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Biomedical subjects

V Kesić

Publications and source records attributed to V Kesić.

At least 19 recordsLinked to original sources
PubMed1993

[Duodenal polyps of gastric origin].

Recently, thanks to the collected knowledge and increased diagnostic abilities we more often meet the diseases that have been considered very seldom. Beside that, we form the new assumptions that must be proved. Today, more often we meet gastric mucosa in duodenum. That according to some researchers, introduces a real possibility for appearance of the polyps, ulcers or cancer on gastric substratum. In the subject patient the two polyps of the gastric origin were found in a duodenum. That could support the assumption that ectopic gastric mucosa presents one of the real possibilities for appearance of polyps, ulcers and cancer.

Aged↗
PubMed1990

T lymphocytes in non-malignant, pre-malignant and malignant changes of the cervix.

T lymphocytes play an important role in the immune response to both neoplasia and viral infection. Normally about 60% of T lymphocytes in the peripheral blood are T4 lymphocytes, while 20-30% are T8 ones. The T4/T8 ratio is usually 2:1. When this ratio is inverted the most significant changes occur. The aim of our study was to examine the T4/T8 lymphocyte ratio in the peripheral blood of patients with histologically confirmed non-malignant and premalignant changes of the cervix and to compare it both with the ratio in patients with squamocellular carcinoma of the cervix and those without any cytological or colposcopical cervical abnormality. The study group consisted of 118 patients, 17 of them had leukokeratosis of the cervical epithelium, 20 had cervical intraepithelial neoplasia (CIN) and 42 patients had cervical cancer, 39 patients had normal cervical findings and comprised the control group. Peripheral blood lymphocytes were examined by indirect immunoperoxidase technique, using OKT 4 and OKT 8 monoclonal antibodies. The average T4/T8 lymphocyte ratio in the peripheral blood of patients with leukokeratosis was 1.55, and in those with CIN 1.19. In patients with cancer the ratio was 1.34. The differences was not statistically significant. The control group had an average T4/T8 ratio of 2.31 which was significantly different compared to the results of the other groups. The value of these and similar results obtained by other authors is still uncertain. The alteration of T lymphocyte subsets may occur in the peripheral blood of patients with viral infections and some viruses are considered important in the etiology of CIN.(ABSTRACT TRUNCATED AT 250 WORDS)

Antibodies, Monoclonal↗
PubMed1988

Epidemiology of cancer of the female genital organs in Yugoslavia.

The descriptive epidemiological method was applied. In the preparation of the data, basic statistical procedures were used. Data were obtained from Slovenian Cancer Registry and Yugoslav Statistics Institute, and studied over the period from 1971 to 1985. In terms of rate of occurrence, malignant neoplasms of the female genital organs rank first in all cases of cancer, with 20.94%. Uterine cervix and corpus and ovary, are always in the ten leading primary cancer sites. Malignant neoplasms of the female genital organs comprise about 2% of all causes of death in females and just over 15% of all deaths from cancer. Cervical cancer has an average incidence rate of 18.56, while mortality rate is 4.67 per 100,000 women. Both incidence and mortality decreased throughout the investigated period. Other malignant neoplasms of the uterus appear in 15.45 cases per 100,000 and this rate shows a slightly increasing trend. However, the mortality rate is 3.77 and this shows a distinct decrease, in all parts of the country. The average incidence rate for cancer of the ovary is 12.61, decreasing slowly. Malignant neoplasms of the ovary have the mortality rate of 3.94, which has been constantly rising. Malignant neoplasms of the other genital organs have the average incidence rate of 3.15 and mortality rate of 0.95. These rates remain stable over the period from 1971 to 1985.

Adolescent↗
PubMed1985

Genetic factors and fetal growth sex constitution and birthweight in twins.

Fetal growth is considered a multifactorially-influenced characteristic. Genetic factors were found to play the main role in fetal growth determination, and it is the polygenic inheritance. The paper reviews the birthweights of 360 unlike-sexed two-egg twins, born at the Clinic of Gynecology and Obstetrics, Faculty of Medicine in Beograd, from January 1, 1970 through June 30, 1984. The mean birthweight differences between the male (2954.94 +/- 704.28 g) and female (2313.19 +/- 651.32 g) fetuses, amounted to 141.75 g. The difference is highly significant (P less than 0.01); variation coefficient shows that the examined groups were homogenous (VC was below 30%). The results were discussed from the genetic point of view, and particularly from the point of view of sex constitution, with special respect to the effect of Y chromosome on fetal growth. It has been known that human somatic development, body weight, bone maturation and teeth development are influenced by variety of factors. In addition to nutritional and other factors of the external environment, genetic and humoral factors are leading. The fact that fetuses with XY male constitution are heavier at birth than female fetuses with XX constitution, made us consider the correlation between genotype-phenotype, and the mentioned characteristics. This study was aimed at finding out the role of genetic factors in fetal growth, with respect to sex constitution, particularly to chromosome effect on fetal growth in unlike-sexed two-egg twins.

Birth Weight↗
PubMedDate not supplied

[Chronic gastritis].

Explore the source record for details and available documents.

Chronic Disease↗
PubMedDate not supplied

[Correlation of sonographic and patho-anatomic findings in myomatous changes in the uterus].

In spite of the fact that ultrasound is an accessory diagnostic measure in gynaecology, added to clinical examination, it can help in a more accurate diagnosis and better preparation for surgery. The comparison of data obtained by ultrasonic and macroscopic measurements of uterine leiomyoma in 130 patients did not reveal a statistically significant difference between the two methods. The mean size of all measured leiomyomas was 61.47 mm in longitudinal diameter, 53.00 mm in anteroposterior and 53.95 mm in transversal. Measured by ultrasound the mean dimensions of the same diameters were 62.29 mm, 56.91 mm and 55.11 mm respectively. Differences in the mean values of all measured diameters obtained in some cases can be explained by subjective elements in the use of ultrasound, the examiners experience and postoperative reduction of the removed organ volume, as well as by technical factors which may influence the ultrasonic image. Thus, the accuracy of ultrasonic measurement completes the knowledge about the size of the pelvic mass; it is helpful in preparation for surgery, and decreases the possibility of unexpected situations during the surgery.

Female↗
PubMedDate not supplied

[T lymphocytes, non-malignant and premalignant changes in the planocellular epithelium of the uterine cervix].

T lymphocytes play an important role in the immune response to both neoplasia and viral infection. Normally, about 60% of T lymphocytes in the peripheral blood are T4 (helper) lymphocytes, while 20-30% are T8(suppressor) lymphocytes. When this ratio is inverted, most significant changes occur. The aim of the study was to examine the T4/T8 lymphocyte ratio in the peripheral blood of patients with nonmalignant and premalignant changes of the cervical epithelium and to compare it with that in patients without any cytological or colposcopical cervical abnormality. The results show a significant decrease of the T4/T8 lymphocyte ratio in the peripheral blood of patients with leukokeratosis (1.55) and especially of those with cervical intraepithelial neoplasia (1.19), compared with the results of the control group (2.31). These findings, as well as the knowledge of the importance of immune response in the control of the onset of malignancy, that the determination of T4/T8 lymphocyte ratio might be helpful in the prediction of the degree of premalignant cervical chance and indicate patient's follow-up.

Cervix Uteri↗
PubMedDate not supplied

[Smoking and nonmalignant changes in the uterine cervix].

The evidence of the association between smoking and cervical dysplasias has been established by several reports. It has been suggested that smoking might depress the immune mechanism and allow a sexually transmitted infective agent to result in an abnormal cellular development, leading to the onset of dysplasia. It, was also established that some chemical products of smoking could be selectively deposited in gynaecological tissues. The aim of this study was to examine the frequency of smoking habits in patients with non-malignant cervical changes and to compare it to the one in patients without cytological or colposcopical cervical abnormalities. The study group consisted of 63 patients with historically confirmed non-malignant cervical changes: 6 patients with cervicitis, 12 with leukokeratosis of the cervical epithelium, 13 with mild dysplasia, 21 with moderate dysplasia and 11 patients with sever dysplasia. 68 patients were without cervical changes and made the control group. The percentage of smokers among the patients with cervical changes (53.97%) statistically significantly differs from the results of the control group (32.35%). This percentage is increasing with the severity of cervical change. Testing for a dose-response relationship reveals no difference between the light and heavy smokers. An increased risk for development of cervical changes with increasing duration of smoking could not be established. The results are in agreement with the opinions that smoking is associated with an increased risk for development of cervical dysplasia which is considered to be a precursor lesion of cancer of the cervix. Although it could not be established by our analysis, it is thought that this risk increases with the increased frequency and longer duration of smoking.

Adult↗
PubMedDate not supplied

[Cervicography--a useful method for the early detection of changes in the uterine cervix].

Cervicographic findings were analysed in 156 patients of whom 71 had previously been found to have cervical changes (group I) and 85 were regularly examined within the periodic systematic examination programme (group II). In group I there were 15.5% negative cervicographic findings, 80.3% suspect, and 4.2% technically inadequate. Out of suspect findings, carcinoma in situ or invasive carcinoma were detected in 54.4%, of which 9.7% were cytologically false negative. In group II, in 69.4% of cases, some colposcopic changes (non-malignant) were observed, while in 3 out of 26 colposcopically normal findings, there were some changes in the cervicogram.

Colposcopes↗
PubMedDate not supplied

[Primary ovarian cancer].

Out of 108 patients treated for primary ovarian cancer from 1984 to 1986, 76% suggested adnexal changes, while malignancy was suspected only in 35% of them. The first symptoms appeared in 51.8% of patients up to three months before the establishment of the diagnosis. In the two thirds of them the disease was in the III or IV stage. Histologically, epithelial tumours were most frequent (86.1%), mostly (51.6%) moderately differentiated. Surgery ranged from hysterectomy with adnexectomy and omentectomy (58.3%) to explorative laparotomy with biopsy. Later intervention included chemotherapy in 62%, chemotherapy and radiotherapy in 15.7%, and radiotherapy alone in 14.8% of patients. Too short a time has elapsed since the treatment started to predict a 5-year survival, but the 2-year survival for all patients amounts to 38.9%.

Adolescent↗