PubMed Health⌕ Search

Biomedical subjects

V Luci

Publications and source records attributed to V Luci.

7 recordsLinked to original sources
PubMed1983

[Dialysis osteopathy with spontaneous fractures, progressive demineralization and therapy resistance].

In 25 (33.8%) of 74 chronically haemodialysed patients a distinct osteopathy with bone pain, spontaneous fractures, arthralgias and weakness of the muscles due to dialysis was present. In comparison to a group without complaints the duration of the dialysis was longer by 6 months, the mineral contents of the bones was decreased in 38%, in the comparative group in 22%. A progressive demineralisation was found in 46%, in the comparative group in 20%. Hypercalcaemias under vitamin D2 caused a therapy resistance. In 1 exemplary case (type IIc, PTH 0.3 micrograms/l) in the 3rd year of dialysis a fracture of the neck of the femur took place and an endoprosthesis was implanted. There was a progressive demineralisation of about 16%. The suspicion of a typical combination with an encephalopathy due to dialysis did not confirm itself. A pseudocyst in the brain was found. The differential diagnosis to the hypercalcaemia-induced psychosis in the osteopathy due to dialysis is discussed. In a prophylactic application dihydrotachysterine proved favourable for avoidance of an osteopathy due to dialysis. Parallel to the clinical progressing of the osteopathy due to dialysis a progressive demineralisation could be demonstrated at the peripheral mineral contents of the bones. Extreme losses of minerals appeared from the 4th to the 59th month of dialysis from - 16% to - 37% and from the 22nd to the 87th month from plus 11% to minus 14% of the age-and-sex-specific normal values. Successful transplantations led to the stagnation of the progressive demineralisation, unsucessful transplantations increase them. The influence of the non-refined water for the production of dialysate by possible aluminium intoxications on the development of the osteopathy due to dialysis is discussed.

Aluminum Hydroxide↗
PubMed1983

[Behavior of important serum lipid fractions in chronic hemodialysis patients and following kidney transplantation].

In patients in the chronic programme of haemodialysis and 51 patients with transplanted kidney selected lipid-chemical parameters were investigated and compared. 1. Disturbances of the lipid metabolism more frequently occurred in patients with transplanted kidney than in chronically haemodialyzed patients. 2. Triglycerides, total cholesterol and LDL cholesterol were more frequently increased in patients with transplanted kidney than in chronically haemodialysed patients. 3. The HDL cholesterol of patients with transplanted kidney was only somewhat higher in comparison to patients in the chronic haemodialysis programme. 4. Sex-specific differences of the HDL cholesterol level were neither in chronically haemodialysed patients nor in patients with transplanted kidney. 5. Klimov-index and LDL/HDL cholesterol quotient referred to a permanently high risk of cardiovascular complications even after transplantation of a kidney.

Adolescent↗
PubMed1983

[Oxygen exchange processes between the dialyzing fluid and the blood during hemodialysis and resultant practical consequences].

The polarographic measuring technique was used to examine the processes of oxygen exchange between dialysing fluid and blood during haemodialysis in 21 patients of the chronic haemodialysis programme. During haemodialysis there is a tendency for the arterial oxygen partial pressure to fall; on the statistical average this is slight, in individual cases it is a marked tendency. With the apparatus KNA 302 (without degassing facilities) the blood is slightly oxygenated. This is less with the apparatus KN 401 (not very effective degassing facilities). With complete degassing of the dialysis solution a loss of oxygen through the membrane would be expected. This loss could be avoided by complete degassing of the dialysis solution and subsequent oxygenation. Various ways of realizing extrapulmonary oxygenation during haemodialysis in order to counteract the described tendency to hypoxaemia are pointed out. They should be particularly important when pulmonary means are exhausted (acute dialysis, shock lung).

Adult↗
PubMed1982

[The problem of sodium metabolism in chronic kidney failure].

The endogenous 24-hour-clearance and the sodium excretion during 24 hours in the urine were investigated on 12 healthy persons with chronic nephropathies, 5 patients with condition after acute renal failure and 75 patients with condition after transplantation of a kidney. A correlation between the quantity of urine and the excretion of sodium in 24 hours could be proved in patients with a retention to 884.0 mumol/l creatinine in the serum. Only with further restriction of the renal function a reduction of the sodium excretion during 24 hours below 150 mmol becomes significant. In 16 of 25 patients in the early phase of the again occurring renal function after transplantation the sodium excretion more rapidly improved than the creatinine clearance. In 20 patients with chronic crises of rejection in 15 cases the creatinine clearance and the sodium excretion simultaneously decreased. In one patient the rejection began with a reduction of the sodium excretion.

Animals↗
PubMed1980

[The kidney and diuretics].

In an experiment carried out on 5 awake dogs with different size of the kidney could be shown that the diuretic effect of the xanthines is only slight and depends on the number of nephrons got. The application of thiazides, which possess a long-term effect, is indicated only up to a value of the creatinine clearance of about 25 ml/min/1.73 m2. At the beginning retention of the substances contained in the urine furosemide can still be used in high doses. In 18 patients with values of serum creatinine between 2-20 mg/100 ml also with a dosage up to 500 mg furosemide within 24 hours the Na+-concentration in the urine did not exceed a value of 90 mval/l. These findings are explained in the sense of the proof of a limit of the possibilities of a conservative treatment of the chronic renal insufficiency with furosemide.

Benzothiadiazines↗
PubMed1979

[Differential diagnosis and therapy of nephrogenic hemorrhagic diathesis].

For the development of nephrogenic haemorrhagic diatheses in the first place a decreased function of the thrombocytes and a thrombocytopenia are responsible. An inhibition in the intrinsic system may be referred to a lesion of the thrombocytic factor 3. Up to now defects in the extrinsic system do not allow a systematic classification. The best causal therapy are an effective haemodialysis and a renal transplantation. The detection of defects in the coagulation system is of importance for the dosed heparinisation and the control of the treatment with cytostatics for the immune suppression. Among 33 patients undergoing dialysis only 3 patients the Quick-value was reduced to 50% in 9 patients the thrombocyte values were below 150,000 mm3 and in 2 patients below 100,000 mm3. Among 28 carriers with renal graft only in 1 case the Quick-value was reduced to about 50%. In 12 patients the thrombocyte values were decreased below 150,000 mm3 and in 4 patients below 100,000 mm3. A correlation between the two global tests was not to be proved.

Adult↗