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Biomedical subjects

V M Bykov

Publications and source records attributed to V M Bykov.

17 recordsLinked to original sources
PubMed1992

[Surgical-drug therapy aspects of the treatment of patients with obliterating thromboangiitis of the lower limbs].

Standard operative interventions (thromboendarterectomy, (autovenous shunt) in patients with thromboangiitis obliterans of the lower limbs produce a poor effect. This is explained both by a poor initial condition of the draining channels and by advancement of the primary thromboangitic affection of the vascular wall in the zone of the intervention with its development into a stenotic-occlusive process. The use of some technical (operative) innovations, particularly postoperative arterial infusion of suspended forms of immunosuppresive agents (hydrocortisone, Kenalog), increased essentially the efficacy of restorative operations on the vessels with a high level of limb preservation and patency of the vessels which had been operated on.

Adult↗
PubMed1990

[Long-term regional (catheter) infusion of anticoagulants and thrombolytics in the treatment of acute and chronic arterial occlusions in patients with thromboangiitis obliterans with severe ischemia of the limbs].

Catheter heparin therapy combined with the intraarterial infusion of microcrystalline suspensions of antiinflammatory and immunosuppressive agents did not provide elimination of the microcirculation block in the affected limbs of the patients with severe ischemia of the limbs. Thrombolytics used in acute and chronic thromboses in most of cases did not help in complete recanalization of the arteries. Regional thrombolysis conducted before the basic course of the arterial infusion (heparin + immunosuppressants) in patients with distal forms of the arterial affections, promoted a significant improvement of conditions of the regional microcirculation. Application of this method has permitted lowering the rate of limb amputations.

Anticoagulants↗
PubMed1990

[Regional drug microemboli in the treatment of patients with thromboangiitis obliterans of the lower extremities].

The authors analysed the immediate and late-term results of treatment of 351 patients with thromboangiitis++ obliterans of the lower limbs by regional intraarterial infusion with the use of microcrystal line suspensions of hydrocortisone, oxytetracycline, and zinc-insulin. The method is shown to be highly effective in patients with affection of the distal arterial bed. A stable remission in the late-term period was attained in 80.4% of the patients.

Adolescent↗
PubMed1989

[Disorders of the system of regulation of the aggregative status of the blood in patients with thromboangiitis obliterans of the lower extremities].

Predominantly regional disorders of blood aggregation control, aggravating with the progress of ischemia, were detected in patients with obliterating thromboangiitis of the legs. Local overstrain and exhaustion of compensatory anticoagulation and thrombolytic factors developed in the presence of critical ischemia of the limbs and were accompanied by developing regional prethrombotic state. Regional administration (intra-arterial infusions) of anticoagulants and thrombolytic agents appears to be the most justified line of remedial therapy in these patients.

Adolescent↗
PubMed1989

[Effect of lumbar sympathectomy on orthostatic reactivity of the arteries of the extremities in thromboangiitis obliterans].

Lumbar sympathectomy in majority of patients with thromboangiitis was found to be followed by a reduced pathogenetically reliable orthostatic and post-orthostatic++ spasm of the diseased arteries. Patients with persistent and continuous remission had normo- and hypotonic orthostatic reaction of the extremity vessels. Remote clinical results of the intervention on lumbar sympathetic ganglia were dependent on the degree of correction of local angiotonic and angiospastic disorders.

Adolescent↗
PubMed1987

[Regional orthostatic hypertension and thromboangiitis of the lower extremities].

A study of local orthostatic disorders of pulse blood filling, microcirculation and acid-base state in the affected limbs of 84 patients with thrombo-angiitis has suggested that local orthostatic distal vascular hypertension in the lower limbs, along with subsequent vascular tissue metabolic and coagulation response, conditions preferential development and progress of spastic, ischemic and thrombotic manifestations of the disease.

Acid-Base Equilibrium↗
PubMed1985

[Features of the structure of arteries of the lower extremities in man].

A comparative investigation has been performed on structural peculiarities of muscle arteries having various caliber in the lower extremities and in the anterior thoracic wall (section material, 40 observations). An essential predominance of the muscle tunic thickness and deterioration of blood supply has been stated in the arterial wall and in the distal parts of the lower extremities. The structural peculiarities revealed in the arteries of the extremities are connected with functional conditions of blood supply in the zone at the vertical position of the human body (orthostatic arterial hypertension).

Arteries↗