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Biomedical subjects

V Keller

Publications and source records attributed to V Keller.

11 recordsLinked to original sources
PubMed2006

A practical demonstration in modelling diclofenac and propranolol river water concentrations using a GIS hydrology model in a rural UK catchment.

An existing GIS hydrology water quality model, LF2000-WQX, was applied to predict the concentrations of the pharmaceuticals diclofenac and propranalol in catchments. As a practical exercise the predominantly rural Tamar (UK) catchment was chosen. Consumption, excretion, and fate data were used to estimate the pharmaceutical input load for the model. The predicted concentrations throughout most of the catchment were 1 ng/L or less under low flow (90th percentile) conditions. However, at a few locations, downstream of small sewage treatment plants, concentrations above 25 ng/L were predicted. This exercise shows that it is relatively straightforward to predict the concentrations of new and emerging organic microcontaminants in real catchments using existing GIS hydrology water quality models. Further testing will be required to establish their accuracy.

Computer Simulation↗
PubMed2005

Estimating population served by sewage treatment works from readily available GIS data.

Environmental risk assessment of household chemicals at the catchment scale requires an estimate of the load at individual Sewage Treatment Works (STWs). This can be achieved based upon population served and market consumption data. Although the population served is difficult to obtain, this paper shows that reasonable estimates can be made using readily available spatially referenced data. A new method is developed using STW data from the Exe and the Aire and Calder catchments and validated using 193 STWs within the Environment Agency's Anglian region. The estimated populations served were compared with available estimates of Population Equivalents (PEs). The population estimates were broadly similar to PEs for small works but agreement was lower for larger plants. The discrepancy for larger works is consistent with trade influent inclusion in the PE. The method is suitable for application to both rural areas and large urbanised areas, although the interpretation of corroborating data becomes increasingly difficult in very large urban areas serving more than one STW.

Geographic Information Systems↗
PubMed2005

Risk assessment of "down-the-drain" chemicals: search for a suitable model.

Legal and regulatory authorities around the world generally require that risk assessments are undertaken for the licensing of new and existing substances that present high risk to the environment or the human health. This applies to 'down-the-drain' chemicals that are usually found in household products, such as detergents, that are mainly discharged into rivers via sewer systems. However, the data available for these chemicals is often limited due to cost constraints: in particular, concentration time series for works effluent are generally unavailable, even load data for specific works is often scarce. Although a wide range of models are available, there is a general lack of knowledge on their suitability to model the fate of down-the-drain chemicals at the catchment scale. Several models are presented in this review. The models selected are: the Mackay models, EUSES, Mike 11, QUAL2E, TOMCAT and GREAT-ER. Various applications of these models were investigated to investigate their strength and weaknesses. It appears that, where the availability of data is limited, multimedia fate models such as the Mackay models and EUSES may best be applied to estimate the global risk within each media. However, for site-specific risk assessment the GREAT-ER in-stream water quality model was considered to be more appropriate for modelling down-the-drain chemicals, because it accounts for both spatial and temporal variability, while its data requirements are lower than for models such as Mike 11 and QUAL2E.

Environment↗
PubMed2000

Communicate with CARE.

Explore the source record for details and available documents.

Attitude of Health Personnel↗
PubMed1994

Analysis of immunocytochemical staining patterns in the antennal system of Drosophila melanogaster.

By immunizing mice with homogenized brains, heads, or a mixture of heads and antennae of D. melanogaster, we obtained six monoclonal antibodies (mabs) that bind to the olfactory system of Drosophila with various degrees of specificity. They can be divided into three groups with respect to their staining pattern: (1) The antibodies ca51/2, na21/2, and nb230 label both in the third (olfactory) antennal segment and in the visual ganglia. All of them bind to antennal structures that can be correlated with basiconic sensilla. The antibody ca51/2 labels sensory neurons of these sensilla. In the antenna of the lozenge mutant, which lacks basiconic sensilla, no labeling is present. In Western blots ca51/2 recognizes in the antenna an antigen of 43.5 kDa, which is expressed in the antenna only in the presence of basiconic sensilla. The antibody na21/2 binds to basiconic and coeloconic sensilla, most likely to the apical part of sheath cells. In immunoblots it recognizes in the antenna two antigens of 42.2 kDa and 46.7 kDa. The latter appears to be correlated in the antenna with the presence of basiconic sensilla. (2) The staining pattern of antibody nc10 is associated with the sheath cells of basiconic and coeloconic sensilla. Moreover, nc10 binds to a subset of glomeruli in the antennal lobe. (3) The staining pattern of the antibodies VG2 and I24B5 is restricted to the antenna. I24B5 recognizes coeloconic sensilla and VG2 recognizes both coeloconic and basiconic sensilla. Staining patterns in both cases include sheath cells.

Animals↗
PubMed1994

[Conconi tests in children].

From 1990 to 1992 we carried out 158 Conconi-Tests on children aged from 7 to 15. Of these tests 128 were carried out on the 400 m-track, and further 30 were Conconi-Intervall-Tests (Probst-Test). The testing was done on the members of the Swiss Figure-Skating Team, on the best runners of the Volksbank Grand Prix St. Gallen 1991/92 and on the youngest girls and boys of the Athletic Club Brühl St. Gallen. 89 tests were performed on girls and 69 tests on boys. In 84% of all cases (133 tests) the results were open to unambiguous interpretation, and were determined by the anaerobic threshold, 14% (22 tests), however, could not be clearly interpreted or had to be done again, and in 2% of all cases (3 tests) the results delivered no analysable information. In the results we only considered the 133 tests where clear interpretation was possible (114 from 128 Conconi-Tests, i.e. 89%, and 19 from 30 Probst-Tests, i.e. 63%). Thus we achieved the first aim of our research, which was to investigate the feasibility of carrying out Conconi-Tests on children and analysing the subsequent results thereof (with very interesting threshold results). From this, it is hoped, that norm data can be established, on which the anaerobic threshold and the threshold pulse of children active in sports can be based. At this point it must be stated that the classical Conconi-Test was found to deliver data easily and clearly interpretable, while the Intervall-Test was less easily analyzable.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1979

[Music therapy, its indications, goals and possibilities].

After a short historical introduction the author presents an overview on the various methods used in music therapy with respect to their goals and their limits. There are quite different forms of receptive and active music therapy in individual and group therapy. Finally, the author describes the evolution of two cases of individual music therapy.

Adult↗