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V L Ponosov

Publications and source records attributed to V L Ponosov.

6 recordsLinked to original sources
PubMed1991

[Interrelations of cellular and humoral immune response and different doses of sheep erythrocytes in mice].

In experiments on CBA and C57BL/6 mice the generation of antibody-forming cells respectively either in the popliteal lymph nodes or spleen as well as a rate of delayed type hypersensitivity response (DTHR) on the background of subcutaneous (into foot) or intraperitoneal injection of different doses of sheep erythrocytes (from 10(4) to 10(8)) have been studied. In so doing two types of immune response can be isolated on the dependence upon the sensitivity threshold to antigen of DTHR and humoral immunity. Thus in C57BL/6 mice the antigen threshold for DTHR is of one time (in intraperitoneal immunization) or of a two times (in subcutaneous) lower order than for antibody response. In CBA line mice under subcutaneous immunization there can be seen quite an opposite picture while intraperitoneal immunization causes exact correlation of antigen threshold for cellular and humoral immune response.

Animals↗
PubMedDate not supplied

[Iododeoxyuridine metabolism in the oral tissues and its alteration in infection by the herpes simplex virus].

In healthy white rats [125I]-desoxyuridine, [3H]-thymidine, 2-[14C]-uracyl, 8-[14C]-adenine and [3H)-uridine were used to demonstrate that the [125I]-desoxyuridine metabolism in oral mucosa is analogous to that of thymidine and different from metabolic pathways of another nucleoside uridine and nitrogen purine and pyrimidine bases of adenine and uracyl. In rats infected with herpes simplex virus, the relative tissue/blood 123I radioactivity increased after a [125I]-desoxyuridine injection. The authors suggest that the mechanism of [125I]-desoxyuridine action relies on its involvement into the viral host cell DNA.

Adenine↗
PubMedDate not supplied

[Staphylococcus aureus-induced antigen-specific immunosuppression].

In experiments made on noninbred white mice the manifestations of delayed hypersensitivity and the number of antibody-producing cells in regional lymph nodes or the spleen were determined on day 5 after the subcutaneous or intraperitoneal immunization of the animals with sheep red blood cells (SRBC). At the same time the injection of S. aureus antigens simultaneously with SRBC raises the threshold of antigenic sensitivity and decreases the manifestations of cell-mediated and humoral immune response to SRBC. This suppressive effect was even more pronounced in the local immune process and was partially mediated by the hyperproduction of prostaglandins.

Animals↗