Comparison between gammagraphy and roentgenography.
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Biomedical subjects
Publications and source records attributed to V Lopez-Majano.
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Until recently, the diagnosis of primary neoplasms and metastasis required different and complicated tests, many of which were invasive. Several radiopharmaceuticals have been tried in the diagnosis and management of neoplasms, but so far, the only radiopharmaceutical which gives satisfactory results is Gallium 67. Scintigraphy with this compound allows localization of the primary neoplasm and metastasis. It is also useful in the staging and follow-up and, in particular, in ascertaining the efficacy of treatment. Gallium scintigraphy is a very sensitive procedure, but not very specific; active inflammatory processes can produce an abnormal localization of the Gallium 67 in the infected area.
Scintigraphy, the visual display of radioactivity, shows the size, shape and structure of the organ being studied. This information should be complemented with dynamic studies which will indicate the distribution of the radioactivity in the organ in relation to time. Dynamic studies must be performed with external detectors and the gamma camera. Circulation (systemic, pulmonary or cerebrospinal fluid) can be studied depending on the method of administration and the radionuclide used. The indicators are the same as for arteriography. Regional distribution of ventilation can be studied using radioactive gases. Regional distribution of ventilation of the lungs and mucociliary clearance can also be studied using inhaled particles. Dynamic studies do not replace but only supplement scintigraphy. They should be quantitated to obtain objective information.