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Biomedical subjects

V Kren

Publications and source records attributed to V Kren.

At least 181 records · Page 10Linked to original sources
PubMed1981

Evidence for polymorphism of alloantigenic transplantation products of the histocompatibility locus (H-4) in linkage group I of Rattus norvegicus.

An alloantigenic transplantation system linked to the gene for albinism in linkage group I of Rattus norvegicus has been identified in the congenic pair LEW--LEW.C-4A and designated H-4. Alloantigenic transplantation products of the H-4 system are relatively "weak" because the majority of skin grafts exchanged between animals of the congenic pair (LEW--LEW.C-4A) survive permanently without previous sensitization of the recipients. Presensitization of the congenic recipients with lymphoid cells results in a marked increase in the incidence and acceleration of graft rejection. The testing of F1 hybrids of the eight inbred rat strains with strains LEW and LEW.C-4A by skin or tumour transplantation shows that alleles other than H-4a or H-41 are present in three strains, thereby demonstrating polymorphism of the H-4 system with the existence of minimally three alleles.

Alleles↗
PubMed1981

A contribution to the relationship between tumour cell social behaviour in vitro and malignancy in vivo.

Membrane activity of high malignant (grade IV in the immunogenetic test of malignancy) cells was found to continue along the contacting edge after random collision with normal cells in vitro, as demonstrated by the high resolution time-lapse cinemicrography. This preservation of surface activity was the main difference in social behaviour of high and low malignant rat tumour cells upon random collision with normal cells in four lines of tumour cells investigated.

Animals↗
PubMed1980

[Morphological changes in the transplanted rat kidney under conditions of minor and major histocompatibility differences between donor and recipient].

Morphological changes in transplanted kidney were studied in 4 groups of rats with different histocompatibility differences between donor and recipient: 1. syngenetic differences, 2. differences in the main histocompatibility system H-1, 3. differences in the H-1 as well as in the subsidiary non-H-1 systems, 4. differences in the non-H-1 systems. -- In all the kidneys transplanted from a newly developed congenetic strain BP.1N to inbred rats of the BN strain (with differences in the non-H-1 systems) rejection developed in 2 to 3 weeks with manifestations of giant-cell interstitial nephritis with gradual destruction and phagocytosis of cortical tubules probably due to the production of antibodies against the basal membranes of tubules. -- In the paralel group with differences in the non-H-1 systems of BP into BN-1B, destroyed after 30 days, there were -- in addition to moderate acute rejection -- hypercellular glomerules with electrodense deposits in the mesangium seen as a manifestation of immuno-complex glomerulonephritis. Analogical glomerular changes without rejection were also fond in a control group of longer surviving syngenetic rats.

Animals↗