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Biomedical subjects

V M Klimenko

Publications and source records attributed to V M Klimenko.

At least 19 recordsLinked to original sources
PubMed2001

Effects of serotonin synthesis blockade on interleukin-1 beta action in the brain of rats.

The ability of the brain serotonergic system to mediate the effects of interleukin-1beta (IL-1beta) was investigated. Intracerebroventricular administration of IL-1beta induced a significant pyrogenic reaction, depression in social behaviour, loss of body weight and reduced food intake in rats. Pre-treatment with p-chlorphenylalanine, an inhibitor of serotonin synthesis, blocked the IL-1beta-induced decrease in food intake and loss of body weight, but failed to alter the temperature increase and the decrease in communicative activity.

Animals↗
PubMed2001

Antipyretic effect of neuropeptide galanin in endotoxin-induced fever.

Neuropeptide galanin produces a antipyretic effect in experimental pyrogenic reaction induced by intraperitoneal injection of lipopolysaccharide. Central intracerebroventricular injection of 100 ng galanin significantly attenuated, but did not completely abolish fever. Central galanin injection potentiated endotoxin-induced activation of the noradrenergic system and blocked activation of the serotoninergic system of the anterior hypothalamus.

Animals↗
PubMed2001

[Characteristics of the rat behavior following single and multiple exposures of the hypoglycemic insulin doses].

Rats behaviour in the "open field" changed in 2 hrs after a single episode of hypoglycaemia was abolished with glucose whereas no changes occurred in their stereotyped behaviour and intraspecies interaction. In 24 hrs quantitative parameters of the "open field" behaviour normalised although the behaviour still had an altered structure. At the same time, amphetamine-induced stereotyped behaviour's indices became reduced. These and other findings suggest some deeper behavioural changes in rats during their recovery from repeated hypoglycaemic episodes and absence of synchronisation of the insulin effects.

Aggression↗
PubMed2001

[Interleukin-1beta and depressive states].

Administration of Interleukin-1 beta (IL-1 beta) in pyrogenic and subpyrogenic doses induced a depression of social and exploratory behaviour in rats. A reduction in locomotor activity only occurred with pyrogenic doses of the IL-1 beta. The low dose induced the reduction whereas the high dose the increase of anxiety in elevated plus maze. The opposite effects of two doses of IL-1 beta were observed also in a test with saccharine.

Animals↗
PubMed1996

[Conflict of motivations and the reaction of neutrophilic granulocytes in rats].

A motivational conflict induced a decrease in the cation proteins content in neutrophils within 12 hrs after the stress in make rats. Activity of enzymes taking part in the respiration did not change. A cyclic variation of the cation proteins content was found during the oestrus cycle in neutrophils of female rats.

Animals↗
PubMed1990

[Changes in the level of the permanent potential of the deep brain structures in rabbits with a Brown-Pearce carcinoma].

Rabbits with the Brown-Pierce carcinoma have been studied in chronic experiments for dynamics of the permanent potential reflecting bioelectrochemical processes in different structures of the hypothalamic and limbic system: medial preoptic area, ventromedial nucleus, posterior hypothalamic area, basal and lateral amygdalas, hippocampus, nucleus coeruleus as well as in central nucleus of the suture. The space-temporal pattern of neurodynamic changes in the subcortical brain structures has been found. These changes correlated with developmental characteristics of the Brown-Pierce carcinoma.

Animals↗
PubMed1990

[Efferent neural apparatus of the thymus gland, spleen and lymph nodes and its reaction to electric stimulation of the posterior hypothalamic field].

At a histochemical investigation of the rabbit lymphoid organs innervation certain peculiarities on histotopography of adrenergic and acetylcholinesterase (AChE)-containing nervous elements have been established. At a chronic experiment by means of a dosed repeated bilateral electrostimulation of the posterior hypothalamic field in the organs mentioned, inhibition of the functional activity has been noticed. It is most specific not for the AChE-containing structures, but for the adrenergic ones, localized to some extent in the parenchyma, as well as along the course of the blood vessels and their adventitium. The results are discussed in terms of modulatory influence of the posterior hypothalamic field on trophic and functions of the lymphoid tissue. This influence is realized both humoraly and via the nervous pathways (either directly using certain ways and connections, or indirectly by means of neurogenic tonus of the intraorganic blood vessels regulation).

Acetylcholinesterase↗
PubMed1988

[A model for exploring afferent signals from the immune system to the nervous system].

Mechanisms of information transmission from the immune system to the nervous system have been studied. The results of the studies support the assumption that these signals can be transmitted by oligopeptides (the products of limited proteolysis) which are the fragments found in the active sites of many regulatory peptides of the nervous and immune systems. The testing of a synthesized tripeptide (Ser-Lys-Asp) has shown that it inhibits the antibody-forming cells in intact mice only in response to the administration of large antigen doses and exerts a protective effect against viral infection. When added to the culture of the incubated leukocytes from the peripheral blood of the oncological patients, the tripeptide lowers an increased or normal functional activity of natural killers. In rabbits, tripeptide administration brings about a complex long-lasting reorganization of bioelectrical activity in subcortical structures of the brain.

Animals↗
PubMed1987

[Morphofunctional changes in the adrenergic innervation of the major cerebral arteries during bilateral electrostimulation of the locus coeruleus].

The intramural adrenergic nervous apparatus of cerebral arteries was studied in adult rabbits after 3-10 sessions of electrical stimulation of locus coeruleus. The activity of nerve structures was determined by estimating the density of adrenergic perivascular plexuses and by semi-quantitative cytophotometry of changes in the catecholamine content of nerve varicosities. The stimulation was followed by a 28.2 +/- 1.5% increase in adrenergic innervation density. while catecholamine content in perivascular nerve structures displayed a tendency to decrease. The problem of central effects on cerebral blood flow autoregulation is discussed.

Adrenergic Fibers↗
PubMed1985

[Morphofunctional restructuring of the nervous system of the lymphoid organs during electrostimulation of the hypothalamus].

The intramural nervous apparatus of rabbit lymphoid organs was examined after 15 and 30 sessions of electric stimulation of the posterior hypothalamus. The function of nerve cells was evaluated by cytophotometry according to the content of catecholamines and acetylcholinesterase (ACE) activity. In the mesenteric lymph nodes, stimulation led to a decrease in the activity of both adrenergic and ACE-containing nerve cells. The spleen demonstrated a reduction in the catecholamine content in the perivascular nerve plexuses, with a simultaneous rise of the catecholamine content in the fibers located in the parenchyma, which evidences inhibition of the neurogenous mechanisms of vasomotor control and possible selective activation of the sympathetic mechanisms involved in the regulation of the immunogenesis. Thymic preparations impregnated with silver salts manifested high argyrophilia of the nerve cells, characteristic of the reactive phase of the destructive process. The problems of the hypothalamic effects on the blood supply and functions of the immune system organs are discussed.

Acetylcholinesterase↗
PubMed1984

[Space-time functional organization of the brain subcortical structures in the process of developing immune reactions].

The functional states of subcortical brain structures were investigated with the aid of DC potential and EPs in the course of immune response. Change of the hypothalamic structures' functional state was the same after different antigen immunization during the 1st day of immune process and the latency of this process varied from 9 to 13 min. The inductive and productive periods of primary immune response developed with successive phasic changes in a number of subcortical structures.

Animals↗