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Biomedical subjects

V L Rege

Publications and source records attributed to V L Rege.

12 recordsLinked to original sources
PubMed1978

Treatment of psoriasis: trioxalen and sunlight.

Eighteen psoriasis patients were treated alternately with 40 mg of trioxalen and sunlight on the right side and sunlight only on the left side. Improvement was apparent faster on the psoralen-exposed side.

Adolescent↗
PubMed1977

Dystrophic epidermolysis bullosa. Interesting gastro-intestinal manifestations.

Involvement of the large intestine in a long standing case of dystrophic epidermolysis bullosa was characterized by recurrent episodes of diarrhoea synchronizing with exacerbation of the skin lesions. The radiological investigations revealed two narrow segments, one each in the descending and transverse colon, with ulcer craters in the lower part of the former. The haustra from the distal half of the transverse colon to the sigmoid colon were lost.

Adult↗
PubMed1977

Pattern of reactions in leprosy: a clinical appraisal.

The term 'reactions' is applied in the present text, to describe the acute episodes, recognized with the different types of leprosy. The incidence of reactions was found to be 9.7% of 1053 cases examined. They were seen in all types of leprosy, but their frequency and severity was marked in lepromatous and borderline cases, and in majority of them, the age ranged from 20-40 years. The precipitating factor(s) could not be established in many; in some dapsone was incriminated, followed by bacterial infection and malnutrition. The exacerbations of the existing lesion(s) either alone or in combination with new lesions (E.N.L.) and E.N.L. lesions alone, were the presenting clinical features. The constitutional symptoms were observed largely in the types other than the tuberculoid. Foot drop and contractures of the fingers were the common sequels of the reactions. An attempt has been made to explain their mechanisms in the light of the recent literature.

Acute Disease↗
PubMed1976

Epidemiological and clinical pattern of leprosy in Goa.

A review of 1,053 patients of leprosy revealed its prevalence in the hospital population as 2.4 per thousand. The commonly affected age group was 20-39 in both sexes; males predominating females in 1.8 : 1. The sequence of frequency of clinical types of leprosy was tuberculoid, borderline, neuritic and lepromatous. Mostly the patients report in the course of 2 years of awareness of the disease. The clinical features were classical and type specific.

Adolescent↗
PubMed1976

Epidemiological and clinical patterns of genital lesions.

A 5-year study of 668 patients with genital lesions revealed that teenagers and those in the age group of 20 to 40 are most vunerable. The poor, the uneducated and unmarried persons are at high risk. Chancroid and syphilis are the majority of cases. Inguinal bubo, herpes pregenitalis, condylomata acuminata, erosive balanitis and traumatic ulcers were seen less frequently. Most of the genital lesions had the classic clinical features. The findings of this study suggest that the pattern of genital lesions is showing borderline changes.

Adolescent↗
PubMedDate not supplied

Fixed drug eruptions caused by medications: a report from India.

Fifty-five patients with fixed drug eruption were investigated to determine the drug(s) causing the reaction. History, classic clinical features of well circumscribed erythema, edema and violaceous pigmentation, and the recurrence of the eruptions on the same sites on readministering drug were used as diagnostic criteria. This was confirmed by a provocative test. Sulfonamides and analgesics either alone or in combination were the most common causes of reaction.

Adolescent↗
PubMedDate not supplied

The age of onset of leprosy.

The age of onset was determined in 1,053 consecutive patients having different types of leprosy. There were 675 males and 378 females. The majority had onset of the disease between ages 20 and 39, although all age groups were affected. The age of onset was significantly related to the type of leprosy; the mean was lowest in tuberculoid, highest in neuritic, while in borderline and lepromatous it was in between. The comparison of reports of the age of onset from India and elsewhere suggest that this varies in different regions with the country, and from country to country.

Adolescent↗
PubMedDate not supplied

Correlation between clinical and histopathologic classification in leprosy.

A detailed histopathologic study, utilizing hematoxylin and eosin stain, was done in 95 fresh uncomplicated cases of leprosy. The microscopic features were classified according to Ridley's (1974) definition, while the clinical grouping was done using the criteria of Ridley and Jopling (1962). The disparity between them on comparison was explicit. In one third of the cases the two were in consonance with each other. In many there was a shift of one step either towards the tuberculoid or lepromatous end of the spectrum. The remaining were classified as indeterminate because of early histopathologic changes. This disparity was expected because the parameters used for the histopathologic classification were precise and also took into account the immunologic aspect. The histologic definitions seem practical and may prove useful in assessment of the status of the disease with or without treatment.

Humans↗
PubMedDate not supplied

The prevalence and pattern of leprosy in a school survey.

The prevalence of leprosy in a school survey conducted in Panaji, India was found to be 5.3 per 1,000 with males predominating. The majority of patients had a single lesion on exposed parts of the body showing the clinical characteristics of tuberculoid leprosy. However, clinical features of indeterminate leprosy were seen in two patients and borderline tuberculoid in a single case. On the other hand, histopathologically, the majority of the patients were classified as having borderline tuberculoid or indeterminate leprosy. A disparity between the clinical and histopathologic diagnosis was evident. This observation emphasizes the importance of studying both the clinical and histopathologic features in deciding the precise status of a patient in the leprosy spectrum.

Adolescent↗