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V Knotková

Publications and source records attributed to V Knotková.

At least 19 recordsLinked to original sources
PubMed1996

[Vasoactive factors in chronic glomerulonephritis].

BACKGROUND: The kidney damage in chronic glomerulonephritis develops not only as a result of causal immunopathological evens, but also due to chronic adaptation changes. The study was aimed at identification of active agents, which can serve as markers of proceeding adaptation changes and to determine, if these changes may be determined in patients undergoing the stage of remission of chronic glomerulonephritis. METHODS AND RESULTS: The authors determined renin activity, concentration of atrium natriuretic peptide and endothelin in plasma and elimination of some prostanoids in urine in 33 patients with chronic stabilized glomerulonephritis with normal glomerular filtration and with normal blood pressure and in 21 healthy subjects. Seventeen patients without proteinuria did not receive therapy, 16 patients with minute proteinuria received 100 mg of acetylosalicylic acid daily. In the untreated patients without proteinuria, the elimination of thromboxane in urine was significantly higher than in both other groups. The plasma level of atrium natriuretic peptide in all 33 patients was significantly lower than in the healthy persons. CONCLUSIONS: Based on this study the authors believe that adaptation changes proceed even in patients with chronic glomerulonephritis in clinical remission. The increased production of renal thromboxane, which can be successfully blocked by acetylosalicylic acid may be the marker of glomerular changes. A decreased level of atrium natriuretic peptide could reflect tubulointerstitial changes.

Adaptation, Physiological↗
PubMed1996

[Microalbuminuria in patients with glomerulonephritis in remission].

The authors focused their attention on residual changes in patients with glomerulonephritis who have a zero or only "physiological" proteinuria (under 0.15 g/24 hours), normal or slightly elevated s-creatinine and who do not suffer from hypertension. In these patients microalbuminuria in urine per 24 hours was assessed. Patients with albuminuria under 20 micrograms/min were included in the group with normal albuminuria (13 patients) and patients with albuminuria of more than 20 micrograms/min in the microalbuminuric group (11 patients). The two groups did not differ significantly as to age, sex, duration of the disease, maximum levels of proteinuria and s-creatinine values at the onset of the disease. S-creatinine and blood pressure values at the time of investigation were also comparable. The groups differed, however, significantly as to the period of "absolute" remission which the authors defined as the period during which proteinuria did not exceed the "physiological" limit. This period was in the normoalbuminuric group significantly longer--on average 5.1 years--while in the microalbuminuric group it was 2.1 years (difference at the 1% level of significance).

Albuminuria↗
PubMed1994

[Present possibilities of treatment of primary chronic glomerulonephritis].

The authors evaluate in a retrospective study the effect of prednisone, cyclophosphamide, small doses of acetylsalicylic acid, conventional antihypertensive drugs and ACE inhibitors on the course of primary chronic proliferative types of glomerulonephritis. The group comprised 44 patients, incl. 16 with normal blood pressure and 28 with hypertension. All were at first given prednisone and cyclophosphamide--for an average of 18 months--and the patients with systemic hypertension conventional antihypertensive drugs. At the termination of treatment proteinuria in the whole group was significantly lower, while glomerular filtration was unaltered, i.e. normal. When the results in normotonic and hypertonic patients were evaluated separately, it was obvious that normotonic patients have a significantly lower proteinuria and a glomerular filtration significantly higher than hypertonic patients. After termination of immunosuppression the authors started to administer to all patients acetylsalicylic acid (1/4 tablet Anopyrin in 24 hours) and in hypertensive patients the conventional antihypertensive drugs were replaced by ACE inhibitors, combined in some with Ca channel blockers. Antiaggregation therapy persists now for more than three years, treatment with ACE inhibitors for more than two years. The results at the end of the investigation indicate that there is no significant difference between normotonic and hypertonic subjects. All have proteinuria lower than 2.0 g/24 hours, stabilized glomerular filtration and after 15 years of glomerulonephritis none of the patients suffers from chronic renal failure. The authors assume that combined immunosuppression, antiaggregation therapy and treatment of hypertension with ACE inhibitors can contribute to the stabilization of chronic glomerulonephritis.

Angiotensin-Converting Enzyme Inhibitors↗
PubMed1994

[Treatment of macroscopic hematuria complicating renal biopsy by embolization of a branch of the renal artery].

The authors describe a case of recurrent macroscopic haematuria which developed after renal biopsy in a young patient with IgA dominant focal and segmental mesangioproliferative glomerulonephritis. As conservative treatment was not successful, renal angiography was performed which revealed a false aneurysm of the segmental branch of the renal artery at the site of the assumed puncture. After selective embolization with gelaspon granules macroscopic haematuria receded quickly.

Adolescent↗
PubMed1993

[Primary chronic glomerulonephritis with nephrotic syndrome. Treatment with prednisone and cyclophosphamide].

The authors present their long standing experience with immunosuppressive treatment of patients with nephrotic syndrome associated with primary chronic membranous, mesangioproliferative and mesangiocapillary glomerulonephritis. Of a total of 127 patients 99 were treated with prednisone and cyclophosphamide and 28 with cyclophosphamide only. Clinical remission developed in 89 patients (70%). Remissions developed independently on morphological findings and initial proteinuria, but more frequently in patients with a still normal glomerular filtration. In combined immunosuppression 77% of the treated patients developed remission, while only 48% treated with cyclophosphamide alone. 88% of the patients survive an average period of 10 years. From the investigation it is apparent that long-term and early combined immunosuppression has a favourable impact on the course of primary chronic glomerulonephritis with nephrotic syndrome.

Adult↗
PubMed1993

[Essential mixed cryoglobulinemia and the kidneys].

The authors describe their experience with the treatment of nine patients where "essential" mixed cryoglobulinaemia was diagnosed. In addition to extrarenal symptoms all suffered from proliferative glomerulonephritis, most frequently mesangiocapillary. The latter was manifested in most instances during the first examination by nephrotic syndrome and reduced glomerular filtration. Two patients had only asymptomatic proteinuria with erythrocyturia. The majority suffered from arterial hypertension. The patients were treated with prednisone and cyclophosphamide, using initial doses after which the extrarenal symptoms receded promptly. Regression of proteinuria and normalization of glomerular filtration developed more slowly. Only in one patient the glomerulonephritis had a progressive course and terminated by chronic renal failure. One patient died from septicaemia and one from cardiac failure. The authors assume that early diagnosis and effective combined immunosuppression can ensure a favourable course of this rare disease.

Adult↗
PubMed1993

[Atypical chronic mesangioproliferative glomerulonephritis].

The case report describes the atypical course of a chronic mesangioproliferative glomerulonephritis, which presented with macroscopic haematuria lasting continuously almost 9 years. Proteinuria and macroscopic haematuria ceased after tonsillectomy and a prolonged corticosteroid therapy.

Chronic Disease↗
PubMed1992

[Progression of chronic glomerulonephritis. Myths and facts].

Chronic glomerulonephritis is still the most frequent cause of irreversible renal failure. The aetiology of the majority of glomerulonephritis is unknown but it seems that they are genetically determined. In their genesis immunological factors participate but in their development and progression non-immunological factors are also involved. The author presents a review of contemporary therapeutic possibilities.

Chronic Disease↗
PubMed1991

[The effect of decreased thromboxane synthesis on proliferative glomerulonephritis].

The authors investigated in 19 patients with chronic proliferative glomerulonephritis the effect of 100 mg acetylsalicylic acid (ACA) administered for 12 months and the effect of 50 mg ACA administered for the same period. They evaluated the effect of the two doses on the urinary excretion of PGI and TXA2 metabolites as well as the effect on proteinuria and glomerular filtraction (GF). The authors provided evidence that small and very small amounts of ACA did not affect the excretion of the PGI metabolite, while they reduced significantly the excretion of the TXA2 metabolite and of proteinuria, and significantly increased GF.

6-Ketoprostaglandin F1 alpha↗
PubMed1990

[Recurrence of idiopathic membranous glomerulopathy].

In 30 patients with idiopathic membranous glomerulopathy during prednisone treatment and prednisone and cyclophosphamide treatment resp. partial or complete clinical remission was recorded. In the course of the investigation (118 +/- 77 months) in 7 patients 1-4 relapses occurred. The relapses occurred more frequently in women. There was no difference between the two groups as regards clinical manifestations and morphological findings at the onset of the disease. All relapses were treated in the same way as the first attack. Treatment had in all patients the same result as during the first attack and in the course of the investigation in none of the patients deterioration of renal functions was recorded. In case of effective immunosuppressive treatment the prognosis of patients with relapses is not worse than in patients without relapses.

Adolescent↗
PubMed1990

[Treatment of chronic glomerulonephritis with small doses of acetylsalicylic acid].

The purpose of the investigation was to evaluate the long-term administration of 100 mg acetylsalicylic acid in patients with chronic proliferative glomerulonephritis. Two 12-month periods are compared in the same patients (n = 19) without and with treatment. Glomerular filtration and quantitative proteinuria did not change significantly one year prior to treatment. During treatment glomerular filtration increased from 1.22 +/- 0.37 to 1.70 + 0.55 ml/s (p less than 0.01) and proteinuria declined from 2.6 + 1.1 to 1.6 +/- 1.0 g/24 h (p less than 0.01). Treatment did not influence the excretion of the metabolite prostacyclin 186 +/- 56 and 189 + 75 ng/24 h resp., and significantly reduced the thromboxane excretion from 565 +/- 267 to 348 + 123 ng/24 h, p less than 0.01). The authors assume that long-term treatment could influence in a favourable way the course of chronic proliferative glomerulonephritis.

Adult↗
PubMed1990

[Manifestations of dysfunction of the proximal tubules after intravenous urography].

The aim of the work was to investigate functional changes of tubular cells after i.v. urography. As evidence the authors used assessment of urinary levels of membrane-bound enzymes--alkaline phosphatase (AP), gamma-glutamyl-transpeptidase, lysosomally bound enzymes N-acetyl-beta-D-glucosaminidase and its isoenzyme B and the low molecular protein, beta-2-microglobulin. The above substance were assessed in 15 patients with different nephropathies where i.v. urography was indicated. The examinations were made in 24-hour urine samples before i.v. urography and in two 24-hour samples after administration of the contrast substance. In all patients a significant rise of tubular enzyme excretion was observated as well as of beta-2-microglobulin. The greatest rise was recorded in alkaline phosphatase in the second sample after administration of the contrast substance (432% of the initial value). Beta-2-microglobulin and N-acetyl-D-glucoseaminidase rose already during the first collection period (B2M to 357% and NAG to 181% of the initial values). The authors conclude that i.v. urography made by hyperosmolar iodinated preparations (Verografin, Iodamide) significantly affects the function and integrity of the proximal tubule. The applied spectrum of examinations is suitable also for further investigations of the effect of contrast substances on cells of the proximal renal tubule.

Adult↗
PubMed1990

[Kidney involvement in cryoglobulinemia].

The authors provide the reported data on renal impairment in mixed cryoglobulinemia (CGE) and 3 own CGE case reports. Renal impairment by the type of rapid-progressing nephritis with episodes of acute renal failure was the major sign in the clinical picture of those cases.

Adult↗
PubMed1990

[The effect of acetylsalicylic acid and dipyridamole on glomerular filtration and proteinuria in chronic glomerulonephritis].

The authors treated 14 patients with chronic proliferative glomerulonephritis for one year with acetylsalicylic acid--400 mg/day--and dipyridamole--225 mg/day. They investigated changes of glomerular filtration and proteinuria before treatment, during treatment and one year after its completion. They found that in the course of treatment proteinuria did not change and glomerular filtration declined insignificantly. During the subsequent year proteinuria and glomerular filtration declined significantly. The above findings can be partly explained by changes in the synthesis of renal prostacyclin and thromboxane. The combination of acetylsalicylic acid and dipyridamole in the amounts used did not have a favourable effect on glomerular filtration in patients with chronic proliferative glomerulonephritis.

Adult↗
PubMed1989

[Treatment of chronic proliferative glomerulonephritis using acetylsalicylic acid and dipyridamole].

Fourteen patients with chronic proliferative glomerulonephritis were given for the period of one year 400 mg acetylsalicylic acid and 225 mg dipyridamole per day. During this treatment the thrombocyte aggregation became normal, however, the mean reduction of antiheparin plasma activity was not statistically significant. Normal synthesis of renal prostacyclin declined significantly as a result of treatment, while the renal thromboxane A2 synthesis remained normal even during treatment. Treatment did not influence proteinuria. The mean annual decline of glomerular filtration was greater during the investigation period than the mean annual decline in previous years, the difference was, however, only at the borderline of statistical significance. The authors did not prove a favourable effect of this treatment in patients with chronic proliferative glomerulonephritis.

Adult↗
PubMed1989

[Prostaglandins and chronic proliferative glomerulonephritis].

In 14 patients with chronic proliferative glomerulonephritis, corrected arterial hypertension and normal or marginal glomerular filtration the authors assessed plasmatic and urinary metabolites of PGI2 and TXA2. They found that the production of both PGI2 and TXA2 was raised in the organism and they assume that in the stimulated synthesis hypertension and its treatment participated. The production of both prostaglandins in the kidneys was, however, normal.

6-Ketoprostaglandin F1 alpha↗
PubMed1988

[Cryoglobulinemia].

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Cryoglobulinemia↗