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Biomedical subjects

V Khurana

Publications and source records attributed to V Khurana.

At least 19 recordsLinked to original sources
PubMed2000

Cancer screening in the elderly population.

This article reviews the current state of knowledge regarding cancer screening in the geriatric population. Care of the elderly requires knowledge of underlying physiologic changes, comorbidities, quality-of-life factors, and life expectancies. There is always the danger that ageism may prevent elderly cancer patients from receiving the proper treatment. On the other hand, overzealous treatment can lead to adverse results if elderly patients are not properly targeted based on current evidence of the benefits and risks of specific screening practices.

Age Factors↗
PubMed1999

Prevalence of chronic inflammatory demyelinating polyneuropathy in New South Wales, Australia.

A prevalence study of chronic inflammatory demyelinating polyneuropathy (CIDP) was performed in New South Wales (NSW), Australia, with a prevalence day of August 6, 1996, which coincided with a national census. The population of NSW was 5,995,544, and the crude prevalence of CIDP was 1.9 per 100,000 population. It was higher in male patients than in female patients, and the age-specific prevalence reached a maximum of 6.7 per 100,000 population in the 70- to 79-year-old age group. The prevalence in the city of Newcastle, with a population of 448,663, was 2.0 per 100,000 population and is representative of the whole of NSW. The estimated crude annual incidence was 0.15 per 100,000 population. The mean age of onset was 47.6 years (median, 53.5 years), 51% of patients had a relapsing-remitting course, the mean duration on prevalence day was 7.1 years (median, 5 years), and 87% of patients were able to walk without walking aids or other assistance.

Adolescent↗
PubMed1999

Lead poisoning from a retained bullet: a case report and review.

A 47-year-old man with a prior gunshot wound presented with arthritis, constipation, abdominal pain, and weight loss. Arthrocentesis did not reveal the cause of the arthritic complaints, but lead poisoning was suspected and confirmed. We present this case along with a short review of the literature pertaining to this often overlooked and reversible cause of lead poisoning.

Chelating Agents↗
PubMed1998

Probability of quantal secretion and the mobilization of vesicles at the active zones of endplates.

A vesicle mobilization model is developed for active zones of motor-nerve terminals. In the model, vesicles from a storage pool are recruited to an available pool where they are docked at the active zone, the latter pool being replenished by endocytosis. The predictions of this model are then compared with experimental results on these active zones. If a styryl dye (FM1-43) is used to stain all of the vesicles at motor-nerve terminals then the stores of vesicles associated with different active zones are shown to vary considerably in size. Under the assumption that the available pool size is proportional to the storage pool size, the mobilization model shows that the extent of destaining of these stores during a particular period of stimulation is proportional to the size of the storage pool, this size being indicated by the initial staining. This is not so under the alternative assumption that the available pool size does not vary proportionally with store size. If the two pools are proportional then the number of quanta released from the available pool is proportional to the storage pool size. Experimental results indicate that there is a linear relationship between destaining and staining, as well as between quantal release and staining at different sites along motor-nerve terminals, thus favouring the hypothesis that available pool size (or the size of the active zone) and store size are proportional. Given that there are very different store sizes along the length of motor-nerve terminals, this analysis provides further evidence for the non-uniform probability of quantal secretion at different active zones within a single motor-nerve terminal.

Amphibians↗
PubMed1998

Adult-onset Still's disease associated with G6PD deficiency: a case report and literature review.

A 37-year-old man presented with symptoms consistent with adult-onset Still's disease. Fever and leukocytosis were prominent, and the patient was started on high-dose aspirin for possible acute rheumatic fever. He developed severe anemia as a result of glucose-6-phosphate dehydrogenase deficiency. His treatment was changed to naproxen, and he recovered with restoration of his hematologic parameters. Although Still's disease is frequently accompanied by mild-to-moderate anemia, the development of severe anemia should raise the possibilities of hemolysis secondary to glucose-6-phosphate dehydrogenase deficiency.

Adult↗
PubMed1994

The effect of midbrain collicular knife cuts on audiogenic seizure severity in the genetically epilepsy-prone rat.

Previous studies showed that the inferior colliculus (IC) and the pontine reticular nucleus (RPO) are involved in the initiation and propagation of seizure activity in genetically epilepsy-prone rats (GEPR-9s), respectively. Bilateral knife cuts in the coronal plane were made in the midbrain to determine what effect the disruption of efferent fibers of the IC would have on seizure activity. In addition, some lesions were injected with horseradish peroxidase (HRP) to trace the interrupted fibers and identify the neurons of origin. Consistent with previous results, lesions that involved the central nucleus of the IC or the lateral lemniscus blocked audiogenic seizures. Seizures were also blocked with lesions located between the external and central nuclei of the IC. In contrast, lesions located between the IC and superior colliculus and those within the superior colliculus reduced the audiogenic response score, but did not completely block audiogenic seizures. In the cases with intercollicular lesions, HRP-labeled axons were observed to arise from neurons in both the external nucleus and dorsal cortex of the IC, but not the central nucleus, and they entered the deep layers of the superior colliculus. These results indicate that the projection from the central nucleus to the external nucleus of the IC is important for the propagation of seizure activity in GEPR-9s. Also, these data show that projections from the IC to the superior colliculus play a role in seizure propagation.(ABSTRACT TRUNCATED AT 250 WORDS)

Acoustic Stimulation↗