Biomedical subjects

V Kostić

Publications and source records attributed to V Kostić.

At least 19 recordsLinked to original sources

PubMed1997

Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat.

The present study was undertaken to elucidate whether electrolytic lesions of nucleus basalis magnocellularis--NBM (an animal model of Alzheimer's disease--AD) may influence humoral and cellular immune responses in adult male Wistar rats. For this purpose intact control (IC), sham-operated (SO) and NBM-lesioned rats were divided into two main groups: (1) rats immunized with sheep red blood cells (SRBC) for plaque-forming cell (PFC) response and anti-SRBC agglutinins, and (2) rats immunized with bovine serum albumin in complete Freund's adjuvant (BSA-CFA) for anti-BSA antibody production, Arthus and delayed hypersensitivity skin reaction to BSA. PFC responses and anti-SRBC agglutinins as well as diameter and expression of edema/induration of Arthus/delayed skin reaction and titer of anti-BSA antibody were significantly lower in NBM lesioned rats (compared to IC and SO). The results showed that in NBM-lesioned rats both the humoral and cellular immune responses were suppressed.

Agglutination Tests↗

PubMed1996

Central changes in muscle fatigue during sustained submaximal isometric voluntary contraction as revealed by transcranial magnetic stimulation.

Changes in responses to transcranial magnetic stimulation (TMS) during submaximal isometric voluntary contraction (60% of maximal voluntary contraction (MVC) of the adductor pollicis muscle and the subsequent recovery period have been studied in healthy volunteers. TMS at twice the motor threshold was applied during the sustained contraction, as well as at rest and during short-lasting (2 s) 60% MVCs before and immediately after the sustained contraction, and at 5 min intervals during the recovery period. Both motor evoked potential (MEP) magnitude (peak and area) and silent period (SP) duration in electromyographic activity (EMG) of the adductor pollicis muscle showed a gradual decrease up to the endurance point and an increase thereafter. MEPs elicited at rest immediately after the fatiguing contraction were larger, whereas those elicited later on during the recovery period did not differ significantly from the controls. It is suggested that the changes in responses to TMS, divergent from those in ongoing voluntary EMG during the sustained 60% MVC, indicate complex processes at levels preceding the motor cortex output cells in an attempt to maintain a submaximal contraction of the fatigued muscle. The increase in MEP magnitude after the sustained 60% MVC may indicate residual changes in cortical activity after fatiguing contraction.

Adult↗

PubMed1996

Enteroaggregative Escherichia coli associated with an outbreak of diarrhoea in a neonatal nursery ward.

Over a 9-day period in February 1995, 16 newborn babies (age range 2-11 days) and 3 infants (24, 47 and 180 days of age) in a neonatal nursery ward developed diarrhoea accompanied by pyrexia and weight loss. Known enteropathogens were not detected in their stools but Escherichia coli displaying aggregative adherence to HEp-2 cells (enteroaggregative E. coli) were found in 12 (63%) ill infants and in none of 5 well neonates (P = 0.02). The illness lasted 3-9 days (mean 5.2) in 16 babies, whereas in 3 neonates it showed a protracted course of 18-20 days. The source of infection and the mode of transmission remained unclear. The outbreak isolates manifested properties common in this new group of diarrhoeagenic E. coli: mannose-resistant haemagglutination, haemolysis on blood agar, and clump formation in liquid culture medium. They belonged to the O4 E. coli serogroup and expressed multiple antibiotic resistance.

Bacterial Adhesion↗

PubMed1990

[Not Available].

Explore the source record for details and available documents.

Communicable Disease Control↗

PubMed1990

[Changes in sleep in Parkinson's disease].

In a sample of 44 patients with Parkinson's disease, REM latency showed a unimodal rather than bimodal distribution, with peak frequency between 0-10 min. A total of 16 patients exhibited (36.4%) a sleep onset REM period (SOREMP-10); i.e. REM latency of 10 min during the night; an additional 4 patients (9%) showed REM latencies of 11-20 min, while 8 patients (18.2%) showed REM latencies of less than 50 min (63.6 of the total sample). Patients with REM latencies of less than 50 min were older, both at the time of study and at the age of onset of the disease. There were more patients with depressive syndrome in this group than in the other group. They also showed a higher sleep amount. No other clinical or polysomnographic differences were found between patients with short REM latencies and patients exhibiting REM latencies of more than 50 min. Very short REM latencies probably reflect depressive syndrome associated with Parkinson's disease.

Adult↗

PubMed1990

Local treatment of spasmodic torticollis with botulinum toxin.

Fifteen patients with spasmodic torticollis were treated with local injections of botulinum--A toxin. All the patients were followed for a period of 4 to 7 months. Thirteen out of 15 patients (86%) improved in the amount of sustained movements of torticollis. In six out of 9 patients presenting with pain complete relief was noted. Beneficial effects of botulinum toxin injections lasted from 2 to 3 months, with reproducible efficacy after repeated injections. The most frequent side effect was dysphagia, presented in 10 patients.

Adult↗

PubMed1989

[Clinical characteristics of progressive supranuclear paralysis (the Steele-Richardson-Olszewski syndrome)].

We analyzed the clinical features and therapeutic response of 6 patients with progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome). The mean duration from the onset to establishing the diagnosis was 2.7 years, with the initial false diagnosis of Parkinson's disease in 4 patients. The most common symptoms at the moment of diagnosing were unsteady gait, speech difficulties, forgetfulness and rigidity, in addition to impairment of vertical gaze. In all the patients therapeutical response was inadequate. Clinical criteria for differential diagnosis of progressive supranuclear palsy are discussed.

Aged↗

PubMed1988

Serum immunoinhibitory factors in stroke patients.

Immunoinhibitory factors in the sera of stroke patients were studied by an analysis of their capacity to influence the in vitro proliferative response of T cells. The evidence was obtained that the sera from stroke patients exhibited inhibitory activity on T cell proliferation. Although the nature of these inhibitory factors was not analyzed, it was clearly shown that their activity correlated with the degree of neurological defects, indicating that their determination may be of some prognostic value.

Adult↗

PubMed1987