PubMed Health⌕ Search

Biomedical subjects

V K Panday

Publications and source records attributed to V K Panday.

10 recordsLinked to original sources
PubMed1986

The distribution of mercury in the Indian population.

Data have been obtained for the distribution of mercury in a non-occupationally exposed Indian adult group and compared with data available from other regions. The biological elimination half time for mercury of 33 days obtained here is in good agreement with the corresponding value for inorganic mercury compounds. The present work indicates that the relationship between dietary intake and blood concentration is only meaningful when long-term blood concentrations are measured.

Air Pollutants↗
PubMed1986

A geochemical basis for endomyocardial fibrosis.

In a search for geochemical factors that could play a role in the pathogenesis of tropical endomyocardial fibrosis, endomyocardial tissue samples obtained from patients at necropsy or operation were analysed for major elements present in laterite and monazite, which are important soil constituents of Kerala State of India. Atomic absorption spectrophotometry was used for detecting iron, silicon, aluminium, zinc, magnesium, calcium, sodium, potassium, and manganese and neutron activation analysis for thorium. Compared with control samples from victims of fatal accidents, an excess of thorium, sodium, and calcium and a deficiency of magnesium were present in samples from patients. It has been shown earlier that the staple diets of people in Kerala have high concentrations of thorium, and these data show that thorium can become concentrated in cardiac tissues. It is speculated that thorium excess in conjunction with magnesium deficiency may play a role in the causation of tropical endomyocardial fibrosis.

Endomyocardial Fibrosis↗
PubMed1985

Major metals in human cancer: calcium, magnesium, sodium and potassium.

Major elements calcium, magnesium, sodium and potassium in normal and neoplastic tissues were determined by atomic absorption spectrophotometry. Samples of neoplastic tissues were taken from surgically resected materials from different regions; oral, respiratory, gastro-intestinal, breast, reproductive regions and bone marrow and diverse types of neoplasms. Samples from areas which, on gross examination, looked normal were designated as uninvolved and were also analysed together with controls from normal Indian subjects. In neoplastic tissues concentrations of magnesium, sodium and potassium were found to be enhanced, while variability was noted for the distribution of calcium in the normal and malignant state.

Calcium↗
PubMed1984

Transition metals in human cancer II.

Many of the trace metals are associated with enzymes involved in vital physiological roles. It would therefore seem reasonable to expect alterations in the levels of certain elements to be associated with cancer. Secondly, their levels would indicate whether or not they have a direct influence on the proton spin-lattice relaxation time (T1), as determined by pulsed nuclear magnetic resonance spectrometry (NMR). The results obtained on leukaemic bone marrow and oesophageal cancer were reported earlier. In the present work is reported the data obtained for the levels of the transition elements Fe, Zn, Mn and Cu in human cancers of other regions of the body. The role of trace metals has been discussed from the point of view both of their value as markers of malignancy, and of the elevation of proton spin-lattice relaxation times.

Copper↗
PubMed1983

Nutritional status and the serum levels of Mg, Ca, Zn and Cu.

Serum Mg, Ca, Zn and Cu levels of 65 Indian children aged 5 months to 3 y 7 months, living in Bombay city, were estimated by atomic absorption spectrometry. Twenty-five well nourished controls exhibited the following serum levels: Mg 2.5 +/- 0.3 mg%, Ca 9.7 +/- 0.6 mg%, Zn 103.2 +/- 9.7 micrograms % and Cu 148.7 +/- 26 micrograms %. The remaining 40 patients were divided into four categories depending on the status of their nutrition; Group I was minimally undernourished, whereas Group IV was the worst effected. Group I (n = 6) had serum values of 2.5 +/- 0.2 mg% Mg, 8.9 +/- 0.6 mg% Ca, 85 +/- 18 micrograms % Zn and 108 +/- 25.8 micrograms % Cu. Group II (n = 20) levels were 2.2 +/- 0.3 mg% Mg, 8.3 +/- 0.9 mg% Ca, 82.6 +/- 16.5 micrograms %, Zn and 89.2 +/- 27.6 micrograms % Cu. Group III (n = 9) were 2.1 +/- 0.3 mg% Mg, 8.3 +/- 0.8 mg% Ca, 88.3 +/- 22.6 micrograms % Zn and 93 +/- 26.9 micrograms % Cu, whereas the most severely undernourished (Group IV) children had serum levels of 2.2 +/- 0.4 mg% Mg, 7.6 +/- 0.8 mg% Ca, 78.4 +/- 15.7 micrograms % Zn and 62.8 +/- 17.5 micrograms % Cu.

Calcium↗