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V L Hennessy

Publications and source records attributed to V L Hennessy.

4 recordsLinked to original sources

Results of operations upon abdominal aortic aneurysms at a community hospital.

Review of a retrospective series of 140 consecutive abdominal aortic aneurysms in a community hospital has disclosed a low operative mortality and a low morbidity rate. Seventy patients were more than 70 years of age. Of 82 patients operated upon before rupture of the aneurysm, three died and 11 had complications. Of 38 patients operated upon after rupture of the aneurysm, 22 died and eight had complications. The age of 70 years or older and shock were identified as significant risk factors adversely affecting the outcome of operations done as an emergency upon patients with ruptured aneurysms. Renal failure occurred only in patients with ruptured aneurysms; when renal failure did occur, it was usually fatal. Myocardial infarction seldom occurred after elective operations because of aggressive, thorough cardiac evaluation, including selective coronary arteriography. Myocardial infarctions contributed to the deaths of six patients in whom the aneurysms ruptured prior to operation.

Aged

Function of human platelets during extracorporeal circulation.

The interaction between human platelets and nonbiologic surfaces was studied during in vitro recirculation of 500 ml of fresh, heparinized human blood in four different perfusion circuits. Circuits differed in surface area (0.1 m2 or 0.9 m2) and in surface composition. No important differences were observed between standard silicone-rubber and filler-free, silicone-rubber surfaces. Platelet counts decreased to 85% of control in 0.1- m2 circuits, but retained normal sensitivity to aggregating agents and released only small amounts of platelet factor 4 (PF4). In contrast, platelet counts in 0.9-m2 circuits decreased to 20% of control within 2 min and platelet sensitivity was depressed out of proportion to the fall in platelet count. Plasma PF4 progressively increased and platelet PF4 content progressively decreased during 6 h of recirculation. The results indicate that human platelets may exist in three conditions during extracorporeal circulation. Some platelets are unaltered, some are less sensitive to aggregating agents, and others have undergone extensive release. The ratio of blood volume to surface area appears to be an important determinant of platelet-surface interaction.

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