Biomedical subjects

V Konov

Publications and source records attributed to V Konov.

5 recordsLinked to original sources

PubMed1988

[Regulation of oxidative phosphorylation, K+ ions transport and the volume of mitochondrial matrix by cytoplasmic glycopeptide and Ca2+ ions].

A thermostable low molecular weight glycopeptide containing syalic acids, which uncouples mitochondrial oxidative phosphorylation, has been detected, isolated and purified from rat liver cytoplasm. In the presence of the glycopeptide, oxidative phosphorylation in rat liver mitochondria is uncoupled by low physiological concentrations of Ca2+, which otherwise do not have any appreciable effect on the mitochondria. Oxidative phosphorylation uncoupling by the glycopeptide is accompanied by an increase of the mitochondrial volume. This process has a limited amplitude and is regulated by changes in Ca2+ concentration in the extramitochondrial space. The glycopeptide has been shown to induce K+ transport across the inner mitochondrial membrane, this effect is enhanced by Ca2+.

Animals↗

PubMed1987

[Etiology of salmonellosis in swine raised commercially].

A total of 25,561 samples from swine (cadavers, internal organs, rectal swabs, feed, and washings of premises) were investigated microbiologically over the 1981-1985 period via routinely employed methods for the isolation and typing of Salmonella organisms, following the Kauffmann-White pattern. Tested was the susceptibility of 411 strains by the disk-diffusion method, using drugs of the general practice, and the results were recorded after Bauer. In 5.32 per cent of the samples 19 Salmonella serotypes of the B. C. D, and E groups were isolated. Greatest in the etiology of salmonelloses was still the relative share of S. cholerae suis (85.22%), represented by the two-phase var. america and the autochthonous var. kunzendorf. Second ranked S. typhimurium--5.14%, followed by S. agona--2.20%, S. menden--1.25%, S. thompson--1.18%, S. derby--1.10%, S. bovis-morbificans--0.81%, and others. A change was ascertained in the serotypes isolated from pigs with regard to the exotic types. Sensitive to gentamycin proved 89.9%, to chloramphenicol--79.1%, to carbenicillin--71%, to kanamycin--70%, etc; 75% were resistant to ampicillin, 54.6%--to streptomycin, 51.3%--to tetracycline, and 33.8%--to furazolidone.

Animal Husbandry↗

PubMed1985

[Epizootiological research on salmonellosis in swine].

The epizootiology of Salmonella infections in swine was studied in 1970-1980 in 7 districts of this country on a number of farms and industrial complexes in order to elucidate some aspects of the epizootiologic process. A total of 26,957 samples taken from swine and the environment were studied bacteriologically. An industrial complex in each district served as a test one to investigate samples from various groups of swine in the technologic process. It was found that salmonelloses did exist, and Salmonella organisms were isolated from pigs on all studied farms and complexes, however, no diseases and organisms were recorded with both animals and the environment in Swine Nucleus Bases. On the complexes Salmonellae were isolated from pigs of all technologic groups, and, in most cases, the Salmonella species coincided by sows and pigs. This explained the stationary character of the disease on some complexes where a sui generis epizootic process ran its course, exhibiting particular aspects and correlations. Salmonella organisms were isolated in 0.95 per cent of the investigated samples from the test groups on the test complexes as well as in 4.13 per cent of the groups out of the experiment. In samples taken from other complexes, farms of AIC, IAC, auxilliary farms, etc., there were positive findings in 5.32 per cent of the cases. Enzootics on the complexes were most common with pigs aged 40-50 days as against farms with traditional types of technology where 2-4-month-old pigs were involved.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

PubMed1984

[Etiological studies of salmonellosis in swine].

A total of 25,114 samples taken from fetuses, pigs, adult swine, feces, environmental objects, etc. in 6 regions of this country were studied bacteriologically in 1976-1980, and in 1970-1975 a retrospective analysis was made of data of investigations with pigs in the same regions. The sample study led to the isolation of 1,495 strains of 21 Salmonella species of the B, C, D, and E groups. At the same time 9 Salmonella species were isolated from pigs, while during the second period the number of the isolated Salmonella spp. was 16. It was found that the strains belonging to S. cholerae-suis were highest in number (87.61 per cent of all isolated strains), whereupon beside the autochtonic var. kunzendorf there were also findings of var. america. By frequency of isolation the ubiquitous S. typhi-murium ranked four as isolated from pigs, and washings from environmental objects as well as from sewage water, rats, and common flies. Of the exotic Salmonella species more important proved S. agona, S. jerusalem var. 14, S. tennessee, and others. Considerable diversity was established with the Salmonella species in pigs on the industrial complexes (17 spp.), the farms of the Agro-Industrial and the Industrial Agrarian Complexes (8 spp.), and on some other farms (5 spp.). Only two species of Salmonellae were found in pigs on the private farms, and one species--on the auxilliary farms.

Animals↗

PubMed1980

[Reactivity changes in calves during transportation].

The activity of 38 calves aged 15-30 days of the Simenthal breed and of crosses with Ireshire was studied before and after transportaton at a distance of 38-100 km. It was established that transportation causes fatigue, thirst and a weight reduction of 4.3 kg, due to loss of liquid in the calf's organism. Caughing, soft faeces, even diarrhea, 1.5 degrees C higher rectal temperature, and 3.0 degrees C lower skin temperature, were recorded. the MacClure--Oldridge test proved twice as fast. As a result of hemoconcentration hemoglobin and hematocrite were higher. Eosinopaenia and neutrophylia with a nuclear deviation to the left similar to the reaction of experimentally induced lipopolysaccharide fever were established. On the 72d hour lymphocytosis and an enhanced lymhocytal index were observed. Transportation led to 15-18% higher number of phagocyted neutrophyls, 30-35% higher Wright number and nearly two times higher total blood phagocytal ability. Seventy two hours after two times higher total blood phagocytal ability. Seventy two hours after transportation the total blood phagocytal ability was reduced 15%. Another effect of calf transportation was the reduced total immunological reactivity, scored by the skin test of Yoffe.

Animals↗