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Biomedical subjects

V K Pillay

Publications and source records attributed to V K Pillay.

At least 19 recordsLinked to original sources
PubMed1992

Orthopaedic surgery.

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History, 20th Century↗
PubMed1980

The coraco-clavicular joint.

The present study shows that the coraco-clavicular joint should be recognised as a normal human joint that is present in a large number of people of all races. Its presence does not confer any overt advantage but neither does it give rise to any trouble. It is possibly an evolutionary joint that has arisen from the approximation of the clavicle to the coracoid and new conditions of use in man where complex movements are possible at the shoulder. The genetic basis for this joint has been elucidated and it is inherited in a simple Mendelian fashion.

Clavicle↗
PubMed1977

Medical writing.

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Documentation↗
PubMed1976

Modification of mild proteinuria by postural and other mechanisms affecting haemodynamics.

Changes in urinary protein excretion induced by standing or by the application of venous tourniquets to the thighs while the patient is in the supine position were studied in patients with mild proteinuria and compared with the changes that occur in severe proteinuria (greater than 1 mg/min). Protein excretion decreased in the majority of patients. Irrespective of the initial degree of proteinuria. The increased rate of protein excretion that occurred in a minority of patients when standing may represent a phenomenon analogous to orthostatic proteinuria.

Creatinine↗
PubMed1976

Some side-effects of alpha-methyldopa.

Three different regimens of drug treatment for hypertension were compared with regard to the development of undesirable side-effects in a group of 53 patients attending a hypertension clinic. The combination of alpha-methyldopa and chlorthalidone produced the highest incidence of side-effects. Weakness and impotence were most frequently encountered. In contrast, the combination of chlorthalidone, hydralazine and propranolol, and chlorthalidone alone, produced fewer side-effects. It is recommended that alpha-methyldopa should not be a first choice in the treatment of hypertension.

Adult↗
PubMed1976

Effect of renin on extrarenal erythropoietin production.

Extracts containing renal erythropoietic factor (REF) and others which contain renin reportedly enhance erythropoietin (Ep) titers in the plasma of hypoxic nephrectomized rats. Studies reported here were designed to elucidate the mechanism by which renin increases Ep production in the anephric rat. Injection of a renal extract containing renin significantly raised the blood pressure of anephric rats, and when it was injected just prior to exposure to hypoxia and 15 hour postnephrectomy, the resultant plasma Ep level exceeded that observed in rats exposed to the same hypoxic conditions immediately postnephrectomy. In contrast rats made hypoxic 15 hours after nephrectomy, but not given renin, had plasma Ep levels which were lower than those of anephric rats made hypoxic immediately postoperatively. When renin was injected immediately after nephrectomy or into normal rats, it failed to stimulate Ep production. When diazoxide was injected with the renin extract into hypoxic nephrectomized rats, the vasopressor effect of renin was abolished for 4 hours, and the plasma Ep levels were significantly lower than those of hypoxic nephrectomized animals injected only with renin, Injection of angiotensin II into anephric, hypoxic rats had an effect comparable to that of renin on extrarenal Ep roduction. REF was not detectable in the renin preparation. These results are best explained by the concept that renin and angiotensin increase extrarenal Ep production by causing vasoconstriction and consequently hypoxia in extrarenal sites of Ep production. Also of interest is the finding that plasma EP levels of rats, injected with renin and made hypoxic 15 hours postnephrectomy, are higher than those previously reported to occur in anephric rats.

Angiotensin II↗
PubMed1975

Relationship of posture and age to urinary protein excretion.

The influence of posture and age on urinary protein excretion was studied in 120 normal men volunteers. The supine excretion rate was less than 140 mug/min in all but two people (median value 38 mug/min) and tended to increase with age. The excretion rate decreased on quiet standing in 80% of people, which corresponded to a fall in creatinine-clearance. In the remaining 20% protein excretion increased on standing but generally remained within normal limits and was dissociated from changes in creatinine clearances. This increase was more prevalent in younger people and may represent a phenomenon analogous to orthostatic proteinuria, differing only quantitatively.

Adolescent↗
PubMed1975

Chondromalacia of the patella in Chinese. A postmortem study.

Two hundred knees of 100 Chinese cadavera were studied with reference to factors which have been implicated in the etiology of chondromalacia of the patella. The findings were as follows: chondromalacia of the patella was less common in Chinese than in Europeans, did not always start in the medial patellar facet, and showed no relationship to the presence of abnormal menisci or to the anatomical characteristics of the medial femoral condyle which have been suggested as causative factors.

Adult↗
PubMed1975

Prevalence of renal disease in asymptomatic heroin addicts.

Renal function was studied in 145 asymptomatic male heroin addicts admitted to a methadone detoxification program. The mean duration of addiction was ten years. Three patients had protein excretion greater than 150 mg/24 hr; in one of these, membranous glomerulonephritis was found. All except one had normal creatinine clearance. Hypertension was present in 2.7%. This study does not support the concept that heroin addiction is associated with a high prevalence of renal disease.

Chicago↗