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V M Getsova

Publications and source records attributed to V M Getsova.

18 recordsLinked to original sources
PubMed1987

[Changes in the content of water-soluble brain proteins-antigens during bilateral avoidance training of rats].

The levels of water-soluble brain antigens have been studied during bilateral avoidance learning in Wistar rats. With the help of cross and rocket immunoelectrophoresis the content of antigens was measured in the brain structures an hour and a week after training. It was shown that the content of one of six antigens in the auditory cortex correlated with the number of tone-shock combinations. The antigen was not found in the liver and its amount was higher in the brain stem, as compared to cerebral cortex and cerebellum. The results suggest that this antigen may be involved in the processes of memory build-up.

Acoustic Stimulation↗
PubMed1976

Relationship between the peculiarities of elaboration and retention of brightness discrimination and the serotonin content in the rat brain.

The role of serotonin in memory consolidation was investigated by comparing the serotonin content in the brain of young and old animals which differed in the duration of consolidation process and by comparing the serotonin content in the brain with the efficiency of retrieval of memory traces in animals of the same age. Old rats had the serotonin content higher in the hippocampus and lower in the hemispheres, diencephalon, midbrain and medulla as compared with young ones. Elaboration of brightness discrimination increased the brain serotonin content in old animals and decreased it in young ones. Inverse correlation occurred between the serotonin content in the hippocampus, midbrain and the medulla and retention of conditioned reflexes in rats of the same age. No correlation occurred between the serotonin content in the cerebral structures and the rate of conditioning.

Age Factors↗
PubMedDate not supplied

Content of norepinephrine and serotonin in symmetrical divisions of the brain of rats in the norm during learning and with the administration of peptides.

The content of norepinephrine (NE) and serotonin (5-HT) in the right and left halves of the brain of rats was compared in the norm, during the development of defensive two-way avoidance conditioned reflexes (TWACR), and with the administration of peptides which influence learning and memory, namely desglycine-arginine vasopressin (DG-AVP), ACTH4-7 pro-gly-pro, and dalargin. These investigations demonstrated that the content of NE in the right cerebral hemisphere is significantly higher than in the cortex of the left. Significant differences were not detected with respect to the 5-HT content in symmetrical parts of the brain. The asymmetry of the NE content was eliminated under the influence of the development of the TWACR. The systemic administration of DG-AVP, ACTH4-7 pro-gly-pro, and dalargin essentially did not alter the 5-HT content, and decreased the NE content in the cortex and in the rest of the brain. In the process the NE content of the right and left hemisphere evened out. The data obtained point to the asymmetrical character of the action of the neuropeptides and to the greater resistance of the serotoninergic system of the brain to a functional load and the administration of peptides by comparison with the noradrenergic system.

Animals↗
PubMedDate not supplied

[Effect of an excess of serotonin in the brain on consolidation of temporary connections].

As a result of intravenous administration of 100 mg/kg of 5-oxytryptophane (5-OTP) to mice, the serotonin content in the brain rises in ten minutes by 35 to 37 per cent, and in an hour, by 58 to 60 per cent, and declines in a day to its initial level. In case of elaboration of passive avoidance reflexes (PAR) an hour after 5-OTP injection, their preservation considerably decreases in a day's time, while 5-OTP administration immediately following PARs elaboration does not affect their preservation. However, 5-OTP injected after PARs elaboration to animals subjected to preliminary cooling, sharply deteriorates their preservation. These facts in conjunction with the previously obtained date attest that excess of serotonin in the brain has a negative effect on the earliest stages of consolidation. When the animals are cooled and the brain temperature is reduced, the consolidation processes are retarded; as a result, the temporary connections prove to be still vulnerable to the action of serotonin excess set up after PAR elaboration.

5-Hydroxytryptophan↗
PubMedDate not supplied

[The effect of monoamine oxidase inhibition on formation, fixation and reproduction of temporary connections].

An administration of 100 to 300 mg/kg doses of iprazid to rats and mice leads in 24 hours to a considerably higher serotonin and noradrenaline content in the brain. Defensive conditioning against this background proceeds in the same way as in control animals but the retention of elaborated reflexes is sharply disturbed. A similar effect is produced by 5-oxytryptophane. An iprazid administration after conditioning does not disturb the retention and subsequent achievement of the reflex. Inclusion of S35-methionine in the total proteins of the mice brain does not change under the influence of iprazid. A conclusion has been drawn that inhibition of monoaminoxidase by iprazid does not prevent the formation and reproduction of temporary connections, but deeply disturbs their fixation. It is suggested that the revealed disturbances of fixation of temporary connections are due to the accumulation of serotonin in the brain, which suppresses the protein synthesis in the synaptosomes or that of specific proteins.

Animals↗
PubMedDate not supplied

[Effect of a decrease in the concentration of serotonin in the brain on elaboration and preservation of defensive conditioned reflexes].

Injection of a total dose of 1200 mg/kg of parachlorphenylalanine to mice leads to a 75% drop in the serotonin (5-OT) content in the brain with a subsequent return to the initial level in seven days. The processes of elaboration and reproduction of conditioned defensive active and "passive" avoidance reflexes were studied against the background of reduced 5-OT content. It has been assumed that the observed disturbances in elaboration are linked to the increased fear emotion when the mice are placed in new surroundings. Disturbances in retention of the "passive" avoidance conditioned reflex are in fact disturbances of its reproduction. A conclusion has been drawn that a drop in the 5-OT content in the brain does not prevent the formation and fixation of defensive temporary connections.

Animals↗
PubMedDate not supplied

[Effect of serotonin on processes of elaboration and fixation of heterogeneous temporary connections].

The effect of serotonin (5-OT) level in the brain on the elaboration and retention of heterogenous conditioned reflexes was studied in the experiments on rats and mice. Redundancy of 5-OT deteriorated the retention of defensive and alimentary conditioned reflexes and almost fully prevented the fixation of drinking conditioned reflexes. The reduction of 5-OT led to less pronounced disorders in the retention of conditioned reflexes. With a prolonged delay of electrocutaneous reinforcement (from 5 to 10 s) the control animals showed slower elaboration of two-side avoidance reflexes, while their retention was uneffected. The redundancy of 5-OT in these conditions accelerated the elaboration but at the same time deteriorated the retention as in case of 5-second delay. A conclusion is made that with the changed level of 5-OT the impairment of conditioned reflexes retention doesn't depend on the changes in the speed of their elaboration. The "point of application" of changes in 5-OT content lies in the process of the temporary connection consolidation. The degree of 5-OT participation in these processes depends on the characteristics of elaborated conditioned reflexes.

Animals↗
PubMedDate not supplied

[Effect of a decrease in brain noradrenaline and serotonin levels on defensive and food-getting conditioned reflexes in rats].

The influence of pharmacological and surgical interferences in the activity of serotoninergic and catecholaminergic brain systems on elaboration and consolidation of conditioned reflexes was studied in rats. Ablation of the locus coeruleus, nucleus raphe and administration of inhibitors of monoamines synthesis reduced noradrenaline and serotonin (5-OT) content in rat's brain. Ablation of the locus coeruleus and disulphiram administration impaired mainly the elaboration of defensive and alimentary conditioned reflexes. Ablation of the nucleus raphe and parachlorphenilalanin administration affected predominantly the retention of the reflexes. At the same time, the effects of surgical and pharmacological interferences differed in some respects

Animals↗
PubMedDate not supplied

[The noradrenaline and serotonin content in symmetrical parts of the normal rat brain and during learning and peptide administration].

Content was compared of noradrenaline (NA) and serotonine (5-OT) in the right and left halves of the rats brain in norm, at elaboration of defensive conditioned reflexes of two-ways avoidance (CRTWA) and at administration of neuropeptides influencing the learning and memory--dezglycilargininvasopressin (DG-AVP), ACTH4-7 pro-gli-pro and dalargin. The conducted studies showed that in control animals the content of NA in the cortex of the right hemisphere was significantly higher than in the cortex of the left one. For the content of 5-OT in symmetric brain parts no significant differences were revealed. Under the elaboration of CRTWA the asymmetry of NA content was not eliminated. Systemic administration of DG-AVP, ACTG4-7 pro-gli-pro and dalargin practically did not change the content of 5-OT, but reduced the content of NA in the cortex and the rest of the brain, and the content of NA in the right and left cortex was equalized. The obtained data point to the asymmetric character of neuropeptides action and to greater resistance of 5-OT-ergic brain system to functional load and to administration of peptides in comparison with NA-ergic system.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[Serotonin excess in the brain modifies the effect of beta-endorphin and dalargin on the processes of learning and memory].

In experiments on outbred female rats the influence was studied and compared of two representatives of endogenous opioids beta-endorphine and the analogue of leu-enkephalin dalargin on the processes of learning and memory in normal conditions and at the change of functional state of serotoninergic system of the brain. Parallel, the influence was studied of neuropeptides on the content of serotonin (5-OT) and its metabolite--5-oxyindolacetic acid in various areas of the brain in control and at the 5-OT redundancy. Conditioned reflexes (CRs) were used of two-way avoidance and defensive CRs. It has been established that administration of neuropeptides to intact animals influences in different directions the elaboration of the CR of two-way avoidance and maze defensive CR, but also worsens their preservation. Redundancy of 5-OT in the brain modifies behavioural effects of beta-endorphine and dalargin manifested in appearance of new effect and elimination and change of direction of the effects observed in the intact animals. Redundancy of 5-OT in the brain changes metabolic effects of beta-endorphine and particularly of dalargin. The obtained data testify to a dependence of the effects of beta-endorphine and dalargin on the functional state of 5-OT-ergic system.

Animals↗
PubMedDate not supplied

[Effect an ACTH analog on the processes of learning and memory in rats].

On the basis of the idea of the important role of neurotransmitter systems in realization of neuropeptide effects, the participation was studied of the monoaminergic systems in the mechanisms of the ACTH analogue influence on the processes of learning and memory in control animals and animals with a changed functional state of the monoaminergic systems. In parallel the influence was studied of the ACTH analogue on the content of the endogenic monoamines in various brain structures of rats. It has been shown that administration of the ACTH analogue in a dose of 10 mcg affects the elaboration and preservation of conditioned reflexes (CRs) of passive avoidance, CRs of two-side avoidance and labyrinth CRs only in conditions of changed functional state of the monoaminergic systems. Amnesia, usually elicited by 5-oxytryptophane and disulfiram is prevented by administration of the ACTH analogue. Administration of the ACTH analogue is accompanied by the intensification of serotonine metabolism in the midbrain and medulla and by an increase of noradrenaline content in the hypothlamus.

5-Hydroxytryptophan↗
PubMedDate not supplied

[Effect of a cyclic analog of enkephalin on learning and memory in the mouse].

In experiments on mice, the effect of cyclic analogue of enkephalin (CAE) on the processes of learning and memory was studied in control animals and in animals with changed functional state of monoaminergic brain systems. Administration of the peptide to intact animals significantly accelerated the acquisition of conditioned reflexes of two-way avoidance and did not significantly affect the retention of these reflexes and their subsequent reproduction. Retention and reproduction of conditioned reflexes elaborated in one combination, was disturbed. Administration of iprazid did not eliminate the "accelerating effect" of CAE on the formation of conditioned reflexes of the two-way avoidance but sharply disturbed their retention. In such conditions, the amnesing iprazid effect increased still more. Besides, under CAE effect, the activity of acetylcholinesterase in the motor and especially in the visual cortex of the mice increased. The obtained data testify to an important role of the monoaminergic and cholinergic brain mechanisms in realization of CAE effects on the processes of learning and memory.

Acetylcholinesterase↗