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Biomedical subjects

V M Khaiutin

Publications and source records attributed to V M Khaiutin.

At least 19 recordsLinked to original sources

[Computer cardiokymography. On its way to long-term noninvasive monitoring of cardiac performance in daly life].

A functioning heart generates low-frequency and low-amplitude movements (up to 40 (mrn) of soft tissues in the percardial area. Since the 1950-s of the XX-th century cardiologists have studied these movements to employ them in the diagnostics of ischemic heart disease (IHD). Indeed, changes of the movements have found their diagnostic application in this field. If blood supply to a certain area of ventricular myocardium is insufficient the contractions in this area diminish and even ceases. After systolic increase in ventricular pressure this area dilates and forces intercostal tissues out, causing a "bulge" wave on the record. For recording the patient must be in supine position and hold the breath. High frequency electromagnetic field generator was used in an attempt to examine the heart movements. It was found that such instrument measures the thickness of the air-gap that serves as a dielectric or a "capacitor" which forms between the skin and approaching it flat inductive coil. Nevertheless, such an instrument (cardiokymograph, CKG) can reveal changes in contractions of ischemic myocardium and markedly increases the sensitivity of the exercise ECG test. However, CKG can be recorded only after termination of the test. This principal disadvantage has been overcome by software that allowed the recording of CKG during the test. A low-frequency capacitance transducer developed recently by Chinese researchers has provided a simultaneous recording of several CKG. After modifying the transducer, we have established that 1) the shape of CKGs is the same as that CKGs recorded by all our predecessors, 2) CKGs are reproducible even within a 3-month interval, 3) the enormous mechanical interference caused by respiratory movements and, to a greater extent, by the vigorous movements of the legs and trunk during veloergometry can be eliminated by digital processing of the transducer signals, and 4) pathological changes appear in CKG of patients with IHD, which enables one to stop veloergometry at lower loads, thus increasing the safety of the test. Since for large medical insurance companies very simple and inexpensive cardiokymograph are quite unprofitable, their commercially production in USA and in Germany has been stopped. However, the goal of cardiokymography: a real-time, beat-to-beat, long-term monitoring of cardiac function in daily life, remains the major factor determining the future of the method.

Computers↗

[The regulation of the lumen of the major arteries in accordance with the shear stress on the endothelium].

A decrease in the blood viscosity due to hemoconcentration, caused arterial dilatation. These viscosity-induced responses depended on intact endothelium. The dilatory responses caused by equal increments in flow rate, increased in systemic hemoconcentration and decreased in systemic hemodilution. The data obtained corroborate the suggestion that stress applied to endothelium is the key signal in the control of arterial lumen by the blood flow rate.

Animals↗

[Nitrogen oxide is not an agent of endothelium-mediated arterial dilatation to an increase in the blood flow rate].

I. v. administration of inhibitors of endothelium-mediated synthesis of the oxide of nitrogen raised the arterial blood pressure, constricted the femoral artery and decreased the acetylcholine- and ATP-induced vaso-dilatation in anesthetized cats. However, the dilatation induced by an increased blood flow velocity, was not affected. The data obtained suggest that the endothelium-dependent arterial dilatation is not mediated by oxide of nitrogen formed from L-arginine.

Acetylcholine↗

[An experimental verification of the histomechanical theory of the working hyperemia of the skeletal muscles: biomicroscopic research].

The histomechanical hypothesis of working hyperemia in skeletal muscle was verified by comparison of the dynamics and values of frog submaxillary muscle arterioles dilation under: 1) 4-Hz twitch contraction and 2) imitation of mechanical component of the twitch contractions. Deformation of arterioles occurred during incomplete tetanus with the maximal effect at the peaks of twitches. The repetitive displacements of a small bunch of muscle fibers with the frequency of 4 Hz and the amplitude of 0.05 to 0.25 mm caused a dilation of the arterioles attached to the fibers. The outer diameter of the arterioles might increase up to 2.2-2.3-fold, i.e. in the same range as under twitch contractions. The data showed the similarity in latency values, in the dynamics of arteriole dilation, and the dependency of the latter on the phase of the spontaneous vasomotion preceding the compared stimuli. These findings suggest that arteriolar dilation is determined by mechanically induced inactivation of pace-makers of these vessels both during passive deformations and under twitch contractions.

Animals↗

[The decisive role of the endothelium in stabilizing pressure losses during changes in the blood flow in small arteries].

Previously we established that the pressure drop along arteries remained nearly constant during the many-fold increase of blood flow rate. In anesthetized rats, functional damage of saphenous artery endothelium eliminates this local regulation of its resistance to flow. Hence, it is determined by the sensitivity of the endothelium to the shear stress. The sensitivity threshold has been estimated to be about 50-70 dyn/sm2. This is considerable more than the values characteristic of the cultured endotheliocytes. Possible reasons of this discrepancy under in vivo and in vitro conditions are discussed.

Animals↗

[The effect of the stabilization of a drop in pressure in the arteries during changes in the rate of blood flow].

The saphenous artery was joined with the femoral vein in rats. The pressure drop was measured between the aortic arch and the distal end of the saphenous artery. The stabilization of the pressure losses during the increase of blood flow rate occurs and is determined by dilation mainly of the saphenous artery, the degree of this dilation being such that the pressure drop within the wide range of blood flow rate remain constant.

Animals↗

[Antidromic vasodilation caused by A-delta afferents in the frog].

In anesthetized immobilized frog we recorded changes in hind leg volume evoked by electrical stimulation of peripheral end of the sciatic nerve. The ranges of the stimulus amplitudes sufficient to induce vasodilator or vasoconstrictor reactions were estimated. In a separate set of experiments thresholds of A alpha beta, A delta and C-afferent fibers excitation were evaluated by recording waves of compound action potentials in VIII-X dorsal roots. It was found that vasodilation is elicited by the stimuli of virtually the same intensity range as the excitation of A delta afferent fibers, including low threshold one. Consequently we concluded that in frog these myelinated afferent fibers are capable of dilating the blood vessels by antidromic action. This finding is in contrast with antidromic vasodilation in mammals which is known to result mainly from the impulses of the unmyelinated afferent fibers.

Action Potentials↗

[Decreased thresholds of pain sensation and defense flexor reflex in patients with ischemic heart disease].

It was demonstrated that patients with coronary heart disease with coronary angiographically documented stenosing coronary atherosclerosis and frequent episodes of angina pectoris had significantly higher pain threshold in response to electric skin irritation and greater defense unconditioned flexor reflex R-III threshold than healthy subjects and patients with chest pain of extracoronary genesis.

Adult↗

[Differences in the excitatory action of acetylcholine and mecholine on mechanosensitive high-threshold C-axonal units of the skin in the cat].

Intraarterial acetylcholine (Ach) and acetyl-beta-methylcholine (metacholine, Mch) excite feline high-threshold C-fiber mechanosensitive cutaneous sensory units (SU) in a different way. Ach in noxious (algogenic for humans) concentrations of 10 micrograms/ml and more induces a high-frequency discharge, with mean frequency of impulses at its peak being 4-12 Hz. This discharge seems to result from activation of N-cholinoreceptors because non-noxious and nonalgogenic M-agonist Mch as well as Ach in subnoxious concentrations induce in SU only a low-frequency discharge with a mean frequency of impulses 0.5-3.5 Hz. The data are discussed in connection with nociception and tissue chemoreception.

Acetylcholine↗

[Arteriole reactions of the submaxillary muscle to stationary and periodically repetitive displacements of its fibers and to their contraction].

Stationary local displacement of resting fibers in the frog decentralized submaxillary muscle affected by a piezoelectric device did not usually result in persistent changes of the diameter of nearby arteries. During oscillatory displacement (4 s-1) the same arterioles, exposed to microdeformation of a similar form and amplitude, dilated with a mean diameter increase averaging 36%. During contraction of submaxillary muscle (incomplete tetanus with 4 s-1) the diameter of these vessels increased by 32.69%. Comparison of the data obtained made it possible to suggest that arteriolar myocytes responded with selective relaxation only to the dynamic component of microdeformation.

Animals↗