[A screening test to detect phenylketonuria and a semiquantitative determination of blood plasma phenylalanine by thin layer chromatography].
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Biomedical subjects
Publications and source records attributed to V Klingmüller.
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The article reports on the case history of a 8 month old baby who fell ill of a ileocolic intussusception. The barium enema demonstrated the typical cupping in the head of the barium. The successful reposition by hydrostatic pressure was manifest by barium reflux in the small intestine.
For revascularisation of femoral head with osteonecrosis and pseudarthrosis of the femoral neck 68 femoral head were treated with a pedicled bonegraft. Therefore were taken the medial bonegraft (A. circumflexa ilium profunda) and the lateral bonegraft, based on the deep branches of the superior gluteal vessels. On the basis of postexamination it is reported about the first 35 patients, who were treated with a medial autological pedicled bonegraft. Prae- and postoperative each of them was clinical, radiological and angiological examinated. Because of this operation in 78.8% the clinical picture, existing about pain and the ability to walk and move, could be improved.
23 hip joints with hip head necrosis in 22 patients were provided with a pedicle bone-graft perfused by the art. circumflexa ilium profunda. I two cases it was necessary to remove the bone-graft contralaterally because bone had already been removed from the side with the necrosis at an earlier date. In these cases the arterio-venous bundle of vessels of the autologous heterotope transplant was connected through microanastomosis with the arteria and vena circumflexa femoris lateralis. In addition to the usual clinical follow-up the method of superselective angiography was also applied to make possible direct perfusion control of the implanted bone-graft in the operated patients. In 18 of the 23 pedicle autologous heterotope transplants unimpeded perfusion could be shown. By introducing regional stress angiography in 7 cases it became possible to make further well-founded statements about the physiotherapeutical follow-up treatment. Electronic subtraction provides a more accurate assessment of even the minutest arteries possible.
This is a report of special operative therapy of idiopathic necrosis of the femoral head. This is based on the idea, that the necrosis of the femoral head is caused by an occlusion of the arteries of the femoral head, especially the arteria circumflexa femoris medialis. The necrotic area of the femoral head is filled up with a pedicle bone graft, which is apart from the spina iliaca and supplied from the art, circumflexa ilium profunda. From a total of 28 superselective angiographies of the arteria circumflexa femoris medialis, which where conducted preoperatively, a pathological finding was shown in 21 cases. Furthermore it is possible, to determine different courses of the art. circumflexa ilium profunda. A superselective angiography of the reset art. circumflexa ilium profunda was conducted in seven patients following the bone graft operation. These findings will be discussed. The angiographies were processed by electronic subtraction to better illustrate the state of the smallest vessels.
BACKGROUND: Date, studies on thyroid volume and urinary iodide excretion in patients with diabetes mellitus are not available. Sonographically determined parameters of the thyroid size are correlated to other anthropometrous data and the urinary iodide excretion is correlated to glucosuria, the HbA1c value and the diabetes duration. METHOD: In this prospective study we evaluated sonographically the thyroid volume in 107 patients with type I diabetes mellitus and 112 healthy children. The urinary iodide excretion was measured photometrically by using a modified ceric ion arsenious acid method for spontaneous urinary specimen and if available for the 24 h collected urin. RESULTS: The thyroid volume depended on site and age. A positive correlation of the thyroid volume and age, body weight and height, could be demonstrated. Referring to reference data a goitre prevalence of 30% in juvenile patients with diabetes mellitus type I was detected. Interestingly, juvenile type I diabetics presented with an average urinary iodide excretion of 183.0 micrograms iodide/g creatinine. Even the urinary iodide excretion of 162.5 micrograms iodide confirmed this increased level. The urinary iodide excretion in 24 hours correlated with glucosuria and the HbA1c level. The healthy children presented with an average urinary iodide excretion of 42.6 micrograms iodide/g creatinine. The mean value was clearly below the WHO recommendation of 150-300 micrograms iodide/g creatinine. Only 2.8% of the healthy children examined exceeded the lower limit of this range. CONCLUSION: In addition to the existing distinct under supply of iodide we assume an increased urinary iodide excretion in context with the osmotic diuresis in juvenile diabetics. Contrary to current opinion, that these data are correlated to the daily intake of iodide, which was calculated from urinary excretion rate, this thesis could not be affirmed for juvenile diabetics. Therefore it seems reasonable to frequently control thyroid volume and thyroid function in children and adolescents with diabetes mellitus.