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Biomedical subjects

V M Lepeshkov

Publications and source records attributed to V M Lepeshkov.

10 recordsLinked to original sources
PubMed1998

[Gopten (trandolapril) in the treatment of chronic heart failure in patients with ischemic heart disease].

AIM: To investigate clinical efficacy of angiotensin-converting enzyme inhibitor trandolapril and its effects on myocardial function. MATERIALS AND METHOD: 20 patients with ischemic heart disease (IHD) aged 33-74 years with chronic cardiac failure NYHA class II-IV. 4 of them survived myocardial infarction. In addition to the routine tests, the patients underwent echocardiography, radionuclide ventriculography. Trandolapril was given once a day for 28 days in a dose 2 mg, then a repeat examination was performed. RESULTS: Trandolapril produced a subjective effect in 80% of patients. There was also improvement of hemodynamic parameters, an increase in the ejection fraction, sensitivity to nitroglycerin, decline of asynchrony. The drug was well tolerated. CONCLUSION: Trandolapril (Gopten) is effective in IHD patients with chronic cardiac failure.

Adult↗
PubMed1978

[Prognostic possibilities for polyrheography in patients with different variants of the clinical course of myocardial infarct during the acute period].

The paper pertains to a comparative study of the nervous system, cerebral and peripheral circulation in 83 patients with different clinical variants of myocardial infarctions during the first decade of the disease. There were no direct correlations between a decrease in the absolute figures of cerebral pulse repletion and the development of a cerebral stroke. However, the study demonstrated a distinct correlation between the development of cerebral stroke in patients with myocardial infarctions during the first decade and insufficiency of the compensatory intensity of blood repletion both in the cerebral and peripheral vascular basins.

Acute Disease↗
PubMed1976

[Renal filtration function indices and their correction in myocardial infarct].

Glomerular filtration was examined by way of a radioisotope technique using Yb169-labelled ethylenediaminetetracetic acid. The method permits to conduct the examinations without radio-isotope equipment at the bedside of myocardial infarction patients, which is of great practical convenience. The study was conducted in 65 myocardial infarction patients and in 14 control individuals. Glomerular filtration was studied dynamically in different age-groups, in patients with acute and recurrent myocardial infarction with due regard of concomitant hypertension and complications. A correlation of the disorders in glomerular filtration and the age of the patients was revealed. The lowest figures of glomerular filtration were received in patients with myocardial infarction complicated by circulatory insufficiency and, especially, cardiogenic shock. The indices of glomerular filtration correlated with the circulating blood volume and venous pressure not in all patients.

Adult↗