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Biomedical subjects

V L Belianin

Publications and source records attributed to V L Belianin.

At least 19 recordsLinked to original sources

[Mitotic activity in serous adenocarcinoma of the uterine body].

A comparative study of uterine serous (36) and endometrial (32) adenocarcinoma was undertaken. The former pathology revealed a higher mitotic index (18.2%) than the latter (11.4%) (p < 0.01). Predominance of metaphases among the variety of mitotic phases as well as high metaphase-prophase index (73.6% and 69.2% in serous and endometrial adenocarcinoma, respectively) were typical of malignant tumors in general. The share of patholological mitoses in serous adenocarcinomas was 1.6 times (61.8%) that in endometrial adenocarcinomas. Moreover, serous adenocarcinomas showed a wide range of pathological mitoses which were often responsible for aneuploidy development. The above differences in uterine serous and endometrial adenocarcinoma were in full conformity with the well known aggressive nature of the former pathology and may be used as an additional criterion of differential diagnosis.

Aneuploidy↗

[Morphologic manifestations of candidiasis in newborns with immunodeficiency].

Morphological examinations of 58 autopsy cases of visceral candidiasis in newborns were performed. Direct correlation between the severity of thymus lesions and the degree of changes in organs produced by candidiasis was observed. The most severe candidiasis was found in cases of congenital immunodeficiency. This suggests that the morphological features of candidiasis may be the manifestation of immunodeficiency state.

Candidiasis↗

[Fungus invasion in the morphogenesis of gastro-duodenal ulcers].

The goal of the study was the clarification of the role of the fungus Candida in the course of the ulcer. The combination of morphological, cultural and immunological methods was used for the diagnosis of the fungus involvement. Inhibition of the reparative processes by the fungus Candida was shown in the experiment on the model of the chronic gastric ulcer. It is concluded that in patients with chronic ulcers histological examination of the biopsies for fungi should be performed.

Adult↗

[Species characteristics of experimental Candida lung lesions].

Intratracheal challenge of rabbits and intranasal challenge of white mice and guinea-pigs by C. albicans without the application of adhesive substances, produced candidiasis pneumonia running more severe course in mice than in rabbits. In guinea-pigs the disease was of medium severity. Specific features of pulmonary inflammation in rabbits were marked polynuclear and especially macrophage reactions, with the phagocyte activity high enough to ensure total elimination of pathogenic microorganisms in the animal. In white mice a weak macrophage reaction was actually a background for a predominant polynuclear reaction producing a massive polynuclear leukocyte disintegration. These processes, though eliminating pathogenic organisms both by phagocytosis and non-phagocytic mechanisms, lead to severe fatal pulmonary edema. Specific differences in experimental lung candidiasis reveal various manifestation of human lung candidiasis.

Animals↗

[Morphogenesis of candidiasis granuloma].

Fungi C. albicans killed by various methods were injected intravenously to mice resulting in the granuloma formation in the liver and spleen. These granulomas were similar to those developing in newborns affected with candidiasis. The components of the fungus cellular wall are responsible for the granuloma development and act as the antigenic material. Polynuclears which are capable of dealing with the antigenic material more actively than mononuclear liver phagocytes, play an essential role as the trigger mechanism in the granuloma formation produced by the killer C. albicans. At the same time long persistence of C. albicans antigenic material in the granulomas proves the deficiency of the phagocytic response directed to the utilization of this material. It is assumed that similar mechanisms are responsible for the morphogenesis of both human candidiasis granulomas and those produced by the killed C. albicans.

Animals↗

[Morphofunctional state of organs of immunogenesis and adrenal glands after administration of a thymus preparation (thymaline)].

Comparative characterization of morphofunctional changes in the thymus, secondary immunogenesis organs, and adrenal cortex after 10-day subcutaneous inoculations of CBA mice with a thymus preparation, thymaline, showed enhanced thymus functioning and not very marked signs of migrational activity of lymphocytes in lymph nodes under conditions of a prolonged effect of thymaline in normal animals to run in a reduced hormonal activity of adrenocorticocytes.

Acid Phosphatase↗

[Candidiasis in newborn infants].

Morphological observations of 11 cases of candidosis in newborn infants are presented. Candidosis runs the course of sepsis either with predominant involvement of the brain or with involvement of the brain and internal organs. The process was well-defined in underdeveloped babies and occurrred in all prematurely born babies. The babies could contract the infection in the three ways; in utero, in the course of passing the genital tract, or immediately after the delivery. The nature of the infection can be determined only on the basis of tissue reactions developing in response to Candida vegetation.

Autopsy↗

[Differential diagnostic possibilities based on algorithms from histological study in cervical and vaginal diseases].

An algorithm of histological description of pathological processes in the cervix uteri and vagina is proposed to improve the quality of differential histological diagnosis of diseases of these organs. The algorithm ensures a better analysis of the data obtained by organizing the thinking of a pathologist, contributes to fuller and more fruitful use of recommendations of both descriptive and morphometric nature, and may be used for research and training and self-training of morphologists.

Biopsy↗

[Spirochetes on the mucous membrane of the intestine].

Recently, it has been discovered that the mucosa of the large intestine and that of the appendix in man and in monkeys not infrequently is covered densely with spirochetes penetrated therein. These observations were confirmed by the material studied by the authors (specimens of the mucosa of the sigmoid flexture of 45 people, the specimens being obtained by means of aspiration biopsy, and the intestines of five monkeys). It was also established that spirochetes may also densely penetrate, covering almost entirely, into the inner surface of the large intestine, as if substituting by themselves for mircovilli of the epithelial cells. Such parasitism, however, does not produce any local reaction, and apparently, inflicts no special harm.

Animals↗

[Mechanisms of cellular defense in cadidiasis].

The data obtained in this research on experimental lung candidiasis in mice suggest that a specific part of cellular resistance (thymus) evidently fails to play the leading role in initiating the infectious process. The major function of hindering candidiasis development belongs to neutrophilic leucocytes whose phagocytosis is eliminating the causal agents from the organism.

Animals↗