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Biomedical subjects

V M Ferguson

Publications and source records attributed to V M Ferguson.

6 recordsLinked to original sources
PubMed1999

Per-operative retinoscopy as a predictor of final post-operative refraction.

PURPOSE: To assess the accuracy of streak retinoscopy performed at the end of cataract surgery as a predictor of final post-operative error. METHOD: Retinoscopy was performed on 68 patients as they lay on the operating table after routine cataract extraction and intraocular lens implantation. In each case the predicted post-operative refraction by biometry and the retinoscopy at the end of the operation were compared with the 6 week post-operative subjective refraction. RESULTS: The retinoscopy had a mean difference of 0.6 D (standard deviation of 0.5 D). The post-operative refraction predicted by biometric measurements had a mean difference of 1.6 D (standard deviation 0.6 D). When corrected for systematic error, 8% of patients were found to have an error of greater than 2 D as predicted by pre-operative biometry. Prediction by retinoscopy made no error greater than 2 D. The accuracy in the retinoscopic prediction of post-operative refraction was significantly better than the biometry using the F-test (p = 0.001). CONCLUSION: Retinoscopy at the end of cataract surgery may be a valuable tool to alert the surgeon to an unexpected refractive error. This would enable immediate intraocular lens exchange, if required.

Biometry↗
PubMed1997

Corneal infiltration after recurrent corneal epithelial erosion.

AIMS: To describe the clinical features of patients with a history of recurrent corneal epithelial erosion who develop acute corneal infiltration. METHODS: The records were reviewed of patients who had previously been examined and treated for recurrent corneal epithelial erosion and who presented again with signs suggestive of a microbial keratitis. RESULTS: 11 patients were described; one patient presented with similar signs on two occasions. There was typically a paracentral epithelial defect > 2 mm in diameter with an associated stromal infiltrate and an intense anterior uveitis. Three patients had a hypopyon, and four developed a subepithelial ring infiltrate. Samples were taken for microscopy and bacterial culture, with a positive isolate from two of 12 episodes (16%). Treatment with topical antibiotics and topical corticosteroid resulted in rapid re-epithelialisation and a reduction of inflammation. There was good visual outcome for all eyes, with a recurrence or symptoms of epithelial erosion in only one eye after a mean follow up period of 18 months. CONCLUSIONS: Corneal infiltrates are an uncommon complication of recurrent corneal epithelial erosion. Despite the intensity of the infiltration the majority are culture negative using established techniques. There is typically rapid resolution and a good visual outcome, with a tendency for the episode to mark the end of further symptoms of epithelial erosion.

Adrenal Cortex Hormones↗
PubMed1992

Quantification of the ocular response to treatment in posterior uveitis.

Twenty patients with posterior uveitis were studied by anterior segment fluorophotometry to determine whether there was a relationship between the degree of breakdown of the blood-aqueous barrier and the clinical recovery of posterior uveitis. In individual eyes the degree of breakdown and recovery of the blood-aqueous barrier (as measured by changes in the anterior chamber fluorescein concentration) followed the resolution and relapse of disease making it possible to quantify the ocular response to treatment.

Adult↗
PubMed1992

Continued breakdown of the blood aqueous barrier following cataract surgery.

Following routine extracapsular cataract and posterior chamber implant surgery, recovery of the blood aqueous barrier (BAB) was quantified by sequential anterior chamber fluorophotometry. This was correlated with surgical details and postoperative findings to ascertain those factors which were related to excessive damage of the BAB immediately after surgery and to failure to recover a normal BAB by 3 months postoperatively. A cohort of 84 patients was followed. In the early postoperative period excessive levels of damage to the BAB were related to iris damage (p < 0.01) and diabetes mellitus (p < 0.01). By 3 months, 79% of the eyes had recovered normal BABs and 21% (18 eyes) had persisting excessive fluorescence which correlated with an abnormal pupil shape (p < 0.02) and the development of posterior synechiae (p < 0.001).

Adult↗
PubMed1991

Recovery of the blood-aqueous barrier after cataract surgery.

Following extracapsular cataract and posterior chamber implant surgery the sequential recovery of the blood-aqueous barrier was measured by anterior segment fluorophotometry. Postoperatively 49 (69.0%) out of 71 eyes (71 patients) had recovered at a uniform rate, re-establishing a normal blood-aqueous barrier by the end of the three-month study. In these eyes recovery of the blood-aqueous barrier was unaffected by the use of preoperative indomethacin, the surgeon, the type of section, or the type of fixation of the implant. In eyes recovering normally after cataract surgery the rate of recovery of the blood-aqueous barrier can be expressed by a in the equation a = (y-b)/x, in which y is the logarithm of the anterior chamber fluorescence, x is the time after surgery, and b is a constant for each patient which is the anterior chamber fluorescence measured immediately after surgery. This normal rate of recovery provides a baseline from which to assess surgical technique or postoperative medication.

Adult↗