The glucagonoma syndrome--report of a case without overt diabetes.
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Biomedical subjects
Publications and source records attributed to V Leibovici.
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Sweet's syndrome (acute neutrophilic dermatosis) is characterized by fever; polymorphonuclear neutrophilic leukocytosis; elevated ESR; and characteristic, raised, painful red plaques on the face and limbs. Since Sweet first described the syndrome in 1964, more than 150 cases have been reported, but it is assumed that the disorder is far more common than this number would indicate.
Pilot measurements were made of natural UV radiation (UVA and UVB, broad-band and erythemogenic) on the Dead Sea (400 m below sea level) and in Spain at sea level, both at approximately the same geographical latitude. Measurements were made at different times of single days during the 1985/1986 season. The preponderance of UVA over UVB was more pronounced in winter.
Local hyperthermia induced by ultrasound was delivered two or three times weekly to twenty-eight lesions of acute cutaneous leishmaniasis in eighteen patients. Twenty-two lesions (78.5 percent) in thirteen patients resolved completely five to ten weeks after the start of treatment. Our results are explained by the thermosensitivity of the parasite and its inability to survive at supranormal temperatures. Ultrasound hyperthermia was tolerated by most of the patients. The results of this study indicate that topical heat is safe and effective for the treatment of patients with acute cutaneous leishmaniasis.
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Fourteen patients with acute cutaneous leishmaniasis entered a study testing the efficacy of liquid nitrogen. All lesions were cured clinically and protozoologically within 3-8 weeks, without noticeable scarring. The patients did not experience adverse side effects, and there was no relapse 4 months after cessation of therapy. The results of this study indicate that cryotherapy is a safe and effective method for treating cutaneous leishmaniasis.
A 62-year-old woman with an 8-year history of urticaria, arthralgia and arthritis developed recurrent pleural effusion. A thorough laboratory workup during repeated attacks of concomitant urticaria and pleural effusion disclosed only hypocomplementemia and the histopathological finding of the skin biopsy revealed leukoclastic vasculitis. These findings are compatible with the entity of urticarial vasculitis. It is thus suggested that pleural effusion can form part of the systemic manifestations of urticarial vasculitis.
A case of glucagonoma where repeated gastrointestinal examinations revealed excessive mucosal fold thickening of the duodenum and small bowel with a markedly delayed transit time is reported. These findings in the appropriate clinical setting led us to persevere with further investigations despite equivocal ultrasound and CT examinations. We wish to emphasize the importance of the classical gastrointestinal findings in the diagnosis of the glucagonoma syndrome.
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