improved hemodynamic response to isometric handgrip exercise: peripheral resistance was lower, and the stroke and cardiac indices were higher at the peak of exercise after nifedipine administration, as compared to pretreatment values. Nifedipine is an effective agent for the treatment of postinfarction heart failure accompanied with high peripheral resistance.

Aged↗
PubMed1984

[Clinico-electrophysiologic study of the anti-arrhythmic action of trimecaine].

The antiarrhythmic activity of trimecaine hydrochloride administered orally and intramuscularly was studied in 58 patients with coronary heart disease accompanied by ventricular and supraventricular rhythm disorders. In 73.9% of the cases the drug exhibited antiarrhythmic action which was reflected in a longer period of the recovery of sinus node function, inhibited conduction in the atrioventricular node and a decreased time of intraatrial conduction. Side effects were observed in 17.3% of the cases mostly with the oral drug; they tended to abate spontaneously 2-4 h after trimecaine hydrochloride withdrawal.

Acetanilides↗
PubMed1981

[Use of contrical with heparin in the acute period of myocardial infarct].

The use of the methods of multiple (35) precordial ECG leads and serial tests for the activity of creatine phosphokinase and its MB fraction allows quantitative assessment of the dimensions of the necrotic zones. In injection of contrykal with heparin the dimensions of the myocardial infarct decreased. In early injection of these agents, the clinical and electrocardiographic findings improved more rapidly and the infarction zone was smaller. Injection of contrykal with heparin arrested the anginose attack more rapidly, corrected the peripheral symptoms of circulatory insufficiency, normalized arterial pressure and relieved the congestive phenomena in the lungs within a shorter period of time. The combined use of these agents is a pathogenetically substantiated method for the treatment of patients in the acute period of myocardial infarction for the purpose of restricting the dimensions of the ischemic damage to the myocardium.

Acute Disease↗
PubMed1981

[Experience in using nitroglycerin in the acute period of myocardial infarct].

To treat the left ventricular insufficiency, complicating myocardial infarction, and to limit the area of the ischemic damage of myocardium the authors used nitroglycerin solution. It is established that the nitroglycerin injection stops effectively the acute left ventricular insufficiency in myocardial infarction. Results of investigations show the decrease of the ischemic zone of the damaged myocardium in the acute period of infarction under the influence of nitroglycerin. It is concluded that intravenous drop administration of nitroglycerin is rational, under thorough control of the arterial pressure, the central venous pressure and intracardiac haemodynamics.

Aged↗
PubMed1979

[State of microcirculation in various zones of the heart in myocardial infarct complicated by congestive circulatory insufficiency].

A definite correlative connection has been revealed between the clinical course of myocardial infarction, the extent of affection of the heart muscle, the severity of the atherosclerotic process in the coronary arteries, and the condition of microcirculation in different zones of the heart. The severest affections of the heart muscle, stenosing coronarosclerosis and disorders of microcirculation in different zones of the heart were encountered in patients with myocardial infarction marked by a recurrent course and complicated by cardiogenic shock or congestive circulatory insufficiency. It is shown that the character of changes in microcirculation determines to a great measure the later condition of the structure and function of the myocardial muscle cell in areas near and remote from the infarction.

Adult↗
PubMed1979

[State of the myocardial contractile structures in different areas of the heart in myocardial infarct complicated by cardiogenic shock and congestive circulatory failure].

In myocardial infarction, destructive changes develop in the contractile elements of the heart muscle in the peri-infarction zones. The degree and extent of the myofibril involvement depend on the clinical course of myocardial infarction, the drug therapy applied, and the distance from the focus of necrosis. The most marked destructive changes were in the prenecrotic zone of the myocardium in individuals with cardiogenic shock or severe congestive cardiac failure with clinical symptoms of glycoside intoxication. Gross focal contractures of myofibrils were found, which subsequently underwent fibrinoid necrosis. There were also areas of myofibril relaxation with dissociation of the actin fibers and destruction of the z-disks. The destructive changes in the myofibrils are due to a great extent to the effect of catecholamines, myocardial hypoxia, and glycoside intoxication. The disturbed orientation of the myofibril bundles in patients with recurrent myocardial infarction may play an essential role in the decrease of the myocardial contractile function and the development of extrasystolic arrhythmias.

Aged↗