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Biomedical subjects

V Kunze

Publications and source records attributed to V Kunze.

24 records · Page 2Linked to original sources

[Computerized tomography and magnetic resonance tomography in soft tissue tumors].

The modern cross-sectional imaging techniques, e.g. CT and MR, have brought about a significant improvement in the diagnosis of soft tissue tumors. CT allows these neoplasms to be detected with relatively high sensitivity and their extension to be assessed. MR has proved to be superior to CT owing to the high soft tissue contrast it provides and its multi-planar imaging capabilities. Gadolinium-DTPA, a paramagnetic agent, can be utilized to good advantage as contrast material in MR; it yields further information as to the malignancy or otherwise of particular tumors. In addition, differentiation of tumor recurrences from other postoperative alterations seems to be feasible.

Humans↗

[Possibilities of magnetic resonance tomography in diagnostic imaging of the shoulder joint].

By virtue of its multiplanar representation, magnetic resonance imaging (MRI) allows clear visualization of the complex anatomical relationships of the shoulder joint. In addition to axial planes, slices perpendicular and parallel to the glenoid cavity are used to good advantage. In tears of the rotator cuff an increase in signal intensity within the cuff is recognized in T2- and proton-density-weighted images. Lesions of the glenoid labrum following luxations of the glenohumeral joint can be detected and classified using MRI. The diagnostic value of MRI as compared with other imaging modalities will have to be evaluated in larger series with operative verification.

Arthrography↗

[Time-dependent changes in signal intensity in neoplastic and inflammatory lesions of the musculoskeletal system following intravenous administration of Gd-DTPA].

In 48 patients with primary and secondary bone and soft tissue tumors and in 6 patients with inflammatory diseases of bone, the increase in signal intensity after i.v. administration of Gd-DTPA (0.1 mmol/kg body wt) was assessed in pathologic and normal tissues of the musculoskeletal system by means of a FLASH sequence (TR = 40 ms, TE = 10 ms, tip angle 90 degrees). In normal tissues the increase of signal intensity was slower and less pronounced than in lesions. Malignant tumors showed a more pronounced and rapid increase in signal intensity than benign tumors and inflammatory tissue. It was possible to differentiate necrotic areas and peritumorous edema from tumorous and inflammatory tissue. The increase in signal intensity was perceptibly slower and less pronounced in malignant tumors exposed to cytostatic therapy than in malignant tumors without therapy.

Bone Neoplasms↗

[Initial experiences with gadolinium DTPA in magnetic resonance tomography of bone and soft tissue tumors].

MR was performed in 41 patients suffering from benign and malignant bone and soft-tissue tumor before and after intravenous injection of the paramagnetic agent gadolinium-DTPA (Gd-DTPA). Using T1-weighted parameters, the contrast of tumor tissue versus muscle could be increased by Gd-DTPA. Thus, extraosseous extension as well as infiltration of the spinal canal was depicted to better advantage. Inhomogeneities were visualized with higher frequency and improved contrast. In several instances, there was no differentiation between tumor and adjacent edema without application of Gd-DTPA. T2-weighted images without Gd-DTPA exhibited higher contrast as compared to T1-weighted images after Gd-DTPA. The contrast to tumor tissue versus fat and bone marrow respectively was reduced after applying Gd-DTPA. Thus, for the evaluation of bone marrow infiltration, T1-weighted images without Gd-DTPA proved to be indispensable.

Adolescent↗