In the present study 60 males and 18 females were monitored during an 18- to 20-month training period, during which the training distance was gradually increased. The training period was divided into three periods of 6, 5, and 7 months, respectively. The first, second, and third periods were concluded with a 15-, 25-, and 42-km road race, respectively. The competitive distance always exceeded the maximal distance covered in any previous training session. The effect of training was investigated for erythrocyte count, hematocrit (Ht), hemoglobin (Hb), mean cell volume (MCV), mean cell hemoglobin (MCH), mean cellular hemoglobin content (MCHC), the red cell distribution width (RDW), and ferritin content. The measuring points were the start of the study (used as a reference value) and 1 week before and 1 week after the three contests (15, 25, and 42 km). The results of all measuring points were compared transversely and longitudinally. We found a significant decrease of plasma ferritin content in the first period of the study which further remained constant. Also, other red cell parameters were decreased but remained within the normal range. During the whole training period larger intraindividual variations for most of the red cell parameters were observed compared with non-endurance-trained people.

Adaptation, Physiological↗

PubMed1989

White cell system changes associated with a training period of 18-20 months: a transverse and a longitudinal approach.

In the present study 60 males and 18 females were monitored during an 18- to 20-month training period, during which the training distance was gradually increased. The training period was divided into three periods of 6, 5, and 7 months, respectively. The first, second, and third periods were concluded with a 15-, 25-, and 42-km road race, respectively. The competitive distance always exceeded the maximal distance covered in any previous training session. The effect of training was investigated for the number of leukocytes, number of the subpopulations, and the percentage of white cells with a higher peroxidase activity (HPX cells). The measuring points were the start of the study (used as a reference value) and 1 week before and 1 week after three contests (15, 25, and 42 km). The results of all measuring points were compared transversely and longitudinally. Transversely the leukocytes hardly changed in the course of the study both in males and females, except a decrease of HPX cells. Longitudinally it appeared that Nvar and CVp90 of the numbers of leukocytes could not be calculated in males or in females. These findings suggest that a homogeneous population of leukocytes developed with respect to number and age.

Adaptation, Biological↗

PubMed1989

Platelet system changes associated with a training period of 18-20 months: a transverse and a longitudinal approach.

The effect of training for a 42-km run was investigated for the platelet count, the platelet distribution width (PDW), the mean platelet volume (MPV), and the plateletcrit (PCT). The measuring points were the start and 1 week before and 1 week after each contest (15, 25, and 42 km). For the starting position we reassessed the reference value for each platelet parameter. The results of all measuring points were compared transversely and longitudinally. As a result of the transverse approach, we found a significant decrease of the platelet count and of the MPV, which means a decrease of total thrombocytic clotting capacity with increasing training intensity. The longitudinal approach showed large intraindividual variations for all platelet parameters during the course of the study, expressed as high values for Nvar and CVp90.

Adult↗

PubMed1986

[Circulating interferon in patients with systemic lupus erythematosus. A prospective study].

The serum levels of interferon (IFN) were measured in 31 patients with systemic lupus erythematosus (SLE). Among the 31 patients, 8 (25%) showed IFN in the sera: in 4 patients IFN titers of 16 U/ml, and in the other 4 patients titers of greater than or equal to 32 U/ml became detectable. Whereas antibodies to native DNA (nDNA) were present in 6 of the 8 IFN positive patients, anti-nDNA antibodies were only positive in 6 of the 23 IFN negative individuals (p less than 0.002). Eight months after the first search for IFN in the patients' sera, 6 of the 8 IFN positive patients showed reduced IFN serum levels and one each had an increased or stable IFN titer. A good correlation between IFN titers and both the anti-nDNA antibody titers and the disease activity was observed. However, there were patients with active disease, high anti-nDNA titers but no IFN in the serum.

Adult↗

PubMed1972

[Fat and uric acid metabolism during acute effect of oxylitol].

Explore the source record for details and available documents.

Acetoacetates↗

PubMed1972

[Serum concentrations of various lipids and uric acid during a two-week xylitol administration].

Explore the source record for details and available documents.

Acetoacetates↗

PubMedDate not supplied

Diagnostic value of signs and symptoms associated with peripheral arterial occlusive disease seen in general practice: a multivariable approach.

OBJECTIVES: To assess the diagnostic values of single and combined data from the history, physical examination, and medical record with regard to peripheral arterial occlusive disease (PAOD) in patients with leg complaints; to construct a multivariable model for the clinical diagnosis of PAOD by primary care physicians. SETTING: 18 general practice centers in The Netherlands. DESIGN: Cross-sectional comparison of signs, symptoms, and data from the medical record with the independently assessed ankle-brachial systolic pressure index (ABPI; cutoff point < 0.90); analysis: bivariate, multiple logistic regression (MLR). POPULATION: 2,455 individuals with leg complaints, aged 40.7-78.4 years; ABPI < 0.90 present in 9.2% of legs (11.7% of individuals). OUTCOME MEASURES: Clinical variables: sensitivity, specificity, positive and negative predictive values (PV+, PV-), diagnostic odds ratio (OR); models: likelihood ratio test, area under the receiver operating characteristic curve (AUC). RESULTS: Bivariate analysis: highest sensitivity: age more than 60 years (77.3%); highest specificity: wounds or sores on toes and foot (99.7%); highest PV+: typical intermittent claudication (IC) (45.0%) (abnormal foot pulses 41.3%); highest PV-: strong pulses of both foot arteries (97.7%). MRL: the best-performing model (AUC 0.89) consisted of ten clinical variables: gender (OR 1.5), age more than 60 (OR 2.2); IC (OR 3.5); palpation of the skin temperature of the feet (OR 2.5), palpation of both foot pulses [OR 16.4 (abnormal) and 7.0 (doubtful)], auscultation of the femoral artery (OR 3.5); previous diagnosis of IHD (OR 1.7) or diabetes (OR 1.6), history of smoking (OR 2.1), and elevated blood pressure (OR 1.5). The range of predicted probabilities was 0.4-98%. The Hosmer-Lemeshow goodness-of-fit test indicated good overall fit (p = 52). CONCLUSIONS: Palpation of both foot pulses is the key procedure for the clinical diagnosis of PAOD. Traditional clinical evaluation enables the general practitioner to exclude the diagnosis of PAOD in many individuals with a high degree of certainly, to establish the diagnosis in a small group of patients, and to define a limited group of patients where supplementary noninvasive testing is appropriate. The MLR model can be used as a diagnostic checklist and as a reference for the physician's clinical hypothesis.

Adult↗