Biomedical subjects

V L Holt

Publications and source records attributed to V L Holt.

At least 37 records · Page 2Linked to original sources

PubMed1997

The association of change in maternal marital status between births and adverse pregnancy outcomes in the second birth.

The relationships between change in marital status between two consecutive births and adverse pregnancy outcomes at the second birth were investigated using linked Washington State 1980-93 white singleton birth certificates. Women who were married at the first birth had lower low birthweight (LBW) and small-size-for-gestational-age (SGA) rates at that birth than single women, and women married at the second birth had lower LBW, SGA and preterm delivery rates at that birth regardless of marital status at the first birth. Adjusted relative risks (RR) of LBW and SGA were significantly increased for initially married women who were single at the second birth compared with those who remained married (RR = 1.4 and 1.3, respectively). Risks of LBW and SGA were significantly decreased among initially single women who married by the second birth, compared with those remaining single (RR = 0.7 for LBW and 0.8 for SGA). We conclude that the largely unstudied subgroup of previously married women is at increased risk for adverse pregnancy outcomes. Public health policy and programmes directed at high-risk mothers and infants should be aware of the specific physical and emotional needs of this group of child-bearing women.

Adult↗

PubMed1997

Attempt and success rates for vaginal birth after caesarean section in relation to complications of the previous pregnancy.

The relationships between prior obstetrical complications and subsequent trial of labour and vaginal birth after Caesarean (VBAC) success likelihood were examined among a cohort of Washington State women with a first livebirth via Caesarean delivery and a second livebirth between 1987 and 1993 (n = 10110). Overall, 64% of the cohort undertook a labour trial, and 62% of those who attempted VBAC delivery were successful, for an overall VBAC rate of 40%. Women with fetal macrosomia, cephalopelvic disproportion, prolonged labour, diabetes, or placental problems in the first pregnancy were less likely to undergo a labour trial in the second pregnancy than those without these factors, while women with prior induced labour, genital herpes, fetal distress, or breech presentation were more likely to attempt vaginal birth. Approximately half of women with prior macrosomia, labour problems, or chronic medical conditions who attempted VBAC succeeded, as did three-quarters of women with prior breech presentation or placental conditions. Overall VBAC rates were around 33% for women with previous fetal macrosomia, labour problems, or chronic medical conditions, and 45-55% among those with herpes, fetal distress or breech presentation at the first birth. Trial of labour should especially be encouraged among women without prior labour problems.

Adult↗

PubMed1997

What do women want to know after childbirth?

BACKGROUND: Postpartum women have demonstrated a variety of health care concerns. This study, conducted in Washington state in 1991, investigated predictors of primiparas' and multiparas' desire to receive more information about 18 self-care and baby care topics at 7 weeks postpartum in relation to prenatal class attendance, short postpartum hospital stay, and other variables. METHODS: Data from 1161 women who completed a survey were analyzed. Percentages of women desiring more information on each topic were calculated stratified by parity; mean numbers of chosen health topics were calculated in relation to prenatal education, length of postpartum hospitalization, maternal age, education, social support, and type of delivery; and association between desire for more information on specific topics and length of postpartum hospitalization, maternal age, maternal education, and social support were calculated. RESULTS: Over three-fourths of women wanted more information on at least one topic, and the highest percentage wanted more information on exercise, diet, and nutrition; getting along with their other children; and recognizing infant illness. Primiparas and multiparas who desired more information were under 25 years of age and had low levels of social support; in addition, multiparas with unmet information needs had low education and short postpartum stays. Prenatal education was unrelated to postpartum desire for more information. CONCLUSION: Most postpartum women want self-care and baby care information, a need that is not completely met by prenatal or postpartum education. Postpartum follow-up programs with a strong educational component and special targeting of high-risk women may enable health caregivers to better address this need.

Adolescent↗

PubMed1995

Recent changes in delivery site of low-birth-weight infants in Washington: impact on birth weight-specific mortality.

OBJECTIVES: Our purpose was to ascertain whether the proportion of low-birth-weight infants delivered in Washington at tertiary hospitals changed between 1980 and 1991 and whether mortality differed by level of birth hospital. STUDY DESIGN: A retrospective cohort study was performed of 500 to 2499 gm infants born to Washington residents between 1980 and 1991 (n = 43,228). RESULTS: Overall, the percentage of low-birth-weight infants born at tertiary centers rose from 1980 to 1982 through 1986 to 1988 and subsequently declined significantly. Among infants weighing < 2000 gm nontertiary delivery was associated with greater potentially preventable mortality (500 to 999 gm, relative risk 1.5, 95% confidence interval 1.3 to 1.8; 1000 to 1499 gm, relative risk 2.1, 95% confidence interval 1.3 to 3.3; 1500 to 1999 gm, relative risk 1.6, 95% confidence interval 1.0 to 2.6). Nontertiary delivery of 2000 to 2499 gm infants was associated with lower overall mortality (relative risk 0.5, 95% confidence interval 0.3 to 0.8), but higher-risk deliveries in this birth weight range were apparently concentrated at tertiary hospitals. CONCLUSIONS: In light of the apparent benefit of tertiary center birth for infants weighing < 2000 gm, the possible erosion of effective regionalized perinatal care networks should be monitored closely.

Adult↗

PubMed1995

The intergenerational relationship between mother's birthweight, infant birthweight and infant mortality in black and white mothers.

The relationship between the birthweight of white and black mothers and the outcomes of their infants were examined using the 1988 National Maternal and Infant Health Survey. White and black women who were low birthweight themselves were at increased risk of delivering very low birthweight (VLBW), moderately low birthweight (MLBW), extremely preterm and small size for gestational age (SGA) infants. Adjustment for the confounding effects of prepregnant weight and height reduced the risks of all these outcomes slightly, and more substantially reduced the maternal birthweight associated risk of moderately low birthweight among white mothers. There was little effect of maternal birthweight on infant birthweight-specific infant mortality in white mothers; however, black mothers who weighed less than 4 lbs at birth were at significantly increased risk of delivering a normal birthweight infant who subsequently died. Although the risks for the various outcomes associated with low maternal birthweight were not consistently higher in black mothers compared with white mothers, adjustment for prepregnant weight and height had a greater effect in white mothers than in black mothers. We suggest that interventions to reduce the risks for adverse pregnancy outcomes associated with low maternal birthweight should attempt to optimise prepregnant weight and foster child health and growth.

Adult↗

PubMed1994

Adequacy of well-child care and immunizations in US infants born in 1988.

OBJECTIVE: To determine adequacy of preventive care for US infants, including both well-child care visits and immunizations, and to identify risk factors for inadequate receipt of care. DESIGN: Analysis of the 1988 National Maternal and Infant Health Survey of the National Center for Health Statistics. SAMPLE: Nationally representative sample of all US children born in 1988. PARTICIPANTS: A total of 7035 infants from a live-birth subsample who were at least 8 months of age and living with their mothers at the time of the survey. MAIN OUTCOME MEASURES: Percentage of children receiving both adequate well-child visits and adequate immunizations by 8 months of age. RESULTS: Adequate visits were received by 82% of white infants and 75% of black infants; adequate immunizations were received by 46% and 34%, respectively. Forty-two percent of white infants and 29% of black infants received both. Sixty percent of infants who did not have adequate immunizations by 8 months of age had at least three well-baby visits. With adjustment for maternal education level, poor white children had a relative risk of 1.5 of receiving inadequate care compared with infants in families with income greater than 185% of the federal poverty level. Infants with Medicaid or other government assistance had significantly lower levels of adequate care than did infants with private insurance. CONCLUSIONS: This study demonstrates a wide gap between actual immunization coverage levels and recommended levels among US infants born in 1988. Public health agencies, Medicaid programs, and primary care providers should explore ways to take better advantage of well-child visits that are already occurring to achieve appropriate levels of immunization coverage.

Health Priorities↗

PubMed1994

Cigarette smoking and functional ovarian cysts.

This population-based case-control study assessed the effect of current cigarette smoking on the risk of functional ovarian cyst development. Cases were all 15-39 year-old enrollees of Group Health Cooperative of Puget Sound (GHC) who had either an inpatient primary diagnosis of functional ovarian cyst in 1988 or 1989 (n = 61) or an outpatient primary diagnosis of functional ovarian cyst at five GHC primary care clinics (n = 37). Controls were randomly selected enrollees matched to cases on age, primary care clinic, and enrollment date (n = 239). A total of 36.7% of cases and 20.5% of controls were determined by medical record review to be current smokers. Compared with women who were not current smokers, the relative risk of a diagnosed functional ovarian cyst among smokers was 2.0 (95% confidence interval 1.1-3.5). This finding, in an area of little previous research, provides a promising lead in the investigation of the etiology of functional ovarian cysts and the effects of smoking on ovarian function in general.

Adolescent↗

PubMed1994

Effect of changes in maternal age, parity, and birth weight distribution on primary cesarean delivery rates.

OBJECTIVE: To examine the effect of maternal age on cesarean delivery risk and to quantify the impact of demographic changes since 1970 on primary cesarean delivery rates. DESIGN: A cohort study. SETTING: Nonfederal short-stay hospitals in Washington State. PARTICIPANTS: All women who delivered live singletons with linked birth certificate and hospital discharge data from 1987 through 1990. MAIN OUTCOME MEASURES: Maternal age-, birth weight-, and parity-specific primary cesarean delivery rates, Mantel-Haenszel relative risk estimates for primary cesarean delivery by 5-year age category stratified by parity, and direct standardization of 1987 through 1990 primary cesarean rates to 1970 Washington State maternal age, birth weight, and parity distribution. RESULTS: Primary cesarean rates ranged from 3.2% for multiparous teenage women who delivered infants weighing 3500 g through 3999 g to 58.9% for primiparous women 40 years of age or older who delivered infants weighing 4000 g or more. After adjustment, the risk of cesarean delivery increased with each 5-year age increment among women 20 years of age or older. We estimated that if the maternal age, parity, and birth weight distribution from 1987 through 1990 were identical to what existed in 1970, Washington State's primary cesarean rate from 1987 through 1990 would have been 12.2%, compared with the observed rate of 14.8%. CONCLUSION: The lower adjusted primary cesarean rate reflects the demographic changes in the childbearing population, which may be responsible for 18% of the 1987 through 1990 cesarean delivery rates. These findings suggest the importance of using maternal age-, birth weight-, and parity-specific primary cesarean delivery rates to compare populations and study temporal trends.

Adolescent↗

PubMed1994

Health status and timing of onset of prenatal care: is there an association among low-income women?

We examined medical obstetric conditions predating pregnancy and current symptoms as predictors of the timing of the start of prenatal care among low-income women in Snohomish County, Washington. The investigation was a cross-sectional survey with retrospective record review. Subjects were 473 women who sought care through the community health center network, which was the only provider of prenatal care for low-income women in the county at the time of the study. Women with a history of two or more medical or obstetric conditions were more likely than those without such histories to seek prenatal care early in pregnancy. Women who, in the current pregnancy, had few physical symptoms were more likely to delay seeking prenatal care than symptomatic women. Among this relatively homogeneous group, sociodemographic characteristics were not associated with the timing of entry into prenatal care. The findings help to explain the patterns of prenatal care use of certain groups, and suggest avenues for intervention to improve use among low-income women.

Adult↗

PubMed1994

Licensed midwife-attended, out-of-hospital births in Washington state: are they safe?

The safety of out-of-hospital births attended by midwives who are licensed according to international standards has not been established in the United States. To address this issue, outcomes of births attended out of hospital by licensed midwives in Washington state were compared with those attended by physicians and certified nurse-midwives in hospital and certified nurse-midwives out of hospital between 1981 and 1990. Outcomes measured included low birthweight, low five-minute Apgar scores, and neonatal and postneonatal mortality. Associations between attendant and outcomes were measured using odds ratios to estimate relative risks. Multivariate analysis using logistic regression controlled for confounding variables. Overall, births attended by licensed midwives out of hospital had a significantly lower risk for low birthweight than those attended in hospital by certified nurse-midwives, but no significant differences were found between licensed midwives and any of the comparison groups on any other outcomes measured. When the analysis was limited to low-risk women, certified nurse-midwives were no more likely to deliver low-birthweight infants than were licensed midwives, but births attended by physicians had a higher risk of low birthweight. The results of this study indicate that in Washington state the practice of licensed nonnurse-midwives, whose training meets standards set by international professional organizations, may be as safe as that of physicians in hospital and certified nurse-midwives in and out of hospital.

Adult↗

PubMed1994

Pregnancy risk factors and birth outcomes in Washington State: a comparison of Ethiopian-born and US-born women.

This study compared birth outcomes of three cohorts of women with singleton live births in Washington State between 1980 and 1991: all Black Ethiopian-born women (n = 264) and samples of US-born Black (n = 526) and White (n = 546) women. Ethiopians were older, more likely to be married, and less likely to smoke than were US-born women, and they were less likely to have anemia than US-born Blacks. The adjusted low-birthweight risk among Ethiopians was similar to that of US-born Blacks (relative risk [RR] = 0.9) and Whites (RR = 1.1). Ethiopians were more likely to have high-birthweight infants than were US-born Blacks (RR = 4.0). Cultural and behavioral etiologies may explain these favorable birth outcomes.

Adolescent↗

PubMed1993

Variations in the accuracy of obstetric procedures and diagnoses on birth records in Washington State, 1989.

The authors abstracted a sample of 7,536 hospital medical records to validate the accuracy of the coding of obstetric information on 1) birth certificates, 2) a statewide computerized hospital discharge abstract data system, and 3) a linked file merging birth certificates and the hospital abstract data for Washington State deliveries occurring in 1989. Measures of accuracy of coding of delivery method and obstetric procedures varied greatly among the 23 hospitals that participated in the study. Computerized hospital discharge data were generally more complete and accurate than were birth certificate data. The linked file was more likely to identify obstetric procedures than was either source alone. For example, only 84.1% of cesarean deliveries noted in the hospital charts were identified on birth certificates (range among hospitals, 37-100%). Using the linked file, the authors identified 99.8% of cesarean deliveries (range, 97-100%). Linked birth certificate-hospital abstract files may become an excellent source of data for epidemiologic and health care studies; however, further training of medical record personnel and standardization of coding are needed to improve the quality of computerized data on obstetric events.

Birth Certificates↗

PubMed1993

Epilepsy as a risk factor for submersion injury in children.

The purpose of this study was to determine the risk of submersion injury and drowning among children with epilepsy and to define further specific risk factors. In a population-based retrospective cohort study the authors identified and reviewed records of all 0-through 19-year-old residents of King County, Washington, who suffered a submersion incident between 1974 and 1990. Children with epilepsy were compared with those without epilepsy with regard to age, sex, site of incident, supervision, outcome, and presence of preexisting handicap. Relative risks were determined using population-based estimates of epilepsy prevalence. Of 336 submersions, 21 (6%) occurred among children with epilepsy. Children with epilepsy were more likely to be greater than 5 years old (86% vs 47%) and more likely to submerge in a bathtub (38% vs 11%). The relative risk of submersion for children with epilepsy was 47 (95% confidence interval [CI] 22 to 100) in the bathtub and 18.7 (95% CI 9.8 to 35.6) in the pool. The relative risk of drowning for children with epilepsy was 96 (95% CI 33 to 275) in the bathtub and 23.4 (95% CI 7.1 to 77.1) in the pool. These data support an increased risk of submersion and drowning among children with epilepsy.

Adolescent↗

PubMed1992

Functional ovarian cysts in relation to the use of monophasic and triphasic oral contraceptives.

This population-based case-control study assessed the effect of current use of monophasic or triphasic oral contraceptives (OCs) on the risk of functional ovarian cyst development. The cases were all 15-39-year-old enrollees in the Group Health Cooperative of Puget Sound who had either an inpatient primary diagnosis of functional ovarian cyst in 1988 or 1989 (N = 67) or an outpatient primary diagnosis of functional ovarian cyst from March 1988 through August 1989 at one of five Group Health Cooperative primary care clinics (N = 39). Controls were randomly selected enrollees matched to the cases for age, primary care clinic, and enrollment date (N = 255). Subjects with previous hysterectomy or oophorectomy were excluded from this analysis. Pharmacy and medical record review showed that 16% of cases and 19% of controls were currently using monophasic OCs, whereas 11% of cases and 9% of controls were using triphasic OCs. Compared with women not using hormonal contraception, the relative risks of a diagnosed functional ovarian cyst among women currently using OCs were 0.8 (95% confidence interval [CI] 0.4-1.8) for users of monophasic OCs and 1.3 (95% CI 0.5-3.3) for users of triphasic OCs. In contrast to previous studies of monophasic OCs containing higher steroid dosages, the results of this study suggest that current use of low-dose monophasic OCs does not substantially decrease a woman's risk of functional ovarian cyst formation. In addition, our results do not support recent speculation that current use of triphasic OCs appreciably increases the risk of functional ovarian cysts.

Adult↗

PubMed1991

Tubal sterilization and subsequent ectopic pregnancy. A case-control study.

OBJECTIVE: To assess the relative risk of ectopic pregnancy associated with postpartum or interval tubal sterilization. DESIGN: Case-control study using a comparison group of women of reproductive age at risk of pregnancy. SETTING: Group Health Cooperative of Puget Sound, a health maintenance organization based in Seattle, Wash. organization based in Seattle, Wash. PARTICIPANTS: Cases were 249 enrollees diagnosed as having an ectopic pregnancy between October 1, 1981, and September 30, 1986. Controls were 835 randomly selected enrollees matched to cases on age and county of residence. MEASUREMENTS: Information on interval sterilization history was obtained from interviews, examination of medical records, automated hospitalization files and a previously validated algorithm. A logistic regression model was used to estimate relative risks (RRs) for sterilized women compared with women using other types of or no contraception at the reference date. RESULTS: Controlling for age, county, race, smoking, income, gravidity, and prior use of a Dalkon Shield intrauterine device, the risk of ectopic pregnancy in women who had undergone interval sterilization was 3.7 (95% confidence interval [CI], 1.7 to 8.0) times that of women currently using oral contraception and 2.8 (95% CI, 1.5 to 5.5) times that of women currently using barrier contraceptive methods. Use of interval sterilization was associated with a risk of ectopic pregnancy similar to that of women using intrauterine devices (RR, 0.8; 95% CI, 0.4 to 1.7) and a risk lower than that of women who were not using contraception (RR, 0.2; 95% CI, 0.1 to 0.3). The corresponding RRs associated with postpartum sterilization were lower: 1.2 (95% CI, 0.3 to 3.9), 0.9 (95% CI, 0.3 to 2.8), 0.3 (95% CI, 0.1 to 0.8), and 0.1 (95% CI, 0.0 to 0.2), respectively. CONCLUSION: Tubal sterilization provides some protection against extrauterine as well as intrauterine pregnancy. It is likely that postpartum sterilization can be a safe alternative to all types of temporary contraception in terms of risk of ectopic pregnancy, while some types of interval sterilization may lead to an increased risk, in comparison with use of oral contraceptives or barrier methods.

Adolescent↗

PubMed1991

Results and effect of refusal recontact in a case-control study of ectopic pregnancy.

In a population-based study of ectopic pregnancy, a card-back system of initial subject contact yielded a positive response from 85.1% of potential cases and 65.0% of potential controls. We subsequently recontacted by telephone potential controls who had declined to participate and offered them $10 compensation for participation. We recontacted 205 of the 330 control women who had refused to participate. Twenty-eight were found to be ineligible, and 75.7% of the remaining 177 agreed to participate on recontact. The additional 125 women were not recontacted, 9 because of firm initial refusals and 116 because the study ended before contact could be sought or made. Controls who initially declined to participate but subsequently agreed differed from those who initially agreed on a number of demographic and reproductive characteristics, and estimates of ectopic pregnancy risk associated with induced abortion and tubal sterilization changed slightly with the inclusion of initial nonparticipants. We conclude that use of a card-back system of subject contact yields a low level of positive response among reproductive-aged women and that many initial nonparticipants can be converted into participants by personal contact and the offer of compensation.

Adult↗

PubMed1989

Induced abortion and the risk of subsequent ectopic pregnancy.

This study assessed the effect of legal induced abortion on ectopic pregnancy risk by using a comparison group of reproductive-age women who were at risk of becoming pregnant during the same time period the women with ectopic pregnancy conceived. Cases were members of Group Health Cooperative of Puget Sound who were hospitalized for ectopic pregnancy from October 1981 through September 1986 (N = 211). Controls were randomly selected members matched to cases on age and county of residence (N = 457). All subjects in this analysis had had one or more prior pregnancies. Eighty-eight cases (41.7 per cent) and 177 controls (38.7 per cent) had a history of one or more induced abortions. The relative risk of ectopic pregnancy associated with one abortion was 0.9 (95 per cent confidence interval 0.6, 1.3), adjusted for age, county, reference date, religion, gravidity, age at first pregnancy, lifetime number of sexual partners, and miscarriage history. Among women with two or more prior pregnancies, the risk associated with two or more abortions was 1.2 (0.6, 2.4). Controlling for pelvic inflammatory disease and use of intrauterine devices did not alter these risks. We conclude that legal abortion as performed in the US since 1970 has little or no influence on a woman's risk of ectopic pregnancy in subsequent pregnancies.

Abortion, Legal↗

PubMed1988

Family practitioners' immunization consent practice. Washington State, 1986.

Of 400 Washington State family practitioners surveyed in 1986, 46% of those who give routine immunizations reported that they require written parental consent before administering vaccine. In all, 57% of respondents said they discuss diphtheria-tetanus-pertussis, measles-mumps-rubella, and oral polio vaccine with their patients. Nearly half provide written information on these immunizations, except for inactivated polio vaccine, for which fewer than 20% of the physicians surveyed provide verbal or written information.

Consent Forms↗