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Biomedical subjects

V Kentsch

Publications and source records attributed to V Kentsch.

5 recordsLinked to original sources
PubMed1981

[The risks of photochemotherapy (author's transl)].

The side effect of phototherapy with 8-methoxypsoralen was divided in short- and longterm damage. From 1969 till 1980 2 013 patients were treated. The pattern of alteration by PUVA depends on doses, continuance of therapy and type of dermatoses as psoriasis, vitiligo, mycosis fungoides, physical urticarias, chronic eczemas. The spontaneous development of tumors, the initiating or promotion of tumors by PUVA as well as a regression of tumors by PUVA has to be taken into account regarding the absolute numbers of tumors after PUVA-therapy. The risk of the PUVA-therapy depends on the doses of continuance of the treatment including the combination with other sources of radiations or natural sun-exposition. The possibilities of drug combinations to lower the total doses of light energy are discussed according the recommendation of several teams in Germany.

Chronic Disease↗
PubMed1979

Melanin granula distribution and phagocytosis in psoriasis vulgaris after PUVA therapy.

Melanin-containing basal cells of the epidermis, melanin-containing macrophages, mast cells, eosinophilic granulocytes and plasma cells were quantitatively investigated with the purpose of gaining an understanding of the quantitative changes in these cell systems under PUVA therapy. This patients have been exposed to solar radiation some weeks or months before the begin of the PUVA-treatment. Different dying-processes were used to investigate biopsy samples of psoriatically healthy and psoriatically affected skin, from 28 patients before, and 39 patients after PUVA therapy, using a 2 d micrometer with a field of view of 0.1 mm2. Altogether more than 9,000 fields of view have been analysed. The average radiation amount was 12 irradiations with an average total energy of 21.5 J/cm2. It was found that the count of granula-containing basal layer cells decreases in the psoriatic "healthy" region due to pigment incontinence and increase in the psoriatically affected region. The subepidermal melanin-containing phagocytes increase in both regions to a similar extent. In the case of the mast cells there was no trend to degranulation. The count of eosinophilic granulocytes and plasma cells was unchanged.

Eosinophils↗
PubMed1976

Simplification of local therapy of psoriasis with 8-methoxypsoralen. Methods and initial results.

Local 8-methoxypsoralen black-light treatment was carried out on sixty-two patients. For the first time, oil was employed as a preparation base in order to increase the transparency and so the effectiveness of irradiation. Also the need for a descaling pretreatment was avoided. In investigations still being carried out, 27.5% patients showed very good improvement, 48-4% good and 24-2% unsatisfactory results of treatment. In many cases, less than fifteen irradiation sessions were necessary for clinical healing. However, to obtain a uniform pigmentation, additional irradiation proved necessary.

Erythema↗