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Biomedical subjects

V Lanza

Publications and source records attributed to V Lanza.

29 records · Page 2Linked to original sources
PubMed1984

Influence of cerebral spinal fluid on the affinity of human red cells for oxygen.

The oxygen affinity of washed red cells suspended in their own plasma or in CSF has been studied to demonstrate a possible effect of CSF on the oxygen affinity of human haemoglobin. The CSF was found to reduce the oxygen affinity of haemoglobin significatively, and this was not imputable to the action of pH, PCO2, temperature, 2,3DPG A hypothesis to explain the data found and their clinical interest towards the regulation of brain oxygenation was formulated considering the Monod-Wyman-Changeux model and the effect of solutions on proteins.

Adult↗
PubMed1984

A visual representation of a model for monitoring the state of oxygenation in the critically ill patients. Description and clinical validation.

The authors propose a new circular diagram for monitoring the oxygenation status of critically ill patients. This diagram contains some well known parameters; other ones are suggested to evaluate the pulmonary function and the capability of blood oxygenation. The calculation and a "BASIC" program are provided to use the diagram. This method offers a fast and easy monitoring of oxygenation status by a very small arterious and central venous blood sample.

Humans↗
PubMed1982

Correction of the unfavourable effects of vasopressin by nitroglycerin infusion.

Nitroglycerin was administered with vasopressin to prevent adverse effects. Vasopressin 0.25U . 70 kg-1 min-1 was infused intravenously in four dogs for 40 minutes, when a venous infusion of nitroglycerin 1.2 micrograms . kg-1 . min-1 was added for 20 minutes. Nitroglycerin 1.2 micrograms . kg-1 . min-1 alone was infused intravenously in another four dogs for 40 minutes. The venous blood pressures (mesenteric and central) and arterial pressures (mesenteric and femoral), the electrocardiogram and arterio-venous difference were recorded. Nitroglycerin was shown to annul the unfavourable effects of vasopressin without altering its efficacy upon portal pressure.

Animals↗
PubMed1981

[Variations in blood prolactin in man during enflurane or Alfatésine anesthesias].

Blood prolactin levels (PRL) rise significantly in man following stress or the administration of many drugs. This finding led the authors to study variations in PRL during anaesthesia with Enflurane or Alfatesine. Repeated estimations of PRL were made in 38 subjects: in 8 cases (3 female and 5 male) under anaesthesia with Enflurane only, in 10 cases (6 female and 4 male) with Alfatesine only, in 10 cases (5 female and 5 male) with Enflurane and surgery and in 10 other cases (5 female and 5 male) with Alfatesine with surgery. No significant increase in PRL was seen during the administration of anaesthesia without surgery. By contrast, significant changes were seen when surgery was performed. No significant difference was seen in the results between the two sexes in each group. Taking into account the results of earlier experiments, the authors conclude that Enflurane or Alfatesine alone do not influence the hypothalamo-pituitary axis, but do not protect it during surgical and/or pharmacological stress.

Adult↗
PubMed1980

[Experimental research on hemorrhagic shock in the rabbit. Acid-base equilibrium and survival with 6-methylprednisolone and gelatin administration].

A previously described method was used to induce haemorrhagic shock in the rabbit by removing 40% of the circulating mass. This had been previously established as 2.6 +/- 0.5 kg-1 by a radioisotopic technique. Survivals were determined 1 and 2 weeks later after treatment with 40 mg/kg-1 6-MPD and vascular refilling with 3.5% gelatine equal to the amount removed. The blood gas analysis and EAB findings suggested that haemorrhagic shock includes both a fast and a slow physiopathological stage, and that the results of treatment are strictly linked to the time of its commencement. Metabolic acidaemia and respiratory alkalosis was constant, and all the controls died within 2 days, 6-MPD was not able to normalise the EAB, but ensured 100% survival at 2 weeks. Gelatin brought the lab data close to normal, but only ensured 100% survival at 2 weeks if given immediately after the removal of blood.

Acid-Base Equilibrium↗
PubMed1979

[The neuroendocrine response to Alfatesine or Ethrane anesthesia in humans].

The description of neuro-endocrine effects due to surgical stress and certain anaesthetic products led the authors to look for the action of alfadione and enflurane on the hypothalamic-hypophyseal-thyroidian-adrenal axis. Taking 20 subjects who were divided into three groups of 10, the authors measured the plasma levels of T3, T4, TSH, cortisol and ACTH during anaesthesia with alfadione (without surgery). This was group I. Group II were patients during surgery under alfadione. Group III was during surgery under enflurane. The results show the absence of significant changes in the plasma levels of the hormones measured. The authors conclude that alfadione changes the levels of T3, T4, TSH and cortisol even less than does enflurane, whether the anaesthesia is isolated or in a patient undergoing surgery.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[Importance of an outpatient record in obstetric anesthesia].

A computerised record was used to collect data following an anesthesiological check-up of pregnant women at approximately 30 weeks of pregnancy. The record was input onto a portable PC in the anesthesia outpatient clinic, memorized on disk (3.5") and then transferred onto a PC network (one PC for each operating theatre) for "real time" consultation of each patient's data. All pregnant women attending the antenatal clinico were also given a folder illustrating epidural anesthetic techniques. Seven hundred and nine outpatient visits have been performed over the past two years with a 62% utilisation ratio. The collection of data using a computerised system allows a rapid and efficacious system of communication to be set up among the membranes of the anesthesiological team, thus encouraging the use of epidural techniques during labour. The distribution of the folder also facilitated the task of the anesthetist who found that pregnant women visiting the anesthesia clinic were already familiar with the epidural technique.

Anesthesia, Epidural↗
PubMedDate not supplied

[Blood level of thyroid hormones in surgical thyroid diseases. Pre-,intra- and post-operative T3 and T4 levels].

A pre-, intra- and post-operative determination of thyroid hormone in values in the peripheral and thyroid vein reflux blood of patients with thyroid disorders requiring surgery showed that the so-called intraoperative squeezing of the gland either does not place or is of little importance when delicate surgical movements are commenced. A low incidence of intraoperative arrhythmia was also noted. Prevention of the latter is not indicated, since it is often dependent on surgical movements and/or unorthodox anaesthesiological management.

Adolescent↗
PubMedDate not supplied

[The use of dobutamine during the intraoperative period to prevent organ hypoperfusion in non-heart surgery. Administration modality and monitoring].

Dobutamine is strongly recommended in the treatment of critical intensive care patients in order to improve cardiac performance and peripheral perfusion. In non-cardiac surgery there are frequent cases of organ hypoperfusion that could be treated with dobutamine; the drug, however, is not advocated since it is difficult to control without invasive hemodynamic monitoring. This study analyzed the possibilities of using and controlling dobutamine in non-cardiac surgery. The study covered 186 patients ranging from 40 to 80 years of age who were divided into two groups according to ASA class and the type of surgery they were to undergo (Group I ASA 1-2 major surgery, group 2 ASA 3-4 standard and major surgery). Of these, 93 patients were treated with dobutamine infusion, 3 mu/kg/min, started before anesthesia and modulated for the duration of the operation on the basis of the patient's monitoring values. The remaining 93 patients were the controls who underwent the same anesthesiological procedure without receiving the drug. During anesthesia we monitored: mean blood pressure, pulsioxiometry, fraction of exhaled CO2 and heart rate. Analyses were done using a personal computer network connected to the patient monitoring system. For each parameter we calculated the number of times per hour of anesthesia that different readings were taken (higher or lower) with respect to the value recorded immediately after premedication. The following variations were considered significant. 5 mmHg for blood pressure, 10 b/min for heart rate, 4% higher or lower for exhaled CO2; plus or minus 95% for pulsioximetry. The data were evaluated using the chi 2 test. The treated patients showed significantly higher blood pressure, exhaled CO2 and heart rate values, demonstrating that dobutamine infusion can be piloted on the basis of these monitoring parameters. The treated patients had 4% higher exhaled CO2 levels showing the close correlation between exhaled CO2 and the use of the inotrope. The overall results show that dobutamine is easy to use and readily piloted during anesthesia for non-cardiac surgery.

Adult↗